Detailed view for LOAG_03696

Basic information

TDR Targets ID: 943997
Loa Loa (eye worm), ribose 5-phosphate isomerase
Source Database / ID:  KEGG  

pI: 9.3341 | Length (AA): 143 | MW (Da): 15899 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06026   Ribose 5-phosphate isomerase A (phosphoriboisomerase A)

Gene Ontology

Mouse over links to read term descriptions.
GO:0009052   pentose-phosphate shunt, non-oxidative branch  
GO:0004751   ribose-5-phosphate isomerase activity  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 128 1uj6 (A) 113 227 46.00 0 1 1.3055 0.15
1 129 3hhe (A) 131 253 38.00 0 1 1.2215 -0.04
1 124 3enq (A) 108 217 35.00 0 1 1.17893 -0.13
1 133 1xtz (A) 134 264 41.00 0 1 1.35647 -0.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127414)

Species Accession Gene Product
Arabidopsis thaliana AT2G01290   ribose 5-phosphate isomerase A
Arabidopsis thaliana AT3G04790   ribose 5-phosphate isomerase A
Arabidopsis thaliana AT1G71100   ribose 5-phosphate isomerase A
Babesia bovis BBOV_III002460   ribose 5-phosphate isomerase A family protein
Brugia malayi Bm1_57600   ribose 5-phosphate isomerase
Candida albicans CaO19.1701   similar to S. cerevisiae RKI1 (YOR095C) pentose phosphate shunt enzyme ribose-5-phosphate ketol-isomerase
Candida albicans CaO19.9268   similar to S. cerevisiae RKI1 (YOR095C) pentose phosphate shunt enzyme ribose-5-phosphate ketol-isomerase
Caenorhabditis elegans CELE_B0280.3   Protein RPIA-1
Chlamydia trachomatis CT_213   ribose-5-phosphate isomerase A
Dictyostelium discoideum DDB_G0276711   ribose-5-phosphate isomerase
Drosophila melanogaster Dmel_CG30410   Ribose-5-phosphate isomerase
Escherichia coli b2914   ribose 5-phosphate isomerase, constitutive
Echinococcus granulosus EgrG_001185200   integrator complex subunit 2
Echinococcus granulosus EgrG_001185300   ribose 5 phosphate isomerase
Echinococcus multilocularis EmuJ_001185300   ribose 5 phosphate isomerase
Echinococcus multilocularis EmuJ_001185200   integrator complex subunit 2
Homo sapiens ENSG00000153574   ribose 5-phosphate isomerase A
Loa Loa (eye worm) LOAG_04787   hypothetical protein
Loa Loa (eye worm) LOAG_03696   ribose 5-phosphate isomerase
Mus musculus ENSMUSG00000053604   ribose 5-phosphate isomerase A
Neospora caninum NCLIV_015970   Ribose 5-phosphate isomerase A (EC 5.3.1.6), related
Oryza sativa 4342543   Os07g0176900
Oryza sativa 4335430   Os04g0306400
Plasmodium berghei PBANKA_1114200   ribose-5-phosphate isomerase, putative
Plasmodium falciparum PF3D7_0514600   ribose-5-phosphate isomerase, putative
Plasmodium knowlesi PKNH_1018500   ribose-5-phosphate isomerase, putative
Plasmodium vivax PVX_080515   ribose 5-phosphate epimerase, putative
Plasmodium yoelii PY07185   ribose 5-phosphate isomerase
Saccharomyces cerevisiae YOR095C   ribose-5-phosphate isomerase RKI1
Schistosoma japonicum Sjp_0214860   ko:K01807 ribose 5-phosphate isomerase A [EC5.3.1.6A], putative
Schistosoma japonicum Sjp_0012910   Integrator complex subunit 2, putative
Schistosoma japonicum Sjp_0134990   Ribose-5-phosphate isomerase, putative
Schistosoma mansoni Smp_148770   ribose-5-phosphate isomerase
Schmidtea mediterranea mk4.029320.00  
Toxoplasma gondii TGME49_239310   ribulose 5-phosphate isomerase
Treponema pallidum TP0616   ribose-5-phosphate isomerase A
Theileria parva TP03_0628   ribose 5-phosphate epimerase, putative

Essentiality

LOAG_03696 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YOR095C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1114200 Plasmodium berghei Essential plasmo
TGME49_239310 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LOAG_03696 (Loa Loa (eye worm)), ribose 5-phosphate isomerase
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