pI: 4.2276 |
Length (AA): 362 |
MW (Da): 40857 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_131153)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_35145 | PAN domain containing protein |
Brugia malayi | Bm1_27340 | mKIAA0176 protein |
Caenorhabditis elegans | CELE_H42K12.3 | Protein H42K12.3 |
Caenorhabditis elegans | CELE_C52B11.2 | Protein TAG-303 |
Drosophila melanogaster | Dmel_CG32810 | insomniac |
Homo sapiens | ENSG00000167977 | potassium channel tetramerization domain containing 5 |
Homo sapiens | ENSG00000180901 | potassium channel tetramerization domain containing 2 |
Loa Loa (eye worm) | LOAG_11388 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06628 | potassium channel tetramerisation domain containing 5 |
Loa Loa (eye worm) | LOAG_11387 | hypothetical protein |
Mus musculus | ENSMUSG00000016946 | potassium channel tetramerisation domain containing 5 |
Mus musculus | ENSMUSG00000016940 | potassium channel tetramerisation domain containing 2 |
Onchocerca volvulus | OVOC5777 |
|
Schmidtea mediterranea | mk4.003418.00 | |
Schmidtea mediterranea | mk4.008345.00 | |
Trypanosoma cruzi | TcCLB.508915.9 | hypothetical protein, conserved |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.