Detailed view for LOAG_06546

Basic information

TDR Targets ID: 941933
Loa Loa (eye worm), Sodium:neurotransmitter symporter family protein

Source Database / ID:  KEGG  

pI: 5.9085 | Length (AA): 701 | MW (Da): 78961 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00209   Sodium:neurotransmitter symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005328   neurotransmitter:sodium symporter activity  
GO:0006836   neurotransmitter transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
71 423 5i6x (A) 75 439 38.00 0 1 0.960466 -0.24
71 667 5i6x (A) 75 617 35.00 0 1 1.15164 -0.09
73 667 4xp4 (A) 25 599 37.00 0 1 1.19379 -0.24
75 645 2a65 (A) 5 508 22.00 0 0.99 0.958451 -0.18
75 555 2a65 (A) 5 489 17.00 0.0000044 0.29 0.928163 -0.72
75 596 4us3 (A) 9 447 23.00 0 1 0.87355 -0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128287)

Species Accession Gene Product
Brugia malayi Bm1_34985   Sodium:neurotransmitter symporter family protein
Drosophila melanogaster Dmel_CG43066   CG43066 gene product from transcript CG43066-RC
Drosophila melanogaster Dmel_CG10804   CG10804 gene product from transcript CG10804-RD
Homo sapiens ENSG00000174358   solute carrier family 6 (neutral amino acid transporter), member 19
Homo sapiens ENSG00000163817   solute carrier family 6 (proline IMINO transporter), member 20
Homo sapiens ENSG00000197106   solute carrier family 6 (neutral amino acid transporter), member 17
Homo sapiens ENSG00000164363   solute carrier family 6 (neutral amino acid transporter), member 18
Homo sapiens ENSG00000072041   solute carrier family 6 (neutral amino acid transporter), member 15
Loa Loa (eye worm) LOAG_06546   Sodium:neurotransmitter symporter family protein
Mus musculus ENSMUSG00000025243   solute carrier family 6 (neurotransmitter transporter), member 20B
Mus musculus ENSMUSG00000021612   solute carrier family 6 (neurotransmitter transporter), member 18
Mus musculus 74338   solute carrier family 6 (neurotransmitter transporter), member 19
Mus musculus ENSMUSG00000019894   solute carrier family 6 (neurotransmitter transporter), member 15
Mus musculus ENSMUSG00000036814   solute carrier family 6 (neurotransmitter transporter), member 20A
Mus musculus ENSMUSG00000027894   solute carrier family 6 (neurotransmitter transporter), member 17

