Detailed view for LOAG_05957

Basic information

TDR Targets ID: 945366
Loa Loa (eye worm), AMP-binding enzyme family protein

Source Database / ID:  KEGG  

pI: 8.8902 | Length (AA): 633 | MW (Da): 72421 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00501   AMP-binding enzyme
PF13193   AMP-binding enzyme C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
41 608 5es5 (A) 170 678 21.00 0 1 1.01631 0.5
74 612 4wv3 (A) 4 516 23.00 0 1 1.0735 -0.13
93 611 3r44 (A) 19 496 28.00 0 1 1.04491 0.13
508 608 3lax (A) 325 431 12.00 0 0.31 0.335158 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127399)

Species Accession Gene Product
Brugia malayi Bm1_33165   AMP-binding enzyme family protein
Candida albicans CaO19.11137   similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase
Candida albicans CaO19.3653   similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase
Caenorhabditis elegans CELE_D1009.1   Protein ACS-22, isoform B
Caenorhabditis elegans CELE_F28D1.9   Protein ACS-20
Drosophila melanogaster Dmel_CG44252   CG44252 gene product from transcript CG44252-RE
Drosophila melanogaster Dmel_CG7400   Fatty acid (long chain) transport protein
Drosophila melanogaster Dmel_CG3394   CG3394 gene product from transcript CG3394-RA
Echinococcus granulosus EgrG_000080700   long chain fatty acid transport protein 4
Echinococcus multilocularis EmuJ_000080700   long chain fatty acid transport protein 4
Homo sapiens ENSG00000140284   solute carrier family 27 (fatty acid transporter), member 2
Homo sapiens ENSG00000130304   solute carrier family 27 (fatty acid transporter), member 1
Homo sapiens ENSG00000167114   solute carrier family 27 (fatty acid transporter), member 4
Homo sapiens ENSG00000113396   solute carrier family 27 (fatty acid transporter), member 6
Leishmania braziliensis LbrM.24.1850   fatty acid transporter protein-like protein
Leishmania donovani LdBPK_241850.1   fatty acid transporter protein-like protein
Leishmania infantum LinJ.24.1850   fatty acid transporter protein-like protein
Leishmania major LmjF.24.1780   fatty acid transporter protein-like protein
Leishmania mexicana LmxM.24.1780   fatty acid transporter protein-like protein
Loa Loa (eye worm) LOAG_05957   AMP-binding enzyme family protein
Mycobacterium leprae ML1346   possible long-chain acyl-CoA synthase
Mus musculus ENSMUSG00000031808   solute carrier family 27 (fatty acid transporter), member 1
Mus musculus ENSMUSG00000059316   solute carrier family 27 (fatty acid transporter), member 4
Mus musculus ENSMUSG00000024600   solute carrier family 27 (fatty acid transporter), member 6
Mus musculus 26458   solute carrier family 27 (fatty acid transporter), member 2
Mycobacterium tuberculosis Rv1206   Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mycobacterium ulcerans MUL_0957   long-chain-acyl-CoA synthetase
Saccharomyces cerevisiae YBR041W   long-chain fatty acid transporter FAT1
Schistosoma japonicum Sjp_0312340   Long-chain fatty acid transport protein 4, putative
Schistosoma japonicum Sjp_0005620   ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative
Schistosoma mansoni Smp_143830   FFA transport protein
Schmidtea mediterranea mk4.001150.05  
Schmidtea mediterranea mk4.001150.07  
Trypanosoma cruzi TcCLB.506799.10   fatty acid transporter protein-like, putative
Trypanosoma cruzi TcCLB.511907.110   fatty acid transporter protein-like, putative

