pI: 6.935 |
Length (AA): 284 |
MW (Da): 31453 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 282 | 2iex (A) | 10 | 266 | 29.00 | 0 | 1 | 1.21467 | -0.04 |
12 | 281 | 1dci (A) | 55 | 321 | 48.00 | 0 | 1 | 1.5901 | -0.89 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129459)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G43280 | delta(3,5),delta(2,4)-dienoyl-CoA isomerase 1 |
Brugia malayi | Bm1_35505 | enoyl-CoA hydratase/isomerase family protein |
Candida albicans | CaO19.14122 | enoyl-CoA hydratase/isomerase family protein similar to N. crassa sequence (CAD21495) |
Candida albicans | CaO19.6830 | enoyl-CoA hydratase/isomerase family protein similar to N. crassa sequence (CAD21495) |
Caenorhabditis elegans | CELE_Y25C1A.13 | Protein Y25C1A.13 |
Caenorhabditis elegans | CELE_F58A6.1 | Protein F58A6.1 |
Dictyostelium discoideum | DDB_G0282261 | Delta-Delta-dienoyl-CoA isomerase |
Drosophila melanogaster | Dmel_CG9577 | CG9577 gene product from transcript CG9577-RA |
Homo sapiens | ENSG00000104823 | enoyl CoA hydratase 1, peroxisomal |
Leishmania braziliensis | LbrM.18.0640 | peroxisomal enoyl-coa hydratase, putative |
Leishmania donovani | LdBPK_180580.1 | peroxisomal enoyl-coa hydratase, putative |
Leishmania infantum | LinJ.18.0580 | peroxisomal enoyl-coa hydratase, putative |
Leishmania major | LmjF.18.0580 | peroxisomal enoyl-coa hydratase, putative |
Leishmania mexicana | LmxM.18.0580 | peroxisomal enoyl-coa hydratase, putative |
Loa Loa (eye worm) | LOAG_07056 | enoyl-CoA hydratase/isomerase |
Mycobacterium leprae | ML0120c | Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-coA hydratase) (crotonase) |
Mus musculus | ENSMUSG00000053898 | enoyl coenzyme A hydratase 1, peroxisomal |
Mycobacterium tuberculosis | Rv3774 | Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) |
Neospora caninum | NCLIV_054880 | Short chain enoyl-CoA hydratase (EC 4.2.1.17), related |
Oryza sativa | 4327232 | Os01g0925200 |
Onchocerca volvulus | OVOC11591 |
|
Schmidtea mediterranea | mk4.013378.00 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial |
Trypanosoma cruzi | TcCLB.511277.210 | peroxisomal enoyl-coa hydratase, putative |
Toxoplasma gondii | TGME49_310830 | enoyl-CoA hydratase/isomerase family protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3841 | Mycobacterium tuberculosis | non-essential | nmpdr |
CELE_F58A6.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y25C1A.13 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_310830 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.