Detailed view for LOAG_07660

Basic information

TDR Targets ID: 941462
Loa Loa (eye worm), STE/STE11/ASK protein kinase
Source Database / ID:  KEGG  

pI: 6.4778 | Length (AA): 975 | MW (Da): 109604 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 149 5ulm (A) 515 655 40.00 0 1 0.473921 -0.39
120 483 3uzs (A) 143 525 24.00 0 1 0.335433 1
164 437 6e2m (B) 671 939 71.00 0 1 1.03723 -0.79
178 631 5iso (A) 21 467 25.00 0 1 0.478541 1.03
873 954 2y9t (A) 546 622 25.00 0 1 0.429003 -1.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130258)

Species Accession Gene Product
Brugia malayi Bm1_16860   Neuronal symmetry protein 1
Drosophila melanogaster Dmel_CG4720   Protein kinase at 92B
Echinococcus granulosus EgrG_000469200   mitogen activated protein kinase kinase kinase
Echinococcus multilocularis EmuJ_000469200   mitogen activated protein kinase kinase kinase
Homo sapiens ENSG00000197442   mitogen-activated protein kinase kinase kinase 5
Homo sapiens ENSG00000180815   mitogen-activated protein kinase kinase kinase 15
Homo sapiens ENSG00000142733   mitogen-activated protein kinase kinase kinase 6
Loa Loa (eye worm) LOAG_07660   STE/STE11/ASK protein kinase
Loa Loa (eye worm) LOAG_10715   hypothetical protein
Loa Loa (eye worm) LOAG_11550   hypothetical protein
Mus musculus ENSMUSG00000031303   mitogen-activated protein kinase kinase kinase 15
Mus musculus ENSMUSG00000028862   mitogen-activated protein kinase kinase kinase 6
Mus musculus ENSMUSG00000071369   mitogen-activated protein kinase kinase kinase 5
Schistosoma japonicum Sjp_0311890   Mitogen-activated protein kinase kinase kinase 15, putative
Schistosoma japonicum Sjp_0098560   IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing
Schistosoma japonicum Sjp_0112540   ko:K04426 mitogen-activated protein kinase kinase kinase 5, putative
Schistosoma japonicum Sjp_0314880   IPR010993,Sterile alpha motif homology,domain-containing
Schistosoma japonicum Sjp_0069170   Mitogen-activated protein kinase kinase kinase 15, putative
Schistosoma japonicum Sjp_0112550   expressed protein
Schistosoma japonicum Sjp_0133840   IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing
Schistosoma mansoni Smp_162800.2   protein kinase
Schistosoma mansoni Smp_162800.1   protein kinase
Schmidtea mediterranea mk4.002610.03  
Schmidtea mediterranea mk4.010145.00  
Schmidtea mediterranea mk4.006075.05  
Schmidtea mediterranea mk4.001906.00  
Schmidtea mediterranea mk4.005023.02  
Schmidtea mediterranea mk4.011946.00  
Schmidtea mediterranea mk4.015163.00   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.005023.04   Mitogen-activated protein kinase kinase kinase 6
Schmidtea mediterranea mk4.000175.10  
Trypanosoma cruzi TcCLB.509937.130   STE/STE11 serine/threonine-protein kinase, putative
