Detailed view for LOAG_03140

Basic information

TDR Targets ID: 941823
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 7.8778 | Length (AA): 744 | MW (Da): 83329 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00483   Nucleotidyl transferase
PF02544   3-oxo-5-alpha-steroid 4-dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016627   oxidoreductase activity, acting on the CH-CH group of donors  
GO:0016021   integral to membrane  
GO:0005737   cytoplasm  
GO:0016779   nucleotidyltransferase activity  
GO:0005515   protein binding  
GO:0009058   biosynthetic process  
GO:0006629   lipid metabolic process  

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 82 2dzj (A) 8 88 31.00 0 1 0.491615 -0.15
11 80 2klc (A) 30 96 22.00 0.34 1 0.399486 -0.69
23 83 3dbh (I) 116 175 32.00 0 1 0.386289 0.19
24 84 2dzm (A) 25 85 26.00 0.99 0.77 0.318389 0.27
312 717 5b04 (I) 17 407 21.00 0.000000041 1 0.635799 0.65
314 346 3dk5 (A) 8 37 40.00 0 0.03 0.129655 2.07
616 734 3vnp (A) 3 131 15.00 0.21 0.57 0.346346 -0.73
664 701 1fxj (A) 290 327 21.00 0 0.81 0.337375 -0.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128844)

Species Accession Gene Product
Arabidopsis thaliana AT5G19485   transferases/nucleotidyltransferases
Babesia bovis BBOV_II000340   hypothetical protein
Brugia malayi Bm1_42560   Nucleotidyl transferase family protein
Candida albicans CaO19.481   similar to S. cerevisiae GCD1 (YOR260W) gamma subunit of eIF-2B, the guanine nucleotide exchange factor for translation initiati
Candida albicans CaO19.8111   similar to S. cerevisiae GCD1 (YOR260W) gamma subunit of eIF-2B, the guanine nucleotide exchange factor for translation initiati
Caenorhabditis elegans CELE_C15F1.4   Protein PPP-1
Caenorhabditis elegans CELE_C15F1.3   Protein TRA-2, isoform C
Cryptosporidium hominis Chro.80452   hypothetical protein
Cryptosporidium parvum cgd8_3940   eIF-2B gamma, eukaryotic translation initiation factor 2B subunit 3 that has a nucleotide diphospho sugar transferase at the N-t
Dictyostelium discoideum DDB_G0290693   bacterial transferase hexapeptide repeat-containing protein
Drosophila melanogaster Dmel_CG8190   CG8190 gene product from transcript CG8190-RA
Echinococcus granulosus EgrG_000671300   DNA polymerase epsilon catalytic subunit
Echinococcus multilocularis EmuJ_000671300   DNA polymerase epsilon catalytic subunit
Homo sapiens ENSG00000070785   eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
Loa Loa (eye worm) LOAG_03140   hypothetical protein
Mus musculus ENSMUSG00000028683   eukaryotic translation initiation factor 2B, subunit 3
Neospora caninum NCLIV_059920   eukaryotic initiation factor-2B gamma subunit, putative
Oryza sativa 4340947   Os06g0338900
Onchocerca volvulus OVOC4928  
Plasmodium berghei PBANKA_1341600   translation initiation factor eIF-2B subunit gamma, putative
Plasmodium falciparum PF3D7_1326400   translation initiation factor eIF-2B subunit gamma, putative
Plasmodium knowlesi PKNH_1202200   translation initiation factor eIF-2B subunit gamma, putative
Plasmodium vivax PVX_116557   translation initiation factor EIF-2B gamma subunit, putative
Plasmodium yoelii PY05721   hypothetical protein
Plasmodium yoelii PY05722   hypothetical protein
Saccharomyces cerevisiae YOR260W   Gcd1p
Schistosoma japonicum Sjp_0213650   ko:K03241 translation initiation factor eIF-2B gamma subunit, putative
Toxoplasma gondii TGME49_216260   eukaryotic initiation factor-2B, gamma subunit, putative
Theileria parva TP01_0593   hypothetical protein, conserved

