Detailed view for LOAG_16084

Basic information

TDR Targets ID: 941824
Loa Loa (eye worm), voltage-gated potassium channel
Source Database / ID:  KEGG  

pI: 5.215 | Length (AA): 118 | MW (Da): 14032 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0008076   voltage-gated potassium channel complex  
GO:0005249   voltage-gated potassium channel activity  
GO:0006813   potassium ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 38 1nn7 (A) 111 146 47.00 0.026 0.16 0.779485 -0.11
26 62 6dkm (B) 108 146 32.00 0.32 0.13 0.761959 -1.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129881)

Species Accession Gene Product
Brugia malayi Bm1_12070   Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog
Caenorhabditis elegans CELE_Y73B6BL.19   Protein SHL-1
Drosophila melanogaster Dmel_CG9262   Shaker cognate l
Echinococcus granulosus EgrG_000215300   potassium voltage gated channel protein
Echinococcus granulosus EgrG_000749100   potassium voltage gated channel protein
Echinococcus granulosus EgrG_000215200   potassium voltage gated channel subfamily D
Echinococcus granulosus EgrG_000204600   potassium voltage gated channel subfamily D
Echinococcus multilocularis EmuJ_000215300   conserved hypothetical protein
Echinococcus multilocularis EmuJ_000204600   potassium voltage gated channel subfamily D
Echinococcus multilocularis EmuJ_000749100   potassium voltage gated channel protein
Echinococcus multilocularis EmuJ_000215200   potassium voltage gated channel subfamily D
Homo sapiens ENSG00000102057   potassium voltage-gated channel, Shal-related subfamily, member 1
Homo sapiens ENSG00000171385   potassium voltage-gated channel, Shal-related subfamily, member 3
Homo sapiens ENSG00000184408   potassium voltage-gated channel, Shal-related subfamily, member 2
Loa Loa (eye worm) LOAG_16084   voltage-gated potassium channel
Loa Loa (eye worm) LOAG_15890   hypothetical protein
Loa Loa (eye worm) LOAG_15575   hypothetical protein
Loa Loa (eye worm) LOAG_16219   Kv4.2 voltage-gated potassium channel
Mus musculus ENSMUSG00000040896   potassium voltage-gated channel, Shal-related family, member 3
Mus musculus 16506   potassium voltage-gated channel, Shal-related family, member 1
Mus musculus ENSMUSG00000060882   potassium voltage-gated channel, Shal-related family, member 2
Schistosoma japonicum Sjp_0062830   Potassium voltage-gated channel protein Shal, putative
Schistosoma japonicum Sjp_0062840   IPR000194,ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding,domain-containing
Schistosoma japonicum Sjp_0020130   Potassium voltage-gated channel subfamily D member 1, putative
Schistosoma japonicum Sjp_0016850   ko:K04893 potassium voltage-gated channel, Shal-related subfamily D, member 3, putative
Schistosoma japonicum Sjp_0078180   Potassium voltage-gated channel protein Shal, putative
Schistosoma mansoni Smp_035160   voltage-gated potassium channel
Schistosoma mansoni Smp_160780   voltage-gated potassium channel
Schmidtea mediterranea mk4.005552.01   Potassium voltage-gated channel protein Shal
Schmidtea mediterranea mk4.022420.02   Potassium voltage-gated channel protein Shal
Schmidtea mediterranea mk4.024086.00   Potassium voltage-gated channel protein Shal
Schmidtea mediterranea mk4.009448.00   Potassium voltage-gated channel protein Shal
Schmidtea mediterranea mk4.028713.00   Potassium voltage-gated channel protein Shal
Schmidtea mediterranea mk4.015555.02   Potassium voltage-gated channel protein Shal

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Potassium voltage-gated channel subfamily D member 2 Compounds References
Homo sapiens potassium voltage-gated channel, Shal-related subfamily, member 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_16084 (Loa Loa (eye worm)), voltage-gated potassium channel
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