Essentiality

LOAG_05957 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F28D1.9 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 27 (fatty acid transporter), member 2 Compounds References
Mus musculus solute carrier family 27 (fatty acid transporter), member 1 Compounds References
Homo sapiens solute carrier family 27 (fatty acid transporter), member 1 Compounds References
Homo sapiens solute carrier family 27 (fatty acid transporter), member 4 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Photinus pyralis Luciferin 4-monooxygenase 550 aa 23.3% 489 aa Compounds References
Yersinia pestis AMP-binding enzyme family protein 525 aa 18.4% 527 aa Compounds References
Photuris pennsylvanica Luciferase 552 aa 24.9% 531 aa Compounds References
Luciola lateralis Luciferase 548 aa 23.9% 506 aa Compounds References
Photuris pennsylvanica Luciferin 4-monooxygenase 545 aa 24.5% 497 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0231 0.642 0.642
0.1581 0.636 1
0.038 0.687 1
0.1853 0.7221 1
0.0804 0.4198 0.8443
0.2132 1 1
0.0898 0.2512 0.5763
0.115 0.3241 0.8981
0.0812 0.3221 0.6476
0.1581 0.636 1
0.0189 0.5677 0.5663
0.1806 1 1
0.1789 1 1
0.0865 0.4901 1
0.3127 0.8986 1
0.0851 0.8825 1
0.0231 1 1
0.1358 0.779 1
0.1312 1 1
0.0412 0.2754 0.5586
0.0716 0.3055 0.7827
0.1292 0.6331 1
0.0389 0.4638 0.6065
0.0218 0.8975 1
0.0231 1 1
0.008 0.2859 0.2859
0.0199 0.2606 0.2601
0.0461 1 1
0.09 0.3472 0.7216
0.0825 0.3464 1
0.0480743 1 1
0.0405 0.5689 0.5689
0.1433 0.67 1
0.0231 1 1
0.0231 1 1
0.0219 0.3831 0.437
0.0223 0.8695 1
0.0198 0.4382 0.4382
0.0193 0.2636 0.2636
0.0231 1 1
0.1165 1 1
0.0231 1 1
0.295 0.7762 1
0.1902 0.6392 1
0.1135 0.3685 0.8942
0.0593 0.7352 1
0.0772 0.9937 1
0.09 0.2532 0.5784
0.2646 1 1
0.0767 0.5615 1
0.1872 0.4706 1
0.0412 0.2754 0.5586
0.122874 0.761394 1
0.1311 1 1
0.0231 1 1
0.0812 0.3141 0.6498
0.1617 1 1
0.1016 0.2683 0.7884
0.0477 0.279 0.5158
0.0231 1 1
0.1241 0.3216 0.6364
0.1089 1 1
0.3065 1 1
0.3095 1 1
0.0231 1 1
0.0231 1 1
0.4075 1 1
0.0231 1 1
0.1316 0.7414 1
0.0189 1 1
0.0224 0.419 0.479
0.2747 0.9503 1
0.071 0.2696 0.9969
0.0392 0.5357 1
0.0995 0.3505 0.7778
0.2391 0.3976 1
0.2615 1 1
0.0241 0.2784 0.7553
0.0955 1 1
0.0195 0.2855 0.6465
0.0381 0.4298 0.6656
0.064 0.3735 1
0.1096 1 1
0.0219 0.2937 1
0.0963 0.3972 1
0.0231 1 1
0.0241 0.2784 0.7553
0.0315 0.2715 0.3397
0.2043 0.5327 1
0.0906 0.2708 0.5539
0.189 0.5711 1
0.1438 0.4797 1
0.0815 0.4116 1
0.0377 0.4656 0.8076
0.077 0.4509 1
0.0549 0.3138 1
0.0195 0.2971 1
0.1159 0.6528 0.8592
