Detailed view for LOAG_08923

Basic information

TDR Targets ID: 943538
Loa Loa (eye worm), MH2 domain-containing protein

Source Database / ID:  KEGG  

pI: 7.715 | Length (AA): 593 | MW (Da): 64985 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03165   MH1 domain
PF03166   MH2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005667   transcription factor complex  
GO:0005622   intracellular  
GO:0005515   protein binding  
GO:0003700   transcription factor activity  
GO:0007179   transforming growth factor beta receptor signaling pathway  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
79 200 5mey (A) 15 137 70.00 0 1 1.14333 -1.53
79 199 5nm9 (A) 9 130 69.00 0 1 1.14435 -1.88
328 581 1dd1 (B) 288 541 57.00 0 1 1.05893 -0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_131742)

Species Accession Gene Product
Brugia malayi Bm1_38760   MH2 domain containing protein
Drosophila melanogaster Dmel_CG1775   Medea
Echinococcus granulosus EgrG_000217400   Smad4
Echinococcus multilocularis EmuJ_000217400   Smad4
Homo sapiens ENSG00000141646   SMAD family member 4
Loa Loa (eye worm) LOAG_08923   MH2 domain-containing protein
Mus musculus ENSMUSG00000024515   SMAD family member 4
Schistosoma japonicum Sjp_0030450   ko:K04501 SMAD, mothers against DPP 4, putative
Schistosoma mansoni Smp_033950.1   Smad4
Schistosoma mansoni Smp_033950.2   Smad4
Schistosoma mansoni Smp_033950.3   Smad4
Schmidtea mediterranea mk4.017761.00   Mothers against decapentaplegic homolog 4
Schmidtea mediterranea mk4.006788.00  
Schmidtea mediterranea mk4.016540.01   Mothers against decapentaplegic homolog 4
Schmidtea mediterranea mk4.012852.00  
Schmidtea mediterranea mk4.016348.00   Smad4
Schmidtea mediterranea mk4.003801.02  
Schmidtea mediterranea mk4.022472.00  
Schmidtea mediterranea mk4.033489.00  
Schmidtea mediterranea mk4.012852.01   Mothers against decapentaplegic homolog 4


No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08923 (Loa Loa (eye worm)), MH2 domain-containing protein
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