Trypanosoma cruzi TcCLB.510409.10   STE/STE11 serine/threonine-protein kinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mitogen-activated protein kinase kinase kinase 6 Compounds References
Homo sapiens mitogen-activated protein kinase kinase kinase 5 Compounds References
Homo sapiens mitogen-activated protein kinase kinase kinase 15 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 29.4% 289 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 27.4% 292 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 23.2% 271 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 36.3% 157 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0709 0.2992 0.2998
0.0137 0.2648 0.2652
0.0088 0.4477 0.4477
0.1005 0.3011 0.3015
0.0852 0.3002 0.3004
0.0557 0.2971 0.2975
0.0026 0.5 0.5
0.0144 0.2731 0.2617
0.0448 0.2965 0.2955
0.0091 1 1
0.0529 0.2986 0.2949
0.1109 0.2999 0.3002
0.0067 0.5 0.5
0.0313 0.2949 0.2912
0.1117 0.3011 0.3016
0.0126 0.2567 0.2587
0.0464 0.2991 0.2995
0.1166 0.3011 0.3016
0.0982 0.3013 0.3015
0.0033 1 1
0.0672 0.3007 0.3012
0.1147 0.3013 0.3016
0.0963 0.3 0.3005
0.0029 0.5 0.5
0.0016 0.5 0.5
0.1054 0.3006 0.3011
0.0539 0.2978 0.2982
0.0074 0.2851 0.2856
0.0397 0.2986 0.2991
0.0557 0.2586 0.2987
0.0703 0.2997 0.3001
0.1035 0.3 0.3004
0.0191 0.2901 0.2905
0.0032 0.5 0.5
0.1105 0.3016 0.302
0.0063 1 1
0.049 0.2989 0.2992
0.0749 0.2988 0.2992
0.0607 0.2608 0.2982
0.0023 0.5 0.5
0.0557 0.2586 0.2987
0.0373 0.2978 0.2977
0.1172 0.3002 0.3003
0.0648 0.3006 0.3007
0.0952 0.3016 0.302
0.0641 0.2988 0.2992
0.0081 0.5 0.5
0.0861 0.2923 0.2923
0.0861 0.2923 0.2923
0.0557 0.2971 0.2975
0.0634 0.2992 0.2966
0.0327 0.2901 0.2914
0.0756 0.299 0.2994
0.1054 0.3 0.3003
0.097 0.3005 0.3009
0.08 0.2998 0.3002
0.0851 0.3009 0.3014
0.1292 0.3013 0.3018
0.0322 0.2863 0.2867
0.0003 0.5 0.5
0.0333 0.2903 0.2908
0.0037 1 0.5
0.0734 0.2991 0.2995
0.0004 0.5 0.5
0.0039 0.5 0.5
0.0313 0.3002 0.3003
0.0248 0.2994 0.2998
0.0191 0.2901 0.2905
0.1152 0.2717 0.2722
0.1126 0.3012 0.3015
0.0249 0.2752 0.2999
0.0442 0.3006 0.3011
0.1152 0.2717 0.2722
0.0497 0.2973 0.297
0.0956 0.3 0.3005
0.1184 0.3006 0.3011
0.0736 0.2996 0.3
0.0765 0.2975 0.2983
0.0011 1 1
0.0093 0.8828 0.8828
0.0554 0.2977 0.2977
0.0032 0.5 0.5
0.0251 0.3009 0.3014
0.0463 0.2871 0.2861
0.0186 0.2629 0.2952
0.0673 0.2985 0.2986
0.1152 0.2717 0.2722
0.0404 0.3004 0.3008
0.0782 0.2963 0.2967
0.0142 0.2784 0.2788
0.1189 0.2982 0.3015
0.0976 0.2995 0.2999
0.0316 0.2993 0.2958
0.0251 0.292 0.2924
0.0433 0.3006 0.3002
0.1159 0.3014 0.3017
0.1227 0.3016 0.302
0.089 0.2981 0.2985
0.1251 0.3001 0.3006
0.1447 0.3004 0.3008
0.0317 0.297 0.2974
0.0324 0.2969 0.2975
0.123 0.3014 0.3018
0.0081 1 1
0.0349 0.2675 0.2679
