Detailed view for LOAG_09860

Basic information

TDR Targets ID: 941742
Loa Loa (eye worm), STE/STE7/MEK7 protein kinase
Source Database / ID:  KEGG  

pI: 8.5896 | Length (AA): 394 | MW (Da): 44649 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
25 368 5mo4 (A) 171 510 23.00 0 1 1.0226 0.58
99 394 5y90 (A) 119 418 54.00 0 1 1.40677 -1.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133887)

Species Accession Gene Product
Brugia malayi Bm1_27865   Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED-
Caenorhabditis elegans CELE_K08A8.1   Protein MEK-1, isoform B
Drosophila melanogaster Dmel_CG4353   hemipterous
Echinococcus granulosus EgrG_000123600   dual specificity mitogen activated protein
Echinococcus multilocularis EmuJ_000123600   dual specificity mitogen activated protein
Homo sapiens ENSG00000076984   mitogen-activated protein kinase kinase 7
Loa Loa (eye worm) LOAG_04083   STE/STE7/MEK7 protein kinase
Loa Loa (eye worm) LOAG_09860   STE/STE7/MEK7 protein kinase
Mus musculus ENSMUSG00000002948   mitogen-activated protein kinase kinase 7
Schistosoma japonicum Sjp_0092850   IPR011009,Protein kinase-like,domain-containing
Schistosoma japonicum Sjp_0217640   ko:K04431 mitogen-activated protein kinase kinase 7, putative
Schistosoma japonicum Sjp_0311500   Dual specificity mitogen-activated protein kinase kinase 7, putative
Schistosoma mansoni Smp_031940   protein kinase
Schmidtea mediterranea mk4.000038.01   Dual specificity mitogen-activated protein kinase kinase 7

