Detailed view for LOAG_06191

Basic information

TDR Targets ID: 943896
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.4444 | Length (AA): 753 | MW (Da): 84477 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00018   SH3 domain
PF14604   Variant SH3 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 81 3q8t (A) 176 258 15.00 0.67 0.16 0.425442 -2.59
3 67 5wst (A) 867 931 22.00 0.75 0.03 0.506521 -2.73
24 93 5wsu (C) 788 850 49.00 0.043 0.39 0.730561 -2.37
44 114 5xis (A) 117 187 37.00 0.11 0.39 0.78389 -3.19
453 524 1j3t (A) 1 66 52.00 0.000019 1 0.650218 -0.43
470 521 4iim (A) 918 968 55.00 0.000001 1 0.779657 -0.89
470 526 5vei (A) 868 924 46.00 0.00019 1 0.689297 -0.72
568 635 2d8h (A) 9 79 40.00 0 1 0.438105 -0.34
570 635 2d8h (A) 17 80 50.00 0.0000073 0.99 0.513249 -0.05
572 628 2d1x (C) 1 58 46.00 0.00007 0.99 0.687297 -0.81
577 629 1sem (A) 157 210 40.00 0 0.99 0.483185 -0.75
579 688 6b25 (A) 6 116 39.00 0.000016 1 0.392682 -0.05
691 751 2js0 (A) 1 57 35.00 0 1 0.464809 -1.46
692 751 1oeb (A) 0 54 48.00 0 1 0.569481 -1.23
695 733 3tvt (A) 603 646 60.00 0.27 0.92 0.574393 0.41
700 752 3jv3 (A) 1156 1204 53.00 0.000069 1 0.697985 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130570)

Species Accession Gene Product
Brugia malayi Bm1_02740   hypothetical protein
Brugia malayi Bm1_02735   Variant SH3 domain containing protein
Caenorhabditis elegans CELE_Y116A8C.36   Protein ITSN-1, isoform C
Drosophila melanogaster Dmel_CG1099   Dynamin associated protein 160
Echinococcus granulosus EgrG_000513400   intersectin 2
Echinococcus multilocularis EmuJ_000007500   dynamin associated protein
Echinococcus multilocularis EmuJ_000513400   intersectin 2
Homo sapiens ENSG00000205726   intersectin 1 (SH3 domain protein)
Homo sapiens ENSG00000198399   intersectin 2
Loa Loa (eye worm) LOAG_06192   hypothetical protein
Loa Loa (eye worm) LOAG_06191   hypothetical protein
Loa Loa (eye worm) LOAG_13437   hypothetical protein
Mus musculus ENSMUSG00000022957   intersectin 1 (SH3 domain protein 1A)
Mus musculus ENSMUSG00000020640   intersectin 2
Onchocerca volvulus OVOC4084  
Schistosoma japonicum Sjp_0124170   Intersectin-1, putative
Schistosoma japonicum Sjp_0037040   Intersectin-1, putative
Schistosoma mansoni Smp_135790   dynamin-associated protein
Schmidtea mediterranea mk4.016198.03  
Schmidtea mediterranea mk4.002446.04  
Schmidtea mediterranea mk4.006714.00  
Schmidtea mediterranea mk4.009085.00  
Schmidtea mediterranea mk4.000534.02  
Schmidtea mediterranea mk4.005570.00  
Schmidtea mediterranea mk4.003200.00  
Schmidtea mediterranea mk4.028620.01  
Schmidtea mediterranea mk4.022872.01  
Schmidtea mediterranea mk4.006003.00  
Schmidtea mediterranea mk4.002296.04  
Schmidtea mediterranea mk4.028620.00  
Schmidtea mediterranea mk4.010573.00  
Schmidtea mediterranea mk4.003200.01  
Schmidtea mediterranea mk4.026915.01  
Schmidtea mediterranea mk4.016198.04  
Schmidtea mediterranea mk4.003200.05  
Schmidtea mediterranea mk4.000703.01  
Schmidtea mediterranea mk4.010573.01  
Schmidtea mediterranea mk4.003200.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0282 0.283 0.4202
0.0322685 0.273741 0.262341
0.0029 0.4037 0.4037
0.0061 1 1
0.0282 0.283 0.4202
0.0068 0.2794 0.2794
0.0137 0.3036 0.3036
0.00394418 0.278418 0.262031
0.0065 0.3464 0.32
0.0336199 0.276589 0.265254
0.0048 0.281 0.281
0.0075 0.2576 0.2576
0.0048 0.3625 0.3625
0.0059 0.3 0.3006
0.0027 0.3179 0.3179
0.0027 0.3179 0.3179
0.0029 0.4037 0.4037
0.0064 0.3347 0.3362
0.0378 0.315 0.3101
0.0065 0.3464 0.32
0.0137 0.2846 0.2741
0.0039 0.2713 0.2713
0.00394418 0.278418 0.262031
0.0351989 0.270507 0.26116
0.0039 0.2713 0.2713

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_06191 (Loa Loa (eye worm)), hypothetical protein
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