0.3127 0.8986 1
0.1714 0.2899 0.75
0.0809 0.4721 0.8477
0.1217 0.3019 1
0.1757 0.3743 0.3743
0.079 0.4704 1
0.089 0.315 0.9684
0.0875 1 1
0.3081 1 1
0.0412 0.2754 0.5586
0.2825 1 1
0.0549 0.3112 0.7727
0.0812 0.3141 0.6498
0.081 0.4119 1
0.0231 1 1
0.1332 0.7425 1
0.0663 0.3993 1
0.1073 0.6148 1
0.0231 1 1
0.0384 0.4919 1
0.2573 1 1
0.0572 1 1
0.0231 1 1
0.0372 0.374 0.8784
0.1553 0.5984 1
0.0158 0.349 0.6549
0.0188 0.4996 0.4996
0.0097 1 1
0.1034 0.5966 1
0.2521 0.6148 1
0.0869 1 1
0.0874 0.5059 1
0.0977 0.2692 0.5893
0.1354 0.271 0.6981
0.0796 0.2781 0.6095
0.1755 0.9398 1
0.0241 0.2784 0.7553
0.0638 0.3011 0.5157
0.08 0.3635 0.8499
0.0231 1 1
0.0963 0.3972 1
0.2245 1 1
0.0836 1 1
0.0872 0.617 0.646
0.0977 0.2692 0.5893
0.2085 0.7204 1
0.0189 1 1
0.0231 0.397 0.3951
0.0231 1 1
0.1977 0.5927 1
0.0517 1 1
0.0195 0.5159 0.6862
0.0382 0.5139 1
0.0402 0.844 0.848
0.0231 1 1
0.0885953 1 1
0.0873 0.3744 0.9548
0.0231 1 1
0.134 0.2642 0.7938
0.1813 0.266 0.9134
0.1252 0.807 1
0.0716 0.3333 0.7502
0.134 1 1
0.0635 0.2837 0.7636
0.081 0.4119 1
0.0231 1 1
0.134 1 1
0.0231 0.2916 0.2916
0.263 1 1
0.1794 0.2681 0.7858
0.1077 0.9435 1
0.116 0.4476 0.8462
0.0231 1 1
0.1316 0.8119 1
0.081 0.4119 1
0.0869 0.3297 1
0.0097 1 1
0.0806 0.3821 0.8603
0.1271 1 1
0.0194 0.2595 0.392
0.1336 0.2714 0.8189
0.0156 0.318 0.6425
0.0185 0.464 0.7186
0.0185 0.4327 1
0.189 0.5711 1
0.0709 1 1
0.3186 1 1
0.0375 0.4238 0.7327
0.1304 1 1
0.0381 0.4298 0.6656
0.0187 0.4648 0.7662
0.0201 0.3878 0.3859
0.0896 0.2553 0.7231
0.0186 0.5231 0.6714
0.0873 0.2856 1
0.0387 0.767 0.767
0.0967 0.2517 1
0.189 0.5711 1
0.0375 1 1
0.0919 0.2987 0.7202
0.0438 1 1
0.1581 0.636 1
0.1134 0.7993 1
0.1964 0.5885 1
0.2924 1 1
0.0231 1 1
0.119 1 1
0.0814 0.3868 0.8642
0.1061 0.3504 1
0.0818 0.2645 0.6488
0.0902 0.2554 0.5865
0.0231 0.5656 0.5656
0.1261 1 1
0.1665 1 1
0.0097 0.8534 0.8534
0.0231 0.7069 0.7898
0.1166 0.4492 0.8581
0.0248 0.2926 1
0.0097 1 1
0.1762 0.6715 1
0.022 1 1
0.0807 0.3216 0.6494
0.1118 0.7903 1
0.0462 1 1
0.0192 0.3882 0.3882
0.102 1 1
0.0911 0.3538 0.7322
0.1757 0.3743 0.3743
0.0377 0.4648 1
0.0231 1 1
0.0231 0.9616 1
0.0214 0.3241 0.6787
0.0398 0.4834 0.7046
0.3033 1 1
0.1316 0.8119 1
0.1776 0.5829 1
0.2561 1 1
0.1329 1 1
0.1138 0.6867 1
0.1358 0.8241 1
0.009 0.3935 1
0.1688 0.3323 0.8476
0.0187 0.4648 0.7662
0.1071 1 1
0.0716 0.3333 0.7502
0.0885 0.7112 0.8749
0.1302 1 1
0.0231 1 1
0.0978 1 1
0.1909 0.3233 0.3233
0.1309 1 1
0.1553 0.5984 1
0.2211 1 1
0.0636 1 1
0.0469 0.2738 0.3692
0.0231 0.2533 0.6878
0.0231 1 1
