Detailed view for LOAG_12358

Basic information

TDR Targets ID: 942106
Loa Loa (eye worm), hypothetical protein

Source Database / ID:  KEGG  

pI: 7.1403 | Length (AA): 702 | MW (Da): 78950 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01429   Methyl-CpG binding domain
PF15613   Williams-Beuren syndrome DDT (WSD), D-TOX E motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 84 5agq (A) 533 614 35.00 0 1 0.534158 -0.21
1 52 6ccg (A) 15 64 36.00 0.000055 0.91 0.457674 0.12
150 184 4fe8 (C) 375 409 57.00 0.46 0.01 0.564958 0.42
269 531 4c9b (B) 150 406 14.00 0 0.45 0.439144 -0.22
405 578 4tql (A) 26 200 13.00 0.22 0.04 0.365463 -0.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131570)

Species Accession Gene Product
Brugia malayi Bm1_46290   Bromodomain containing protein
Caenorhabditis elegans CELE_ZK783.4   Protein FLT-1
Drosophila melanogaster Dmel_CG10897   toutatis
Echinococcus granulosus EgrG_000895000   bromodomain adjacent to zinc finger domain
Echinococcus multilocularis EmuJ_000895000   bromodomain adjacent to zinc finger domain
Homo sapiens ENSG00000076108   bromodomain adjacent to zinc finger domain, 2A
Homo sapiens ENSG00000226266   bromodomain adjacent to zinc finger domain, 2B
Loa Loa (eye worm) LOAG_12358   hypothetical protein
Loa Loa (eye worm) LOAG_13083   hypothetical protein
Loa Loa (eye worm) LOAG_13007   hypothetical protein
Loa Loa (eye worm) LOAG_05113   hypothetical protein
Mus musculus ENSMUSG00000026987   bromodomain adjacent to zinc finger domain, 2B
Mus musculus ENSMUSG00000040054   bromodomain adjacent to zinc finger domain, 2A
Schistosoma japonicum Sjp_0100460   Conserved hypothetical protein
Schistosoma japonicum Sjp_0030660   ko:K01549 ATP synthase [EC3.6.3.14], putative
Schistosoma japonicum Sjp_0030670   Cleft lip and palate transmembrane protein 1-like protein, putative
Schistosoma japonicum Sjp_0311230   expressed protein
Schistosoma japonicum Sjp_0100450   hypothetical protein
Schistosoma mansoni Smp_170760   bromodomain containing protein
Schmidtea mediterranea mk4.006357.00   Bromodomain adjacent to zinc finger domain protein 2B
Schmidtea mediterranea mk4.006357.01   Toutatis
Schmidtea mediterranea mk4.012321.00   Toutatis

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Compounds References
Homo sapiens bromodomain adjacent to zinc finger domain, 2A Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0085 0.9228 1
0.007 0.257 0.2924
0.0075 0.2668 0.5484
0.0081 0.3495 0.3976
