Detailed view for LOAG_03887

Basic information

TDR Targets ID: 942350
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.4328 | Length (AA): 605 | MW (Da): 67280 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00102   Protein-tyrosine phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0004725   protein tyrosine phosphatase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 509 2jjd (A) 211 691 24.00 0.00000000032 1 0.965069 0.4
222 511 3s3e (A) 23 305 62.00 0 1 1.30134 -1.32
224 578 1ygr (A) 607 947 33.00 0.0000000029 1 0.971177 -0.19
227 517 2nlk (A) 830 1130 42.00 0 1 0.948992 -0.68
260 548 1lar (B) 1340 1619 39.00 0 1 0.979386 -0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132503)

Species Accession Gene Product
Brugia malayi Bm1_42025   Protein-tyrosine phosphatase
Candida albicans CaO19.13722   phosphotyrosine-specific protein phosphatase
Candida albicans CaO19.6365   phosphotyrosine-specific protein phosphatase
Caenorhabditis elegans CELE_F44G4.8   Protein DEP-1, isoform B
Drosophila melanogaster Dmel_CG1817   Protein tyrosine phosphatase 10D
Drosophila melanogaster Dmel_CG6899   Protein tyrosine phosphatase 4E
Homo sapiens ENSG00000127329   protein tyrosine phosphatase, receptor type, B
Loa Loa (eye worm) LOAG_03887   hypothetical protein
Loa Loa (eye worm) LOAG_12391   hypothetical protein
Loa Loa (eye worm) LOAG_10550   hypothetical protein
Loa Loa (eye worm) LOAG_15592   hypothetical protein
Mus musculus ENSMUSG00000020154   protein tyrosine phosphatase, receptor type, B
Onchocerca volvulus OVOC10784  
Schistosoma japonicum Sjp_0127660   ko:K05694 protein tyrosine phosphatase, receptor type, B, putative
Schmidtea mediterranea mk4.003151.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein tyrosine phosphatase, receptor type, B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1174 0.9405 1
0.2076 0.9404 1
0.2155 0.9438 1
0.2032 0.9408 1
0.0334 0.5393 1
0.259 0.928 1
0.0439 0.9405 1
0.2095 0.9278 1
0.0097 0.3613 0.3544
0.0829 0.5681 1
0.0534 0.4827 1
0.0351 0.5921 1
0.2145 0.8436 1
0.3019 0.9358 1
0.1457 0.9418 1
0.0246 0.6132 1
0.0728 0.9397 1
0.2032 0.9408 1
0.1057 0.9404 1
0.2155 0.9438 1
0.0097 0.6324 0.6324
0.0185 0.9358 1
0.0347 0.9358 1
0.1785 0.9256 1
0.2219 0.9405 1
0.1066 0.9358 1
0.018 0.4384 0.4384
0.0011 1 0.5
0.3153 0.9358 1
0.3406 0.9358 1
0.0557 0.6498 0.6171
0.2498 0.9358 1
0.0576 0.3097 0.552
0.3004 0.9405 1
0.0097 0.9358 1
0.0097 0.6324 0.6324
0.0905 0.9402 1
0.0728 0.9397 1
0.1813 0.9423 1
0.1576 0.9448 1
0.0332 0.9358 1
0.0096 0.9023 1
0.0097 0.9358 1
0.1228 0.9437 1
0.0266 0.3082 0.517
0.0328 0.9358 1
0.0372 0.3709 0.3062
0.0342 0.9381 1
0.0096 0.9023 1
0.2597 0.9358 1
0.216 0.9272 1
0.0405 0.9268 1
0.242 0.9437 1
0.3004 0.9405 1
0.3627 0.9438 1
0.0271 0.3048 0.6612
0.2043 0.2788 0.288
0.0272 0.5028 0.5028
0.0711 0.4937 0.4198
0.2596 0.9358 1
0.051 0.9358 1
0.2278 0.9397 1
0.018 0.4384 0.4384
0.2016 0.9397 1
0.2529 0.9438 1
0.245 0.9358 1
0.2596 0.9358 1
0.0346 0.28 0.2775
0.242 0.9437 1
0.0334 0.5393 1
0.0011 1 1
0.2343 0.9436 1
0.0894 0.6888 0.6888
0.0332 0.6274 1
0.0097 0.9358 1
0.1837 0.9429 1
0.0097 0.9358 1
0.0905 0.9402 1
0.0248 0.364 1
0.2076 0.9404 1
0.0011 1 0.5
0.0334 0.5393 1
0.018 0.4384 0.4384
0.0346 0.28 0.2775
0.2029 0.9358 1
0.0342 0.9358 1
0.0097 0.9358 1
0.0664 0.2942 0.5255
0.1965 0.9391 1
0.1057 0.9404 1
0.0456 0.4882 0.437
0.0961 0.9445 1
0.0332 0.9358 1
0.2072 0.9435 1
0.0256 0.5427 0.5427
0.065 0.9387 1
0.2043 0.2788 0.288
0.0346 0.28 0.2775
0.0911 0.3096 0.7129
0.0097 0.9358 1
0.3627 0.9438 1
0.0534 0.4827 1
0.0734 0.9358 1
0.0097 0.7666 0.7659
0.0339 0.4497 1
0.0894 0.6888 0.6888
0.0194 0.2655 0.2655
0.1683 0.9358 1
0.0534 0.4827 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_03887 (Loa Loa (eye worm)), hypothetical protein
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