Detailed view for LOAG_04505

Basic information

TDR Targets ID: 945028
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.4376 | Length (AA): 339 | MW (Da): 39013 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06325   Ribosomal protein L11 methyltransferase (PrmA)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  
GO:0006479   protein amino acid methylation  

Metabolic Pathways

FoxO signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 338 4y30 (B) 25 373 33.00 0 1 1.36665 -0.71
35 338 3q7e (A) 41 352 66.00 0 1 1.74916 -1.4
61 171 1kpg (A) 61 165 23.00 0 0.43 0.475734 0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127422)

Species Accession Gene Product
Arabidopsis thaliana AT2G19670   protein arginine N-methyltransferase 1
Arabidopsis thaliana AT4G29510   arginine methyltransferase 11
Babesia bovis BBOV_III010530   conserved hypothetical protein
Brugia malayi Bm1_25900   hypothetical protein
Candida albicans CaO19.10801   hnRNP methyltransferase.
Candida albicans CaO19.3291   hnRNP methyltransferase.
Caenorhabditis elegans CELE_Y113G7B.17   Protein PRMT-1
Cryptosporidium hominis Chro.80547   ARF GAP-like zinc finger-containing protein (ZIGA2)
Cryptosporidium parvum cgd8_4760   arginine n-methyltransferase
Dictyostelium discoideum DDB_G0291556   protein arginine methyltransferase
Drosophila melanogaster Dmel_CG6554   Arginine methyltransferase 1
Echinococcus granulosus EgrG_001035900   protein arginine N methyltransferase 8
Echinococcus granulosus EgrG_000911500   protein arginine methyltransferase
Entamoeba histolytica EHI_202470   arginine N-methyltransferase protein, putative
Entamoeba histolytica EHI_152460   hypothetical protein
Echinococcus multilocularis EmuJ_000911500   protein arginine methyltransferase
Echinococcus multilocularis EmuJ_001035900   protein arginine N methyltransferase 8
Homo sapiens ENSG00000111218   protein arginine methyltransferase 8
Leishmania braziliensis LbrM.20.6060   arginine N-methyltransferase-like protein
Leishmania donovani LdBPK_120850.1   arginine N-methyltransferase-like protein
Leishmania infantum LinJ.12.0850   arginine N-methyltransferase-like protein
Leishmania major LmjF.12.1270   arginine N-methyltransferase-like protein
Leishmania mexicana LmxM.12.1270   arginine N-methyltransferase-like protein
Loa Loa (eye worm) LOAG_04505   hypothetical protein
Mus musculus ENSMUSG00000030350   protein arginine N-methyltransferase 8
Mus musculus ENSMUSG00000052429   protein arginine N-methyltransferase 1
Neospora caninum NCLIV_061070   hypothetical protein
Oryza sativa 4346843   Os09g0359800
Plasmodium berghei PBANKA_1018400   protein arginine N-methyltransferase 1, putative
Plasmodium falciparum PF3D7_1426200   protein arginine N-methyltransferase 1
Plasmodium knowlesi PKNH_1332500   protein arginine N-methyltransferase 1, putative
Plasmodium vivax PVX_085215   protein arginine N-methyltransferase 1, putative
Plasmodium yoelii PY05140   probable protein arginine n-methyltransferase
Plasmodium yoelii PY00210   hypothetical protein
Saccharomyces cerevisiae YBR034C   protein-arginine omega-N methyltransferase HMT1
Schistosoma japonicum Sjp_0303070   ko:K00599 prmt1; protein arginine methyltransferase 1 [EC:2.1.1.-], putative
Schistosoma mansoni Smp_029240.1   protein arginine N-methyltransferase 1
Schistosoma mansoni Smp_029240.3   protein arginine N-methyltransferase 1
Schistosoma mansoni Smp_029240.2   protein arginine N-methyltransferase 1
Schmidtea mediterranea mk4.005105.01   Protein arginine methyltransferase 1-like protein
Schmidtea mediterranea mk4.001246.12   Protein arginine methyltransferase 1-like protein
Schmidtea mediterranea mk4.002331.04  
Schmidtea mediterranea mk4.019060.00  
Schmidtea mediterranea mk4.053376.00  
Trypanosoma brucei gambiense Tbg972.1.3210   arginine N-methyltransferase, putative
Trypanosoma brucei Tb927.1.4690   Protein arginine N-methyltransferase 1 catalytic subunit
Trypanosoma congolense TcIL3000_0_59430   arginine N-methyltransferase
Trypanosoma congolense TcIL3000_1_1890   arginine N-methyltransferase, putative
Trypanosoma cruzi TcCLB.506529.50   arginine N-methyltransferase, putative
Trypanosoma cruzi TcCLB.508593.110   arginine N-methyltransferase, putative
Toxoplasma gondii TGME49_219520   histone arginine methyltransferase PRMT1
Theileria parva TP02_0088   arginine N-methyltransferase, putative
Trichomonas vaginalis TVAG_199700   protein arginine N-methyltransferase, putative
Trichomonas vaginalis TVAG_028100   protein arginine N-methyltransferase, putative
Trichomonas vaginalis TVAG_433490   protein arginine N-methyltransferase, putative