0.0079 0.2965 0.3408
0.0085 0.4323 0.4323
0.007 0.252 1
0.0063 0.4056 0.4056
0.0223 0.2617 0.9629
0.0083 0.3696 0.3813
0.0068 0.3888 0.3839
0.021 0.2518 0.3317
0.0778 0.3744 0.4591
0.1484 0.2546 0.5031
0.0073 0.2728 0.2665
0.0861 0.2565 0.7018
0.0069 0.9287 1
0.0069 0.9262 1
0.023 0.326 0.5492
0.0071 0.2736 0.313
0.0085 0.4013 1
0.0685 0.3144 0.3746
0.0085 0.3738 0.3738
0.016 0.4704 0.7577
0.0073 0.9262 1
0.0219 0.3861 0.3855
0.0071 0.278 0.3119
0.0069 0.9228 1
0.0085 0.6196 0.6229
0.0704 0.3339 0.3334
0.0085 0.9254 1
0.016 0.2737 0.4033
0.0077 0.3202 0.4745
0.0143 0.449 0.5594
0.0085 0.2521 0.7004
0.0073 0.9109 1
0.0211 0.2877 1
0.0085 0.5547 0.5547
0.0077 0.5058 0.5058
0.0085 0.9283 1
0.0156 0.4355 0.6231
0.0474 0.2881 0.326
0.0077 0.9228 1
0.0156 0.3567 0.3558
0.0152 0.3726 0.3726
0.0085 0.2501 0.2786
0.0931 0.556 1
0.0072 0.9262 1
0.0078 0.2782 0.2782
0.0085 0.409 0.5245
0.0147 0.3625 0.3625
0.0085 0.5332 0.5296
0.0078 0.3413 0.5284
0.0085 0.2591 0.2591
0.014 0.3711 0.4205
0.0085 0.4262 1
0.0085 0.2599 0.2599
0.0085 0.3898 1
0.0083 0.2616 0.3002
0.0085 0.2704 0.3536
0.0085 0.9254 1
0.0069 0.3284 0.326
0.0085 0.3366 1
0.007 0.267 0.2682
0.0132 0.3758 0.4155
0.014 0.5469 1
0.0441 0.2544 0.3113
0.0069 0.8099 0.8067
0.0253 0.3699 0.4227
0.0073 0.3737 1
0.0072 0.9254 1
0.0224 0.2855 1
0.0085 0.2673 0.3061
0.0085 0.3319 0.2844
0.0082 0.9239 1
0.0085 0.2687 0.2687
0.008 0.9213 1
0.0145 0.2806 0.2854
0.0085 0.4017 0.4003
0.0085 0.5106 0.5053
0.0085 0.9228 1
0.0085 0.6605 0.7727
0.0085 0.4134 0.4113
0.0143 0.4195 0.6606
0.0139 0.2513 0.2513
0.0083 0.5487 0.5407
0.0085 0.2773 0.317
0.0224 0.2958 0.6547
0.0066 0.2857 0.2968
0.0072 0.2632 0.3017
0.0226 0.5916 1
0.0085 0.2536 0.2514
0.0362 0.4238 0.8736
0.2278 0.4402 0.7601
0.1022 0.3149 0.5923
0.0073 0.3685 0.3685
0.0078 0.2605 1
0.0069 0.4014 0.4014
0.0456 0.2851 0.2851
0.0073 0.4465 0.4386
0.0081 0.3395 1
0.0462 0.2881 0.326
0.1002 0.5783 0.9401
0.0079 0.2501 0.2857
0.0085 0.9228 1
0.0076 0.3495 0.6909
0.0085 0.3366 1
0.0085 0.2501 0.2786
0.0071 0.6706 1
0.0078 0.3349 0.3349
0.0077 0.9283 1
0.0077 0.9164 1
0.0085 0.9213 1
0.0085 0.394 0.389
0.0075 0.4134 0.4056
0.0368 0.3713 1
0.0077 0.3256 1
0.007 0.5711 0.5711
0.0071 0.2624 0.2624
0.0085 0.2962 0.848
0.0085 0.5334 1
0.0068 0.9254 1
0.0082 0.3804 1
0.0073 0.2568 0.2723
0.0079 0.7812 0.7812
0.0144 0.2657 0.4482
0.0073 0.2713 0.2713
0.0085 0.9278 1
0.0085 0.4134 0.4056
0.104 0.391 0.7635
0.0085 0.9228 1
0.0085 0.4517 1
0.0085 0.3366 1
0.0085 0.8559 0.8559