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 6 (neutral amino acid transporter), member 15 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaca mulatta Transporter 620 aa 31.9% 592 aa Compounds References
Rattus norvegicus Glycine transporter 1 638 aa 32.2% 622 aa Compounds References
Rattus norvegicus GABA transporter 2 602 aa 32.3% 622 aa Compounds References
Rattus norvegicus Serotonin transporter 630 aa 35.2% 582 aa Compounds References
Rattus norvegicus GABA transporter 1 599 aa 33.4% 610 aa Compounds References
Rattus norvegicus Transporter 617 aa 33.4% 602 aa Compounds References
Rattus norvegicus Dopamine transporter 619 aa 31.8% 636 aa Compounds References
Macaca mulatta Serotonin transporter 630 aa 35.1% 604 aa Compounds References
Rattus norvegicus Norepinephrine transporter 597 aa 34.0% 595 aa Compounds References
Bos taurus Dopamine transporter 693 aa 31.0% 632 aa Compounds References
Macaca fascicularis Dopamine transporter 620 aa 31.9% 592 aa Compounds References
Bos taurus Sodium- and chloride-dependent glycine transporter 1 638 aa 31.3% 662 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0154 0.9287 0.9287
0.0243 0.2558 0.2553
0.1834 0.4481 0.4481
0.1574 0.513 0.513
0.0748 0.5222 0.5215
0.0374 0.7709 0.7709
0.1722 0.3146 0.3145
0.1787 0.5455 0.5455
0.1496 0.3765 0.3765
0.0668 0.6865 0.6865
0.1485 0.4792 0.4792
0.1789 0.4569 0.4569
0.0304 0.2539 0.2543
0.0793 0.4831 1
0.1156 1 1
0.1645 0.4419 0.4419
0.0748 0.5222 0.5215
0.1801 0.4563 0.4563
0.1223 0.746 0.746
0.1706 0.2941 0.2941
0.1234 0.2592 0.2592
0.0748 0.5222 0.5215
0.1789 0.4569 0.4569
0.1115 0.265 0.264
0.1242 0.2689 0.2689
0.1005 0.5157 0.4913
0.1848 0.3307 0.3307
0.1031 0.2779 0.2779
0.0304 0.2539 0.2543
0.2598 0.3868 0.3868
0.1255 0.2649 0.2649
0.1508 0.4248 0.4248
0.1493 0.3784 0.3784
0.22803 0.850252 0.850252
0.1337 0.8874 1
0.1191 0.4577 0.4577
0.0824 0.8403 1
0.089 0.2505 0.2505
0.054 0.574 1
0.2082 0.8078 0.8077
0.2041 1 1
0.0289 0.2998 0.4482
0.1191 0.4577 0.4577
0.1739 0.2812 0.2812
0.1848 0.3307 0.3307
0.1229 0.9395 0.9395
0.1663 0.2686 0.2686
0.1659 0.3153 0.3153
0.0382 0.2719 0.2704
0.029 0.3014 0.5644
0.1437 1 1
0.1223 0.746 0.746
0.1789 0.4569 0.4569
0.1045 1 1
0.1184 1 1
0.1052 0.4542 0.4542
0.1834 0.3501 0.3501
0.0345 0.2718 0.2691
0.1741 0.6339 0.6339
0.2197 1 1
0.1847 1 1
0.2022 0.3164 0.3164
0.1789 0.4569 0.4569
0.1779 0.4562 0.4562
0.1801 0.4563 0.4563
0.1848 0.3092 0.3092
0.1771 0.6069 0.6069
0.1182 0.9312 0.9312
0.0508 0.6228 1
0.1732 0.7136 0.7136
0.0345 0.2718 0.2691
0.1262 1 1
0.204 1 1
0.2138 0.3491 0.3491
0.1577 0.7426 0.7426
0.1228 0.7549 0.7549
0.0748 0.5222 0.5215
0.082 0.9189 1
0.1667 0.2975 0.2975
0.0651 0.761 1
0.1784 0.4547 0.4547
0.1691 0.277 0.277
0.0374 0.4604 1
0.0127 0.2608 0
0.1778 0.4784 0.4784
0.0345 0.2718 0.2691
0.1743 0.2894 0.2894
0.0304 0.2539 0.2543
0.0748 0.5222 0.5215
0.0374 1 1
0.1473 0.8289 0.8289
0.1206 0.4359 0.4359
0.1789 0.4569 0.4569
0.0671 0.5852 0.5852
0.1789 0.4569 0.4569
0.0123 0.682 0.682
0.1754 0.494 0.494
0.1789 0.4569 0.4569
0.1789 0.4569 0.4569
0.1789 0.4569 0.4569
0.0247 0.5593 1
0.0154 0.6749 0.7642
0.2197 1 1
0.1739 0.3957 0.3956
0.1848 0.3092 0.3092
0.0154 1 1
0.0154 1 1
0.1184 1 1
0.1191 1 1
0.0145 0.3971 0.7726
0.2138 0.3491 0.3491
0.0345 0.2718 0.2691
0.0811 0.8979 1
0.1834 0.4481 0.4481
0.0248 1 1
0.1657 0.4808 0.4807
0.170074 0.522126 0.522126
0.1031 0.2779 0.2779
0.0929 0.9516 1
0.014 0.6917 0.6917
0.1807 0.4222 0.4222
0.0944 1 1
0.203 1 1
0.0824 0.8403 1
0.0923 1 1
0.1307 0.8535 1
0.0626 1 1
0.1141 0.3959 0.3959
0.1031 0.2779 0.2779
0.0793 0.4831 1
0.1194 0.8247 0.8247
0.0944 1 1
0.175 0.6009 0.6009

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LOAG_06546 (Loa Loa (eye worm)), Sodium:neurotransmitter symporter family protein
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