Essentiality

LOAG_03140 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C15F1.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_C15F1.4 Caenorhabditis elegans larval arrest wormbase
CELE_C15F1.4 Caenorhabditis elegans larval lethal wormbase
CELE_C15F1.4 Caenorhabditis elegans slow growth wormbase
CELE_C15F1.4 Caenorhabditis elegans sterile wormbase
YOR260W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1341600 Plasmodium berghei Essential plasmo
TGME49_216260 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.008 0.3061 0.3061
0.1591 0.424 0.424
0.0044 0.2692 0.2692
0.1687 0.5672 0.5672
0.0113 0.2725 0.4356
0.3311 0.2651 0.2651
0.1682 0.5565 0.5565
0.0098 1 1
0.0496 0.3494 0.3494
0.0093 0.5 0.5
0.0933 0.3572 0.5158
0.1629 0.5572 0.5572
0.4138 0.2589 0.2589
0.0042 1 1
0.4259 0.2536 0.2536
0.1571 0.5874 0.5871
0.0291 0.3261 0.3796
0.0989 0.3014 0.3014
0.1243 0.5928 0.5928
0.1629 0.5572 0.5572
0.0305 0.3463 0.3915
0.1581 0.5481 0.5121
0.1554 0.3544 0.398
0.0211 0.5639 0.5639
0.0042 0.3015 0.3768
0.0155 1 1
0.0053 1 1
0.0307 0.4445 0.4445
0.0043 0.5 0.5
0.0338 0.3879 0.518
0.079 0.4926 0.4926
0.049 0.2727 0.3285
0.0652 0.5389 0.5389
0.0411 0.5047 0.5907
0.0555 0.3152 0.3234
0.02 0.2564 0.3535
0.0052 0.4576 0.6448
0.0359 0.3037 0.3037
0.0044 1 1
0.0137 0.2726 0.9213
0.008 0.3061 0.3061
0.0211 0.5639 0.5639
0.0283 0.3836 0.3836
0.0088 0.2846 0.2846
0.051 0.578 0.578
0.0299 0.3146 0.3146
0.0301 0.5 0.5
0.0099 1 1
0.0996 0.3364 0.3812
0.0279 0.4126 0.4126
0.0053 0.5 0.5
0.022 1 1
0.0132 0.4213 0.4842
0.0996 0.3364 0.3812
0.0088 0.2846 0.2846
0.049 0.2727 0.3285
0.0184 0.2514 1
0.0044 0.5 0.5
0.0342 0.5715 0.5715
0.0201 0.4631 1
0.0255 0.3177 0.3732
0.0192 0.2683 1
0.4035 0.2725 0.2723
0.015 0.4363 0.2201
0.0304 0.4297 0.4297
0.0194 1 1
0.0044 1 1
0.1554 0.3544 0.398
0.0066 0.3029 0.3029
0.0044 1 1
0.0269 0.4728 0.4728
0.0933 0.3572 0.5158
0.1654 0.4908 0.4908
0.0309 0.5 0.5
0.0404 0.4171 0.4516
0.005 0.5523 0.5523
0.0043 1 1
0.0513 0.7658 0.7658
0.0051 1 1
0.0151 0.5 0.5
0.4138 0.2589 0.2589
0.4318 0.2522 0.2522
0.0051 1 1
0.0043 1 1
0.0394 0.681 0.681
0.0307 0.2535 0.2533
0.0538 0.5231 0.5231
0.3121 0.2582 0.2579
0.1554 0.3544 0.398
0.0053 0.3812 1
0.0309 0.5 0.5
0.0338 0.3879 0.518
0.0102 1 1
0.009 0.297 0.276
0.0401 0.2707 0.2707
0.0048 0.7671 0.7671
0.008 0.3061 0.3061
0.0097 1 1
0.0668 0.2557 0.4004
0.0295 0.5 0.5
0.0042 1 1
