Detailed view for LOAG_09453

Basic information

TDR Targets ID: 945270
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 8.5697 | Length (AA): 548 | MW (Da): 62576 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07679   Immunoglobulin I-set domain
PF13927   Immunoglobulin domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 266 5k6w (A) 206 415 30.00 0.0000000039 1 0.456279 1.39
134 212 2bk8 (A) 9 92 29.00 0 1 0.473161 -0.7
134 211 4hwu (A) 49 124 24.00 0 0.98 0.468336 -0.82
141 203 3p73 (A) 193 262 44.00 0.029 0.82 0.247563 0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_137570)

Species Accession Gene Product
Brugia malayi Bm1_31415   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_Y102A11A.8   Protein IGCM-4
Echinococcus granulosus EgrG_000842900   fgfr protein
Echinococcus granulosus EgrG_000770900   Immunoglobulin subtype
Echinococcus granulosus EgrG_000816800   fibroblast growth factor receptor 1
Echinococcus multilocularis EmuJ_000770900   Immunoglobulin subtype
Echinococcus multilocularis EmuJ_000816800   fibroblast growth factor receptor 1
Echinococcus multilocularis EmuJ_000842900   fgfr protein
Homo sapiens ENSG00000127418   fibroblast growth factor receptor-like 1
Loa Loa (eye worm) LOAG_09453   hypothetical protein
Mus musculus ENSMUSG00000008090   fibroblast growth factor receptor-like 1
Schistosoma japonicum Sjp_0089370   IPR013151,Immunoglobulin;IPR003598,Immunoglobulin subtype 2;IPR003599,Immunoglobulin subtype;IPR007110,Immunoglobulin-like,domai
Schistosoma japonicum Sjp_0315330   expressed protein
Schistosoma mansoni Smp_052290   hypothetical protein
Schmidtea mediterranea mk4.000319.09  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0058 0.2927 0.3215
0.0104 0.302 0.3104
0.0121 0.4307 0.4307
0.0094 0.3413 0.3413
0.004 0.3126 0.3126
0.014 0.2924 0.2924
0.004 0.2952 0.2941
0.0089 0.2929 0.2929
0.0164 0.4559 0.4559
0.0041 0.5218 0.5218
0.0045 0.5246 0.5892

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_09453 (Loa Loa (eye worm)), hypothetical protein
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