0.0141 0.3372 0.4385
0.0642 0.2538 0.4034
0.007 0.2823 0.3226
0.0085 0.9228 1
0.0071 0.394 0.389
0.0085 0.9228 1
0.007 0.9157 1
0.0072 0.5974 0.5951
0.0085 0.9232 1
0.0085 0.4969 0.4916
0.0085 0.2594 0.2786
0.2142 0.7729 0.7728
0.0145 0.3522 0.3853
0.007 0.3366 1
0.0144 0.276 0.3141
0.1494 0.2501 0.3101
0.0143 0.2829 0.3675
0.0357 0.3054 1
0.0444 0.6097 1
0.0072 0.267 0.3056
0.0078 0.54 0.5219
0.007 0.2861 0.2861
0.0069 0.2678 0.5307
0.0079 0.2568 0.2568
0.0075 0.5325 0.5303
0.0085 0.9228 1
0.0072 0.4028 0.4028
0.0216 0.256 0.2659
0.1021 0.3384 0.5826
0.014 0.9283 1
0.0085 0.278 0.2682
0.0074 0.457 1
0.0151 0.4333 0.422
0.0069 0.9228 1
0.007 0.8995 0.8962
0.0085 0.2997 0.3433
0.0074 0.6318 0.6318
0.0081 0.442 0.6646
0.0068 0.2764 0.3095
0.0141 0.2579 0.3048
0.0074 0.9283 1
0.0082 0.9262 1
0.0081 0.2658 0.2658
0.0068 0.5325 0.5245
0.0069 0.3401 1
0.0069 0.3366 0.8884
0.0073 0.9255 1
0.007 0.333 0.4916
0.0078 0.4286 0.6897
0.0435 0.3187 1
0.0073 0.4014 0.4014
0.0965 0.2848 0.4532
0.0068 0.4134 0.4086
0.0085 0.2659 0.2659
0.1146 0.2596 0.4716
0.0068 0.4022 0.4022
0.0085 0.3926 0.3926
0.0142 0.2911 0.9625
0.007 0.2554 0.2906
0.0568 0.2709 0.3331
0.0364 0.283 0.3815
0.014 0.2513 0.2513
0.0085 0.2581 0.5245
0.0085 0.267 0.3056
0.0181 0.2577 0.3733
0.0085 0.9242 1
0.0085 0.3405 0.3031
0.0057 0.9254 1
0.0069 0.2533 1
0.0084 0.2578 0.2958
0.0085 0.253 0.2906
0.0146 0.4847 0.6942
0.0138 0.3067 1
0.007 0.3717 0.4209
0.0147 0.2904 0.2991
0.0085 0.9262 1
0.0085 0.2788 0.2788
0.0085 0.2501 0.2786
0.1224 0.2543 0.4692
0.0085 0.9262 1
0.0085 0.9213 1
0.0085 0.2829 0.2829
0.0073 0.4541 0.4517
0.0085 0.9228 1
0.007 0.2501 0.2824
0.2436 0.4403 0.7602
0.0064 0.9283 1
0.0085 0.9283 1
0.0085 0.4459 0.4459
0.0077 0.2621 0.2922
0.008 0.4014 0.6069
0.0085 0.3595 0.4056
0.0074 0.264 0.3015
0.0071 0.9228 1
0.0373 0.2522 1
0.0072 0.2622 0.3006
0.0155 0.4416 0.4355
0.013 0.2514 0.2732
0.0085 0.9213 1
0.0085 0.4028 0.4028
0.0072 0.359 1
0.0214 0.2602 0.3284
0.0073 0.3274 0.389
0.0072 0.2594 0.2947
0.0083 0.9172 1
0.0085 0.9283 1
0.0069 0.2765 0.2697
0.0142 0.2905 0.9679
0.0499 0.3427 0.3907
0.0085 0.3566 0.3806
0.0617 0.2855 0.3255
0.0072 0.2706 1
0.007 0.9262 1
0.0085 0.9297 1
0.0069 0.3704 0.5585
0.0206 0.9283 1
0.0076 0.4992 0.7936
0.0075 0.3894 1
0.0073 0.252 0.2647
0.0716 0.2892 0.3071
0.0144 0.276 0.3141
0.0446 0.2585 0.328
0.0708 0.3369 0.5896
0.0071 0.4358 0.4337
0.0079 0.9283 1
0.0143 0.3971 0.9455
0.0085 0.4155 0.412
0.0069 0.9254 1
0.0067 0.2904 0.2862
