Detailed view for LOAG_05449

Basic information

TDR Targets ID: 945277
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 9.2706 | Length (AA): 462 | MW (Da): 50127 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02135   TAZ zinc finger
PF02172   KIX domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0004402   histone acetyltransferase activity  
GO:0003712   transcription cofactor activity  
GO:0008270   zinc ion binding  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 200 5hou (A) 1002 3434 49.00 0 1 0.851304 -0.12
349 426 4i9o (A) 588 665 65.00 0 1 1.12603 -2.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129174)

Species Accession Gene Product
Arabidopsis thaliana AT1G16710   histone acetyltransferase HAC12
Arabidopsis thaliana AT1G79000   histone acetyltransferase HAC1
Arabidopsis thaliana AT1G55970   histone acetyltransferase of the CBP family 4
Arabidopsis thaliana AT3G12980   histone acetyltransferase HAC5
Arabidopsis thaliana AT1G67220   histone acetyltransferase HAC2
Brugia malayi Bm1_18500   TAZ zinc finger family protein
Caenorhabditis elegans CELE_R10E11.1   Protein CBP-1, isoform B
Drosophila melanogaster Dmel_CG15319   nejire
Echinococcus granulosus EgrG_001080100   CREB binding protein
Echinococcus granulosus EgrG_000850000   CREB binding protein
Echinococcus granulosus EgrG_002071600   CREB binding protein
Echinococcus granulosus EgrG_001080400   CREB binding protein
Echinococcus multilocularis EmuJ_001080100   CREB binding protein
Echinococcus multilocularis EmuJ_000850000   CREB binding protein
Echinococcus multilocularis EmuJ_001080300   CREB binding protein
Echinococcus multilocularis EmuJ_001080000   CREB binding protein
Homo sapiens ENSG00000100393   E1A binding protein p300
Homo sapiens ENSG00000005339   CREB binding protein
Loa Loa (eye worm) LOAG_05448   CBP-B
Loa Loa (eye worm) LOAG_09408   hypothetical protein
Loa Loa (eye worm) LOAG_05449   hypothetical protein
Mus musculus ENSMUSG00000055024   E1A binding protein p300
Mus musculus ENSMUSG00000022521   CREB binding protein
Oryza sativa 4326755   Os01g0246100
Oryza sativa 4328238   Os02g0137500
Oryza sativa 4341999   Os06g0704800
Schistosoma japonicum Sjp_0302930   Protein cbp-1, putative
Schistosoma japonicum Sjp_0009730   CREB-binding protein, putative
Schistosoma japonicum Sjp_0112250   ko:K04498 E1A/CREB-binding protein, putative
Schistosoma japonicum Sjp_0087130   IPR011071,Polysaccharide lyase family 8-like, C-terminal,domain-containing
Schistosoma mansoni Smp_105910   CREB-binding protein 1 (SmCBP1)
Schistosoma mansoni Smp_127010   CREB-binding protein 2
Schmidtea mediterranea mk4.012063.01   Putative creb-binding protein 2
Schmidtea mediterranea mk4.031853.00   Histone acetyltransferase p300
Schmidtea mediterranea mk4.000116.08   Histone acetyltransferase p300
Schmidtea mediterranea mk4.007934.05   Histone acetyltransferase p300
Schmidtea mediterranea mk4.001475.01   Histone acetyltransferase p300
Schmidtea mediterranea mk4.006098.06  
Schmidtea mediterranea mk4.014980.02   Histone acetyltransferase p300
Schmidtea mediterranea mk4.001475.00  
Schmidtea mediterranea mk4.000116.10  
Schmidtea mediterranea mk4.006098.05  
Schmidtea mediterranea mk4.018267.00  
Schmidtea mediterranea mk4.014980.01  
Schmidtea mediterranea mk4.009011.01  
Schmidtea mediterranea mk4.007662.01   Histone acetyltransferase p300
Schmidtea mediterranea mk4.015554.01   Histone acetyltransferase p300
Schmidtea mediterranea mk4.006098.04  
Schmidtea mediterranea mk4.040346.01  
Schmidtea mediterranea mk4.012063.00  
Schmidtea mediterranea mk4.006098.03   Histone acetyltransferase p300
Schmidtea mediterranea mk4.026864.00  

Essentiality

LOAG_05449 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R10E11.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_R10E11.1 Caenorhabditis elegans slow growth wormbase
CELE_R10E11.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens CREB binding protein Compounds References
Homo sapiens E1A binding protein p300 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0353 0.3654 0
0.0046 0.3846 0.4186
0.0257 0.3579 0.5256
0.0397 0.2834 0.6693
0.021 0.358 0.5357
0.0106 0.3104 0.3104
0.0303 0.3855 0
0.0286 0.3849 0
0.0472 0.4254 0.5169
0.0106 0.3066 0
0.0153 0.3658 0.3948
0.0057 0.2602 0.3381
0.0046 0.3813 0.5923
0.0096 0.3654 0
0.0407 0.4624 0.6698
0.0103 0.2965 0.2965
0.0534 0.2761 0.0934
0.0057 0.4035 0.6146
0.0130559 0.265083 0.265083
0.0057 0.3654 0.3235
0.046 0.3755 0.3989
0.0513 0.3986 0.4619
0.0209 0.3872 0.2426
0.0048 0.3895 0.6007
0.0423 0.4437 0.65
0.0396 0.4638 0.671
0.0396 0.4638 0.671
0.0098 0.3303 0.2537
0.0052 0.3654 0.4261
0.04 0.4638 0.671
0.0453 0.4278 0.5172
0.0098 0.4194 0.6301
0.01 0.4143 0.6251
0.0057 0.272 0.4068
0.0145 0.3571 0.5587
0.0102 0.3579 0
0.0047 0.3886 0.5997
0.0055 0.2602 0.3381
0.0095 0.4194 0.6301
0.0288 0.4118 0.6227
0.0095 0.3229 0.3248
0.0152 0.3559 0
0.0202 0.3579 0
0.020293 0.359118 0.276225
0.0323 0.4531 0.6503
0.0523 0.3409 0.0957
0.0052 0.3654 0.4261
0.0109 0.4528 0.6572
0.0164 0.3654 0
0.0152 0.3559 0
0.037 0.38 0.4943
0.0115 0.2896 0.2896
0.0092 0.3579 0
0.0155 0.3558 0
0.0057 0.343 0.343
0.0046 0.2602 0.3381
0.0313077 0.46558 0.673715
0.0207 0.2651 0.4957
0.021 0.358 0.5357
0.0057 0.2602 0.3381
0.0253 0.3562 0.6684
0.0103 0.4194 0.6301
0.0429 0.4194 0.6301
0.0418 0.3654 0
0.0142 0.2733 0
0.0056 0.2928 0.3242
0.0048 0.2573 0.2573
0.0428 0.3654 0
0.0249 0.3513 0.6683
0.0096 0.3654 0.5435
0.0149 0.3665 0.3663
0.0051 0.2702 0.2672
0.0057 0.2602 0.3381
0.0057 0.3654 0.4952
0.0155 0.3558 0
0.0057 0.368 0.4952
0.0394 0.2857 0.6719
0.047 0.402 0.4931
0.0096 0.4144 0.6252
0.0054 0.3703 0.3507
0.029 0.3336 0.6501
0.0057 0.2602 0.3381
0.0201 0.3579 0
0.0145 0.3581 0.5613

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LOAG_05449 (Loa Loa (eye worm)), hypothetical protein
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