Detailed view for LOAG_01373

Basic information

TDR Targets ID: 945220
Loa Loa (eye worm), pip kinase 1
Source Database / ID:  KEGG  

pI: 9.5683 | Length (AA): 556 | MW (Da): 62656 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01504   Phosphatidylinositol-4-phosphate 5-Kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016307   phosphatidylinositol phosphate kinase activity  
GO:0046488   phosphatidylinositol metabolic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 129 5ds2 (A) 15 95 33.00 0.68 0.42 0.28066 0.69
105 450 6cn2 (A) 58 426 57.00 0 1 0.924302 0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126948)

Species Accession Gene Product
Arabidopsis thaliana AT2G41210   phosphatidylinositol-4-phosphate 5-kinase 5
Arabidopsis thaliana AT2G26420   phosphatidylinositol-4-phosphate 5-kinase 3
Arabidopsis thaliana AT1G21980   phosphatidylinositol-4-phosphate 5-kinase 1
Arabidopsis thaliana AT1G60890   phosphatidylinositol-4-phosphate 5-kinase 8
Arabidopsis thaliana AT1G77740   phosphatidylinositol-4-phosphate 5-kinase 2
Arabidopsis thaliana AT1G10900   1-phosphatidylinositol-4-phosphate 5-kinase
Arabidopsis thaliana AT3G09920   phosphatidyl inositol monophosphate 5 kinase
Arabidopsis thaliana AT3G07960   phosphatidylinositol-4-phosphate 5-kinase 6
Arabidopsis thaliana AT3G56960   phosphatidylinositol-4-phosphate 5-kinase 4
Brugia malayi Bm1_36090   Pip kinase protein 1
Candida albicans CaO19.10663   Phosphatidylinositol 4-phosphate kinase:
Candida albicans CaO19.3153   Phosphatidylinositol 4-phosphate kinase:
Caenorhabditis elegans CELE_F55A12.2   Protein F55A12.2, isoform D
Caenorhabditis elegans CELE_F55A12.3   Protein PPK-1
Cryptosporidium hominis Chro.80381   phosphatidylinositol-4-phosphate 5-kinase
Cryptosporidium parvum cgd8_3280   phosphatidylinositol-4-phosphate 5-kinase, putative
Dictyostelium discoideum DDB_G0275635   ankyrin repeat-containing protein
Dictyostelium discoideum DDB_G0267588   hypothetical protein
Dictyostelium discoideum DDB_G0292190   hypothetical protein
Dictyostelium discoideum DDB_G0280377   hypothetical protein
Drosophila melanogaster Dmel_CG9985   skittles
Drosophila melanogaster Dmel_CG3682   CG3682 gene product from transcript CG3682-RI
Echinococcus granulosus EgrG_001003000   Phosphatidylinositol 4 phosphate 5 kinase type 1
Entamoeba histolytica EHI_153770   phosphatidylinositol-4-phosphate 5-kinase, putative
Echinococcus multilocularis EmuJ_001003000   Phosphatidylinositol 4 phosphate 5 kinase type 1
Homo sapiens ENSG00000186111   phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
Homo sapiens ENSG00000143398   phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Homo sapiens ENSG00000107242   phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Leishmania braziliensis LbrM.20.2670   phosphatidylinositol-4-phosphate-5-kinase-likep ro tein
Leishmania donovani LdBPK_044320.1   phosphatidylinositol phosphate kinase alpha
Leishmania infantum LinJ.34.4320   phosphatidylinositol-4-phosphate-5-kinase-likep ro tein
Leishmania major LmjF.34.3090   phosphatidylinositol-4-phosphate-5-kinase-likep ro tein
Leishmania mexicana LmxM.33.3090   phosphatidylinositol-4-phosphate-5-kinase-likep ro tein
Loa Loa (eye worm) LOAG_01373   pip kinase 1
Mus musculus ENSMUSG00000024867   phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Mus musculus ENSMUSG00000034902   phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
Mus musculus ENSMUSG00000028126   phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
Neospora caninum NCLIV_031010   Phosphatidylinositol-4-phosphate 5-kinase family protein (EC 2.7.1.68), related
Neospora caninum NCLIV_012830   MORN repeat-containing protein, putative
Oryza sativa 4333833   Os03g0701800
Oryza sativa 4344166   Os07g0658700
Oryza sativa 9267438   Os03g0356582
Oryza sativa 4331188   Os02g0822500
Oryza sativa 4333853   Os03g0705300
Oryza sativa 4332323   Os03g0262000
Oryza sativa 9269201   Os03g0356596
Oryza sativa 9269628   Os11g0145000
Oryza sativa 4351470   Os12g0141100
Plasmodium berghei PBANKA_0203100   phosphatidylinositol-4-phosphate 5-kinase, putative
Plasmodium falciparum PF3D7_0110600   phosphatidylinositol-4-phosphate 5-kinase
Plasmodium knowlesi PKNH_0203300   phosphatidylinositol-4-phosphate 5-kinase, putative
Plasmodium vivax PVX_081270   phosphatidylinositol-4-phosphate 5-kinase, putative
Plasmodium yoelii PY02398   phosphatidylinositol phosphate kinase 6
Saccharomyces cerevisiae YDR208W   1-phosphatidylinositol-4-phosphate 5-kinase
Schistosoma japonicum Sjp_0310030   Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha, putative
Schistosoma japonicum Sjp_0081090   ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative
Schistosoma mansoni Smp_124970   phosphatidylinositol-4-phosphate 5-kinase type I
Schmidtea mediterranea mk4.001221.04  
Schmidtea mediterranea mk4.002264.09  
Schmidtea mediterranea mk4.001964.02  
Schmidtea mediterranea mk4.009148.06  
Schmidtea mediterranea mk4.001800.01  
Schmidtea mediterranea mk4.024447.00  
Schmidtea mediterranea mk4.003911.00  
Schmidtea mediterranea mk4.016357.01  
Trypanosoma brucei gambiense Tbg972.4.1500   phosphatidylinositol 4-phosphate 5-kinase alpha, putative
Trypanosoma brucei Tb927.4.1620   phosphatidylinositol phosphate kinase alpha
Trypanosoma congolense TcIL3000_4_1190   phosphatidylinositol phosphate kinase alpha
Trypanosoma cruzi TcCLB.504057.104   phosphatidylinositol 4-phosphate 5-kinase alpha, putative
Toxoplasma gondii TGME49_292120   membrane occupation and recognition nexus protein MORN2
Toxoplasma gondii TGME49_230490   phosphatidylinositol-4-phosphate 5-kinase
Theileria parva TP02_0200   phosphatidylinositol-4-phosphate 5-kinase, putative
Trichomonas vaginalis TVAG_462290   phosphatidylinositol-4-phosphate 5-kinase type II, putative

Essentiality

LOAG_01373 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.1620 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.1620 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.1620 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.4.1620 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F55A12.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_F55A12.3 Caenorhabditis elegans larval arrest wormbase
CELE_F55A12.3 Caenorhabditis elegans sterile wormbase
CELE_F55A12.2 Caenorhabditis elegans slow growth wormbase
YDR208W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0203100 Plasmodium berghei Essential plasmo
TGME49_292120 Toxoplasma gondii Probably essential sidik
TGME49_230490 Toxoplasma gondii Probably essential sidik
TGME49_292120 Toxoplasma gondii Essentiality uncertain sidik
TGME49_230490 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type I, alpha Compounds References
Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type I, gamma Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LOAG_01373 (Loa Loa (eye worm)), pip kinase 1
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