0.0305 0.3604 0.4238
0.0069 0.3772 0.3772
0.0082 0.3356 0.4152
0.007 0.403 0.4014
0.0078 0.2673 0.4914
0.0075 0.5325 0.5245
0.0072 0.3689 0.3689
0.0161 0.2639 0.3619
0.0085 0.9283 1
0.0152 0.3849 0.3991
0.0058 0.265 0.265
0.0289 0.3227 0.4554
0.0081 0.2745 0.2681
0.0085 0.9262 1
0.0076 0.4676 0.4596
0.0949 0.258 0.9858
0.0073 0.253 0.2906
0.0085 0.9262 1
0.0075 0.9283 1
0.0085 0.6818 1
0.0069 0.3553 0.3734
0.0727 0.3476 0.4167
0.007 0.2505 0.6396
0.0077 0.3983 0.4064
0.0078 0.9262 1
0.0069 0.2684 0.2592
0.0085 0.7573 0.7573
0.0085 0.2531 0.5939
0.0076 0.9283 1
0.0685 0.3144 0.3746
0.0386 0.5042 1
0.0076 0.2566 0.293
0.0071 0.9254 1
0.0083 0.5169 0.5148
0.0074 0.9228 1
0.0082 0.3478 0.3478
0.0078 0.9239 1
0.0138 0.7895 0.9196
0.0085 0.2572 0.2572
0.0075 0.9266 1
0.0085 0.3432 0.3107
0.021 0.2714 0.3664
0.0068 0.7409 0.7409
0.0227 0.2774 0.3083
0.0222 0.4583 0.7246
0.0085 0.9228 1
0.052 0.3129 0.8263
0.0078 0.2594 0.2975
0.0076 0.352 0.352
0.0085 0.3225 0.3707
0.0227 0.3039 0.6869
0.0085 0.352 0.352
0.0085 0.2598 0.2598
0.0147 0.3559 0.4551
0.0143 0.3638 1
0.0222 0.7112 0.7097
0.0071 0.2561 0.2561
0.0079 0.2887 1
0.0085 0.9294 1
0.1494 0.2501 0.3101
0.0211 0.4016 0.688
0.0085 0.9254 1
0.008 0.352 0.352
0.0071 0.3854 0.3804
0.007 0.2602 0.2978
0.0085 0.2501 0.2786
0.0085 0.9228 1
0.0079 0.2506 0.2446
0.0085 0.9262 1
0.0069 0.5826 0.5776
0.0139 0.3188 0.3413
0.0572 0.2576 0.2936
0.0085 0.9254 1
0.1002 0.3239 0.5743
0.0075 0.3366 0.4521
0.0071 0.7467 0.7467
0.0079 0.9266 1
0.0085 0.9213 1
0.0202 0.3571 0.4892
0.0662 0.2558 0.9076
0.0512 0.2776 0.6915
0.0146 0.2824 0.4225
0.0071 0.9272 1
0.0085 0.3366 1
0.0085 0.2501 0.2501
0.0085 0.2506 0.2446
0.0213 0.4363 0.5571
0.0085 0.9228 1
0.0085 0.253 0.2906
0.0077 0.2833 0.3068
0.0131 0.2569 0.2569
0.1494 0.2501 0.3101
0.0085 0.3535 1
0.0085 0.2501 0.2857
0.0073 0.253 0.2906
0.0082 0.2675 0.3044
0.0085 0.2526 0.2903
0.0085 0.9228 1
0.0085 0.3358 0.3312
0.0085 0.9262 1
0.0085 0.3495 1
0.0085 0.9228 1
0.0143 0.2679 0.2899
0.1304 0.5066 1
0.0215 0.2999 0.978
0.0071 0.3225 0.3225
0.0085 0.3495 0.8764
0.0078 0.2794 0.3136
0.0085 0.4323 0.4323
0.0085 0.3495 0.571
0.0159 0.9228 1
0.0085 0.608 0.6046
0.0068 0.3354 0.3335
0.0085 0.5809 0.5809
0.0159 0.9228 1
0.0085 0.9228 1
0.0244 0.6392 0.6392
0.0075 0.6692 1
0.0309 0.3577 0.6863
0.0079 0.6554 0.6554
0.007 0.2789 0.2761
0.0085 0.253 0.2535
0.0085 0.3709 0.6399
0.0085 0.2501 0.2786
0.008 0.7393 1
0.0243 0.4885 0.4885
0.104 0.391 0.7635
0.0085 0.9262 1