0.0386 0.5441 0.6256
0.0044 0.5714 0.5714
0.4138 0.2589 0.2589
0.0051 1 1
0.0097 1 1
0.0359 0.3037 0.3037
0.0229 0.5 0.5
0.4138 0.2589 0.2589
0.0195 0.2748 0.6343
0.01 1 1
0.0499 0.2718 0.3604
0.071 0.3797 0.3797
0.0126 0.4331 0.4264
0.0045 1 1
0.0259 0.3916 0.3916
0.0113 0.4246 0.4246
0.0207 1 1
0.1554 0.3544 0.398
0.1629 0.5572 0.5572
0.03 0.2511 0.2509
0.0555 0.3152 0.3234
0.0223 0.4122 0.4122
0.0253 0.3363 0.3819
0.1571 0.5874 0.5871
0.0433 0.612 1
0.0143 0.5042 0.4146
0.1554 0.3544 0.398
0.0105 1 1
0.0658 0.3619 0.3619
0.0135 0.3062 0.3604
0.0043 1 1
0.032 0.2562 0.2562
0.0045 0.2685 0.2685
0.0266 0.3291 0.3291
0.023 0.2518 0.3926
0.4318 0.252 0.2519
0.0404 0.4171 0.4516
0.1682 0.5565 0.5565
0.1096 0.5261 0.5261
0.1554 0.3544 0.398
0.0355 0.5 0.5
0.1687 0.5672 0.5672
0.0101 1 1
0.0444 0.6168 0.6168
0.0135 0.2869 0.2869
0.062 0.2871 0.4445
0.0043 1 1
0.1711 0.5682 0.5682
0.005 1 1
0.0366 0.3132 0.3095
0.0496 0.3368 0.3368
0.0256 0.4166 0.4163
0.1554 0.3544 0.398
0.1622 0.5875 0.5798
0.1476 0.6522 0.6522
0.0043 1 1
0.4138 0.2589 0.2589
0.0433 0.612 1
0.0213 0.6298 0.6298
0.009 0.3115 0.3115
0.1682 0.5565 0.5565
0.0378 0.4707 0.4766
0.0444 1 1
0.0044 1 1
0.1682 0.5565 0.5565
0.0309 0.5 0.5
0.0051 1 1
0.3121 0.2582 0.2579
0.0933 0.3572 0.5158
0.0053 0.5 0.5
0.0488 0.2858 0.3275
0.0053 1 1
0.1096 0.5261 0.5261
0.0119 0.3398 0.3033
0.0366 0.456 0.5582
0.0104 1 1
0.0066 0.3029 0.3029
0.005 0.257 0.257
0.1516 0.286 0.6185
0.4035 0.2725 0.2723
0.2295 0.6163 0.6163
0.1554 0.3544 0.398
0.0342 0.2831 0.2851
0.2756 0.2602 0.2602
0.0076 0.3029 0.3029
0.0308 0.6156 0.6156
0.0051 0.8747 1
0.1058 0.3216 0.3962
0.0195 0.5927 0.5927
0.1554 0.3544 0.398
0.0044 1 1
0.0043 1 1
0.0153 1 1
0.0051 1 1
0.0044 1 1
0.0043 0.3597 0.3597
0.0844 0.5869 0.5863
0.0159 0.266 0.266
0.1711 0.5682 0.5682
0.1703 0.5236 0.5236
0.005 0.5344 0.58
0.0129 0.289 0.289
0.0198 1 1
0.35 0.2629 0.2629
0.1581 0.5481 0.5121
0.0126 0.4083 0.4083
0.0047 1 1
0.0043 1 1
0.1554 0.3544 0.398
0.0392 0.322 0.322
0.0122 0.3443 0.3535
0.1046 0.4051 0.4045
0.0844 0.5869 0.5863
0.1687 0.5672 0.5672
0.0201 1 1
0.1483 0.6596 0.6596
0.0538 0.5231 0.5231
0.0255 0.3177 0.3732
0.0304 0.4297 0.4297
0.0066 0.301 0.3003
0.0307 0.2535 0.2533

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LOAG_03140 (Loa Loa (eye worm)), hypothetical protein
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