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mitogen-activated protein kinase kinase 7 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.2% 286 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 25.4% 284 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.6% 286 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.9% 286 aa Compounds References
Bos taurus Casein kinase I isoform alpha 325 aa 26.3% 278 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.8298 1 1
0.5046 1 1
0.4028 1 1
0.0641 0.652 0.9895
0.0281 1 1
0.4028 1 1
0.7875 1 1
0.4028 1 1
0.7681 1 1
0.6707 1 1
0.4967 1 1
0.3516 0.6339 0.704
0.7401 1 1
0.0362 0.8734 0.8734
0.6707 1 1
0.3332 1 1
0.7875 1 1
0.1562 0.9784 1
0.239 1 1
0.0036 0.5 0.5
0.0149 0.5 0.5
0.4097 0.8261 1
0.4028 1 1
0.0092 1 1
0.4026 1 1
0.7085 1 1
0.0258 0.3035 0.5512
0.6707 1 1
0.4941 1 1
0.0007 0.5 0.5
0.0088 0.4477 0.4477
0.0004 0.5 0.5
0.0059 1 1
0.0251 0.2934 0.5328
0.0003 0.5 0.5
0.0011 1 1
0.6707 1 1
0.5114 1 1
0.6907 1 1
0.0242 0.5 0.5
0.7545 1 1
0.5963 1 1
0.2453 1 1
0.6211 1 1
0.4137 1 1
0.0149 0.5 0.5
0.1135 1 0.5
0.3232 0.9784 1
0.0255 0.5 0.5
0.0391 0.2649 1
0.1361 1 1
0.4155 1 1
0.2955 1 1
0.7794 1 1
0.0081 1 1
0.1403 1 0.5
0.3964 1 1
0.0066 0.3101 0.3068
0.5058 1 1
0.3079 1 1
0.3595 1 1
0.0126 0.8153 0.8153
0.7578 1 1
0.0765 1 0.5
0.2955 1 1
0.6875 1 1
0.6707 1 1
0.0149 0.5 0.5
0.1128 1 1
0.6118 0.5 0.5
0.4568 1 1
0.8255 1 1
0.3398 1 1
0.0029 0.5 0.5
0.7875 1 1
0.0149 0.5 0.5
0.0505 0.6205 1
0.327 1 1
0.0149 0.5 0.5
0.1237 1 1
0.0149 0.5 0.5
0.1562 0.9784 1
0.3416 1 1
0.0149 0.5 0.5
0.0007 0.5 0.5
0.5241 1 1
0.5457 1 1
0.0833 1 0.5
0.3836 1 1
0.3163 1 1
0.3167 1 1
0.0267 1 1
0.0012 0.5 0.5
0.1631 0.4174 0.4172
0.1631 0.4174 0.4172
0.0042 0.5 0.5
0.6707 1 1
0.7645 1 1
0.0369 1 1
0.0149 0.5 0.5
0.012 0.804 0.795
0.361 1 1
0.0256 0.8115 0.8115
0.6735 1 1
0.5375 1 1
0.4175 1 1
0.6707 1 1
0.1562 0.9784 1
0.1872 1 1
0.2138 1 1
0.0016 0.5 0.5
0.0039 0.9485 1
0.1872 1 1
0.0059 1 1
0.6337 1 1
0.4028 1 1
0.4061 0.5368 0.5363
0.0121 1 1
0.0062 0.6935 0.6935
0.6707 1 1
0.7253 1 1
0.1628 1 1
0.0016 0.5 0.5
0.1631 0.4174 0.4172
0.4044 1 1
0.0056 1 1
0.0027 1 1
0.0393 1 1
0.1361 1 1
0.0081 0.5 0.5
0.0007 0.5 0.5
0.8446 1 1
0.4028 1 1
0.1562 0.9784 1
0.0069 0.3067 0.9179
0.1135 1 0.5
0.0033 0.5 0.5
0.1497 1 1
0.0391 0.2649 1
0.8027 1 1
0.3595 1 1
0.4967 1 1
0.0149 0.5 0.5
0.0098 0.3242 0.3017
0.04 1 1
0.0018 0.5 0.5
0.2643 1 1
0.0033 1 1
0.012 0.9518 0.9565
0.0149 0.5 0.5
0.0121 1 1
0.4028 1 1
0.6707 1 1
0.2417 1 1
0.3562 1 1
0.4016 1 1
0.7169 1 1
0.0149 0.5 0.5
0.4967 1 1
0.1943 1 1
0.0012 0.5 0.5
0.4967 1 1
0.3516 0.6339 0.704
0.2794 1 1
0.3347 1 1
0.6707 1 1
0.4028 1 1
0.1765 1 1
0.7808 1 1
0.1497 1 1
0.4097 0.8261 1
0.0039 0.5 0.5
0.2666 1 1
0.0064 0.3377 0.3377
0.0063 0.7244 0.6686
0.0067 0.5 0.5
0.2442 1 1
0.7875 1 1
0.5971 1 1
0.3161 1 1
0.0511 1 1
0.0023 0.5 0.5
0.0391 0.2649 1
0.3329 1 1
0.4028 1 1
0.6707 1 1
0.0422 0.4949 0.9504
0.3806 1 1
0.0091 1 1
0.0121 1 1
0.5629 1 1
0.7098 1 1
0.6707 1 1
0.6604 1 1
0.1631 0.4174 0.4172
0.8444 1 1
0.0149 0.5 0.5
0.3585 1 1
0.4028 1 1
0.4028 1 1
0.1396 1 1
0.361 1 1
0.5457 1 1
0.6707 1 1
0.0022 0.5 0.5
0.0149 0.5 0.5
0.1562 0.9784 1
0.6736 1 1
0.303 1 1
0.6012 0.5 0.5
0.4967 1 1
0.6707 1 1
0.858 1 1
0.0267 1 1
0.8055 1 1
0.361 1 1
0.4157 1 1
0.8446 1 1
0.1396 1 1
0.2925 1 1
0.7955 1 1
0.0641 0.652 0.9895
0.6336 1 1
0.012 0.8135 0.8135
0.2736 1 1
0.8484 1 1
0.3332 1 1
0.1631 0.4174 0.4172
0.2736 1 1
0.0391 0.2649 1
0.4028 1 1
0.2509 0.6716 1
0.6707 1 1
0.0039 0.5 0.5
0.5932 1 1
0.2784 1 1
0.3163 1 1
0.0241 0.5 0.5
0.4028 1 1
0.0026 0.5 0.5
0.0258 0.3035 0.5512
0.361 1 1
0.8298 1 1
0.303 1 1
0.8446 1 1
0.0063 1 1
0.0059 1 1
0.3753 1 1
0.4137 1 1
0.1562 0.9784 1
0.0037 1 0.5
0.8484 1 1
0.0149 0.5 0.5
0.6707 1 1
0.3516 0.6339 0.704
0.5827 1 1
0.4028 1 1
0.6707 1 1
0.8446 1 1
0.4028 1 1
0.5925 1 1
0.2212 1 1
0.0119 1 1
0.3753 1 1
0.0008 0.5 0.5
0.0093 0.8828 0.8828
0.0061 0.6883 0.6883
0.6707 1 1
0.1631 0.4174 0.4172
0.6604 1 1
0.2831 0.2711 0.934
0.0032 0.5 0.5
0.0833 0.332 1
0.3163 1 1
0.0149 0.5 0.5
0.3666 1 1
0.0375 1 1
0.0149 0.5 0.5
0.4674 1 1
0.4014 1 1
0.5997 1 1
0.3232 0.9784 1
0.1562 0.9784 1
0.4061 0.5368 0.5363
0.1128 1 1
0.1751 1 1
0.7107 1 1
0.0032 0.5 0.5
0.0149 0.5 0.5
0.0149 0.5 0.5
0.0012 0.5 0.5
0.4025 1 1
0.6707 1 1
0.0398 1 1
0.361 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_09860 (Loa Loa (eye worm)), STE/STE7/MEK7 protein kinase
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