0.0464 0.2991 0.2995
0.0557 0.2586 0.2987
0.1044 0.2997 0.2998
0.1234 0.3008 0.3013
0.0016 0.5 0.5
0.0139 0.2961 0.2948
0.0007 0.5 0.5
0.1027 0.3002 0.3005
0.0412 0.2986 0.299
0.0489 0.298 0.2985
0.0591 0.2984 0.2989
0.0022 0.5 0.5
0.0059 1 1
0.0896 0.3003 0.299
0.059 0.2971 0.2976
0.0059 1 1
0.0126 0.2835 0.281
0.0144 0.2731 0.2617
0.0864 0.3011 0.3015
0.0353 0.294 0.2953
0.1345 0.3011 0.3011
0.0845 0.2993 0.299
0.0208754 0.251951 0.256421
0.0809 0.3006 0.301
0.0579 0.2966 0.2967
0.1455 0.3006 0.3011
0.0656 0.2992 0.2996
0.0629 0.297 0.2971
0.0981 0.301 0.3011
0.111 0.2998 0.3001
0.1167 0.3016 0.302
0.0062 0.6935 0.6935
0.0679 0.2985 0.2987
0.0682 0.3004 0.3008
0.0354 0.2949 0.2954
0.0007 0.5 0.5
0.0042 0.5 0.5
0.1041 0.3012 0.3013
0.1311 0.3015 0.302
0.0911 0.2992 0.2994
0.0312 0.2999 0.3003
0.0033 0.5 0.5
0.0743 0.3005 0.301
0.1175 0.2999 0.3003
0.0882 0.2993 0.2997
0.0623 0.2981 0.2984
0.0433 0.3009 0.3013
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0554 0.2977 0.2977
0.0059 1 1
0.1234 0.3008 0.3013
0.0018 0.5 0.5
0.0334444 0.263004 0.269002
0.0619 0.2869 0.2986
0.0862 0.3 0.3004
0.0433 0.3006 0.3002
0.0845 0.2993 0.299
0.0066 0.3101 0.3068
0.0577 0.2966 0.2967
0.0063 0.7244 0.6686
0.0682 0.3004 0.3008
0.0012 0.5 0.5
0.0844 0.3001 0.3006
0.0075 0.2617 0.2631
0.0855 0.2996 0.2998
0.0316 0.2993 0.2958
0.0056 1 1
0.039 0.2993 0.2998
0.0039 0.5 0.5
0.0633 0.2993 0.299
0.0539 0.2978 0.2982
0.0319 0.2965 0.2969
0.1309 0.3015 0.3018
0.0244 0.2901 0.3
0.0315 0.2967 0.2971
0.0956 0.3 0.3005
0.0311 0.3002 0.3007
0.0061 0.6883 0.6883
0.1308 0.3013 0.3017
0.1044 0.3001 0.3006
0.0385 0.283 0.2827
0.0377 0.2934 0.2924
0.0254 0.301 0.3014
0.125 0.3016 0.3019
0.0069 0.3067 0.9179
0.061 0.3011 0.3016
0.0064 0.3377 0.3377
0.0574 0.2957 0.2961
0.047 0.2995 0.3
0.0039 0.9485 1
0.0126 0.2567 0.2587
0.0744 0.3009 0.3013
0.0832 0.3015 0.3019
0.0446 0.3007 0.3012
0.047 0.2923 0.2927
0.0371 0.2682 0.2973
0.1158 0.3009 0.3014
0.0378 0.2996 0.3
0.0749 0.2988 0.2992
0.1408 0.2998 0.3003
0.0036 0.5 0.5
0.0012 0.5 0.5
0.0965 0.2996 0.2994
0.1421 0.3008 0.3008
0.0577 0.2997 0.3002
0.0577 0.2997 0.3002
0.0098 0.3242 0.3017
0.0601 0.2878 0.2883
0.0861 0.2923 0.2923
0.0008 0.5 0.5
0.0062 0.2614 0.263
0.1374 0.3014 0.3018
0.0186 0.2629 0.2952
0.1142 0.2989 0.2986
0.0363 0.3004 0.2997
0.0434 0.2525 0.298
0.0956 0.3 0.3005
0.0749 0.2988 0.2992
0.0092 1 1
0.1235 0.2997 0.3002
0.0433 0.3009 0.3013
0.1123 0.2997 0.3001
0.0697 0.2996 0.2999
0.0925 0.3012 0.3016
0.0675 0.3009 0.3013
0.0603 0.3002 0.3006
0.1152 0.2717 0.2722
0.1214 0.3006 0.3004
0.0394273 0.256777 0.263296
0.0027 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_07660 (Loa Loa (eye worm)), STE/STE11/ASK protein kinase
Title for this comment
Comment