Detailed view for LOAG_03524

Basic information

TDR Targets ID: 943356
Loa Loa (eye worm), hypothetical protein

Source Database / ID:  KEGG  

pI: 8.064 | Length (AA): 616 | MW (Da): 70179 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 13

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00209   Sodium:neurotransmitter symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005328   neurotransmitter:sodium symporter activity  
GO:0006836   neurotransmitter transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 573 4xp4 (A) 25 596 25.00 0 0.99 1.21435 -0.34
22 569 5i6x (A) 79 611 27.00 0 1 1.15061 -0.07
132 174 5fef (A) 19 59 41.00 0.46 0.08 0.262805 1.79

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_192392)

Species Accession Gene Product
Brugia malayi Bm1_30320   Sodium:neurotransmitter symporter family protein 1, putative
Caenorhabditis elegans CELE_W03G9.1   Protein SNF-1
Loa Loa (eye worm) LOAG_03524   hypothetical protein


No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus GABA transporter 2 602 aa 26.1% 583 aa Compounds References
Rattus norvegicus GABA transporter 614 aa 25.1% 566 aa Compounds References
Rattus norvegicus GABA transporter 1 599 aa 24.2% 545 aa Compounds References
Rattus norvegicus Norepinephrine transporter 597 aa 25.0% 551 aa Compounds References

Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0345 0.2718 0.2691
0.0345 0.2718 0.2691
0.0345 0.2718 0.2691
0.0304 0.2539 0.2543
0.0304 0.2539 0.2543
0.0382 0.2719 0.2704
0.0304 0.2539 0.2543
0.0243 0.2558 0.2553
0.0345 0.2718 0.2691


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_03524 (Loa Loa (eye worm)), hypothetical protein
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