pI: 7.7276 |
Length (AA): 454 |
MW (Da): 51140 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
20 | 96 | 3lf5 (A) | 57 | 133 | 55.00 | 0 | 1 | 0.919704 | -1.06 |
137 | 453 | 1krh (A) | 31 | 334 | 16.00 | 0 | 1 | 0.851338 | 0.31 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127870)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G09680 | reduced lateral root formation protein |
Babesia bovis | BBOV_I004720 | cytochrome b5-like Heme/Steroid binding domain containing protein |
Brugia malayi | Bm1_26075 | Cytochrome b5-like Heme/Steroid binding domain containing protein |
Candida albicans | CaO19.4522 | similar to A. thaliana F17I14_130 |
Candida albicans | CaO19.11997 | similar to A. thaliana F17I14_130 |
Caenorhabditis elegans | CELE_Y52B11A.3 | Protein Y52B11A.3, isoform B |
Dictyostelium discoideum | DDB_G0275647 | cytochrome b5 domain-containing protein |
Drosophila melanogaster | Dmel_CG11257 | CG11257 gene product from transcript CG11257-RA |
Giardia lamblia | GL50803_9089 | Cytochrome B5, outer mitochondrial membrane |
Giardia lamblia | GL50803_27747 | Flavohemoprotein B5+B5R |
Giardia lamblia | GL50803_33870 | Hypothetical protein |
Homo sapiens | 51167 | cytochrome b5 reductase 4 |
Leishmania braziliensis | LbrM.26.1450 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_261410.1 | cytochrome b5-like Heme/Steroid binding domain containing protein, putative |
Leishmania infantum | LinJ.26.1410 | hypothetical protein, conserved |
Leishmania major | LmjF.26.1430 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.26.1430 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_02505 | cytochrome b5 reductase 4 |
Mus musculus | ENSMUSG00000032872 | cytochrome b5 reductase 4 |
Neospora caninum | NCLIV_056850 | hypothetical protein |
Oryza sativa | 4342780 | Os07g0232200 |
Onchocerca volvulus | OVOC1602 |
|
Plasmodium berghei | PBANKA_0819100 | cytochrome b5, putative |
Plasmodium falciparum | PF3D7_0918100 | cytochrome b5-like heme/steroid binding protein, putative |
Plasmodium knowlesi | PKNH_0716100 | heme binding protein, putative |
Plasmodium vivax | PVX_099325 | cytochrome b5-like Heme/Steroid binding domain containing protein |
Plasmodium yoelii | PY07000 | cytochrome B5, outer mitochondrial membrane |
Saccharomyces cerevisiae | YMR073C | Irc21p |
Schmidtea mediterranea | mk4.002226.03 | Putative cytochrome b5 |
Trypanosoma brucei gambiense | Tbg972.7.390 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.520 | cytochrome b5-like Heme/Steroid binding domain containing protein, putative |
Trypanosoma congolense | TcIL3000_7_210 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.410049.20 | cytochrome b5-like Heme/Steroid binding domain containing protein, putative |
Trypanosoma cruzi | TcCLB.506287.30 | cytochrome b5-like Heme/Steroid binding domain containing protein, putative |
Toxoplasma gondii | TGME49_313580 | cytochrome b5 family heme/steroid binding domain-containing protein |
Toxoplasma gondii | TGME49_313590 | hypothetical protein |
Trichomonas vaginalis | TVAG_203330 | cytochrome B5, putative |
Trichomonas vaginalis | TVAG_063210 | cytochrome B5 isoform 1, putative |
Trichomonas vaginalis | TVAG_032980 | cytochrome B5 isoform 1, putative |
Trichomonas vaginalis | TVAG_329360 | flavohemoprotein B5/b5r, putative |
Trichomonas vaginalis | TVAG_274060 | fatty acid desaturase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.520 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.520 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.520 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.520 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0819100 | Plasmodium berghei | Slow | plasmo |
TGME49_313590 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_313580 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_313590 | Toxoplasma gondii | Probably essential | sidik |
TGME49_313580 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.