0.0085 0.3366 1
0.0078 0.2545 0.2676
0.0073 0.9266 1
0.007 0.3555 0.4201
0.0237 0.2993 0.3261
0.0085 0.9213 1
0.0081 0.9283 1
0.0085 0.9228 1
0.015 0.3438 0.6082
0.0085 0.5216 0.5216
0.0085 0.31 0.3551
0.0085 0.252 0.3768
0.0085 0.4069 0.4056
0.0151 0.3303 0.5099
0.0072 0.3495 0.4616
0.0078 0.4113 0.4113
0.007 0.9228 1
0.0223 0.269 0.3442
0.0072 0.4155 0.412
0.007 0.5208 0.5208
0.057 0.3336 1
0.0081 0.4504 0.4504
0.0073 0.2587 0.2547
0.0159 0.9228 1
0.0085 0.2525 0.29
0.0068 0.2504 0.2436
0.0376 0.4923 1
0.0079 0.2511 0.4187
0.0166 0.5941 1
0.0073 0.382 1
0.0085 0.9254 1
0.0085 0.9254 1
0.0743 0.2691 0.4168
0.0085 0.3926 0.3926
0.0085 0.379 1
0.0294 0.3635 0.4636
0.0159 0.9228 1
0.0194 0.3302 0.3875
0.0143 0.3351 0.386
0.0081 0.2672 0.2672
0.0081 0.2589 1
0.0591 0.2574 0.3293
0.0085 0.9232 1
0.0085 0.2708 0.7851
0.0244 0.2721 0.4992
0.0074 0.6692 1
0.0081 0.2698 0.3102
0.0085 0.6383 0.6335
0.0809 0.2694 0.307
0.0158 0.482 0.5644
0.007 0.3077 0.3061
0.0085 0.9254 1
0.0085 0.9262 1
0.0076 0.2797 0.5216
0.0218 0.2598 0.4431
0.0077 0.2702 1
0.0081 0.5736 0.5636
0.0085 0.394 0.389
0.0564 0.3468 0.6213
0.0072 0.2594 0.2947
0.0072 0.3064 0.3027
0.0085 0.9228 1
0.0243 0.2574 1
0.0085 0.3279 0.3728
0.0085 0.9228 1
0.0085 0.505 0.7469
0.0085 0.2704 0.3536
0.007 0.2501 0.2857
0.0085 0.9164 1
0.0069 0.3535 0.4084
0.0085 0.4512 0.5089
0.0076 0.9262 1
0.007 0.6692 1
0.0076 0.4758 0.4758
0.0297 0.2813 0.6104
0.008 0.3413 1
0.0085 0.3413 1
0.0085 0.3005 0.3005
0.0932 0.311 0.7649
0.0081 0.3811 0.3777
0.0085 0.2594 0.2947
0.0154 0.4531 0.4531
0.0085 0.2674 0.3014
0.0085 0.9228 1
0.0085 0.9254 1
0.0083 0.3495 0.665
0.0465 0.3134 0.7299
0.0159 0.2601 0.5535
0.007 0.3496 0.3979
0.0139 0.2726 1
0.0068 0.2511 0.3369
0.0289 0.2544 0.7844
0.0142 0.4476 0.6392
0.0069 0.2622 0.2986
0.0085 0.252 1
0.065 0.2628 0.2995
0.0085 0.9228 1
0.0082 0.3413 0.3934
0.0577 0.2857 0.326
0.0085 0.2501 0.2856
0.1663 0.8482 0.9061
0.0085 0.9254 1
0.0069 0.7903 0.7903
0.0082 0.252 0.4056
0.007 0.4018 1
0.1052 0.7009 0.9733
0.0286 0.2641 0.2639
0.0144 0.3436 0.3436
0.0085 0.6357 0.6357
0.0293 0.2781 0.3324
0.0085 0.5125 0.5089
0.0085 0.3366 1
0.007 0.4783 1
0.0085 0.9157 1
0.0085 0.9262 1
0.0085 0.9254 1
0.0085 0.3191 0.3188
0.0085 0.263 0.263
0.0285 0.2547 0.7606
0.0085 0.2842 0.2946
0.0085 0.3366 1
0.0144 0.3936 0.5822
0.0085 0.253 0.2906
0.0219 0.2528 0.4746
0.0075 0.2506 0.2446
0.0139 0.2869 0.2827
0.0085 0.409 1
0.0074 0.3036 0.3036
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