Essentiality

LOAG_04505 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.4690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.4690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.4690 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.4690 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y113G7B.17 Caenorhabditis elegans slow growth wormbase
PBANKA_1018400 Plasmodium berghei Slow plasmo
TGME49_219520 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein arginine methyltransferase 8 Compounds References
Emericella nidulans RmtA Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0396 0.4855 0.7374
0.0345 0.3249 0.4161
0.0458 0.2716 0.9465
0.0052 0.488 1
0.0406 1 1
0.0115 0.3498 0.3498
0.0533 0.282 0.5698
0.01 0.3249 0.3249
0.0058 1 0.5
0.0404 1 0.5
0.0344 0.3435 0.4135
0.0089 0.565 0.565
0.0098 1 1
0.0344 0.5304 0.5294
0.0343 0.4302 0.795
0.019 0.326 1
0.0058 1 0.5
0.0058 1 0.5
0.0161 0.4606 0
0.0281 1 1
0.0344 0.4076 0.4149
0.0341 1 1
0.0101 1 0.5
0.0165 0.8277 0.8277
0.012 0.631 0.631
0.0451 0.5198 0.5387
0.0119 0.4389 0.4389
0.01 0.4547 0.4418
0.0338 0.6057 0.688
0.022151 0.446805 0.446805
0.0119 0.4389 0.4389
0.0098 0.5141 0.5141
0.0179 1 1
0.0533 0.282 0.5698
0.0058 1 0.5
0.0099 1 0.5
0.0343 1 1
0.0221 0.2665 1
0.0086 1 0.5
0.0058 1 0.5
0.0116 0.3682 0.3682
0.0184 0.3903 0.5134
0.0071 0.2631 0.2631
0.0058 1 0.5
0.0225 1 1
0.0099 1 0.5
0.046 0.5452 0.547
0.0346 0.41 0.414
0.0527 0.312 0.6033
0.0402 0.484 0.4901
0.0058 0.2729 0.4081
0.0532 0.538 0.6251
0.0475 0.5574 0.5598
0.0115 0.4258 0.6602
0.009 0.3876 0.3876
0.0047 0.2604 0.2693
0.0344 0.5304 0.5294
0.0058 1 0.5
0.0286 0.3558 0.6576
0.0342 0.4271 0.7892
0.011 0.649 0.6437
0.0049 0.2604 0.2693
0.0143094 1 1
0.0211 0.4471 0.482
0.0394 0.4542 0.84
0.0048 0.2604 0.354
0.0527 0.3133 0.6073
0.0058 1 0.5
0.0052 0.3477 0
0.0058 1 0.5
0.0056684 1 1
0.0343 0.4302 0.795
0.0058 1 0.5
0.0249 0.7187 1
0.003 0.9192 1
0.0058 1 0.5
0.0338 0.6057 0.688
0.0533 0.282 0.5698
0.0058 1 0.5
0.0457 0.3571 0.3858
0.0058 1 0.5
0.0374 1 0.5
0.0337 0.3851 0.7119
0.0058 1 0.5
0.041 0.5073 0.5069
0.0094 1 1
0.0058 1 0.5
0.0058 1 0.5
0.0058 1 0.5
0.0173 1 1
0.0058 1 0.5
0.0462 0.2602 0.5353
0.0335 1 0.5
0.0071 0.8958 1
0.0453 0.8441 0.8439
0.0058 1 0.5
0.0185 0.4187 1
0.0047 1 1
0.0058 1 0.5
0.0188 1 0.5
0.0181 1 1
0.0253 1 0.5
0.0056 0.3001 0.3786
0.0476 0.5597 0.559
0.0179 1 1
0.0472 0.5499 0.5499
0.0058 1 0.5
0.0058 1 0.5
0.0058 0.2839 0.2765
0.0319 1 1
0.0225 1 1
0.0128 1 1
0.0058 0.5231 0
0.0458 0.2737 0.9536
0.0402 0.4879 0.4879
0.047 0.2782 0.5384
0.0191 1 1
0.0345 0.3249 0.4161
0.0476 0.5603 0.5603

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LOAG_04505 (Loa Loa (eye worm)), hypothetical protein
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