0.1149 1 1
0.0231 1 1
0.3066 0.6082 1
0.3227 0.2697 1
0.1247 0.2525 0.6419
0.0078651 1 1
0.3054 0.3334 1
0.1185 0.974 1
0.0231 1 1
0.1071 1 1
0.0206 0.6898 0.6886
0.0801 0.2714 0.625
0.0721 0.4194 1
0.1791 0.2661 0.7792
0.0097 1 1
0.0549 0.5091 0.5081
0.0375 0.7725 1
0.0873 0.2856 1
0.0398 0.4636 0.8323
0.2561 1 1
0.1814 0.2648 0.912
0.0469 1 1
0.0909 0.3695 1
0.1814 0.2648 0.912
0.189 0.5711 1
0.0189 0.3725 0.3718
0.1791 0.557 1
0.0772 1 1
0.0221 0.7182 0.7171
0.2706 1 1
0.1883 0.6223 1
0.1191 0.5661 1
0.0391 1 1
0.081 0.4119 1
0.2797 1 1
0.0224 0.7067 0.7066
0.0231 1 1
0.0479 0.5102 0.7929
0.0231 1 1
0.064 1 1
0.0464 0.9684 1
0.2856 0.8697 1
0.0231 1 1
0.0205 1 1
0.0885953 1 1
0.09 0.3713 0.7265
0.0963 0.3972 1
0.1701 0.3357 0.8579
0.1159 1 1
0.0187 0.3517 0.4017
0.0231 0.7513 0.7513
0.2441 0.9544 1
0.1278 1 1
0.0231 0.615 0.615
0.3033 0.833 1
0.0377 0.4648 1
0.0634 0.3377 0.5023
0.0391 0.3902 1
0.3051 1 1
0.0638 1 1
0.0231 1 1
0.039 0.3645 0.3991
0.1944 0.6866 1
0.0902 0.359 0.5765
0.1753 0.5329 1
0.314 0.8794 1
0.1006 0.4081 1
0.0188 1 1
0.0186 0.6178 0.6178
0.0477 0.4805 0.7686
0.3405 1 1
0.0381 0.6203 0.6203
0.293 0.775 1
0.0909 0.3695 1
0.1086 0.307 0.8541
0.02 0.2564 0.2564
0.0392 0.4698 0.7535
0.3107 0.8816 1
0.1343 0.7963 1
0.2797 1 1
0.2513 1 1
0.0382 0.4457 0.7792
0.0186 0.2667 0.6888
0.142 0.6195 1
0.0909 0.3695 1
0.0451 0.5037 1
0.0838 0.5696 1
0.1083 0.3009 0.6772
0.0401 0.3462 0.665
0.0205 0.3887 0.803
0.081 0.4119 1
0.039 0.3322 0.4031
0.174 0.2593 0.8829
0.071 0.27 0.997
0.3343 1 1
0.0462 0.2841 1
0.1335 0.3447 0.8208
0.1324 0.3645 0.8179
0.1153 0.4474 0.8449
0.1036 1 1
0.0241 0.2784 0.7553
0.2646 1 1
0.0955 0.4999 1
0.0231 1 1
0.0088 0.2627 0.2509
0.1306 1 1
0.2817 1 1
0.0635 0.2837 0.7636
0.0915 0.2813 1
0.2617 1 1
0.1909 0.3233 0.3233
0.0205 0.3887 0.803
0.3033 1 1
0.0654 0.3166 0.9162
0.0231 1 1
0.1601 0.3169 0.812
0.1753 0.5329 1
0.0187 0.4648 0.7662
0.0239 0.2876 0.7025
0.1342 0.8008 1
0.08 0.4177 0.846
0.1789 0.6553 1
0.1077 0.3008 0.8403
0.0726598 1 1
0.0890652 1 1
0.1581 0.636 1
0.0357 0.6292 1
0.0313 0.7174 0.7158
0.1872 0.4706 1
0.1132 0.3157 0.766
0.1829 1 1
0.1325 0.3422 0.8354
0.0219 0.3003 0.4624
0.0231 1 1
0.025 1 1
0.2705 1 1
0.0807 0.3205 0.6476
0.1132 0.3157 0.766
0.1602 0.7524 1
0.2854 1 1
0.1249 1 1
0.2127 0.8707 1
0.0379 0.5225 0.5225
0.1252 0.807 1
0.0471 0.5561 1
0.0194 0.3939 0.3939
0.1233 1 1
0.1181 0.5287 0.8724
0.0301 1 1
0.3054 0.3334 1
0.1714 0.2899 0.75
0.0187 0.6112 0.8297
0.0222 1 1
0.1247 0.2525 0.7638
0.1057 0.344 0.8346
0.0195 0.268 1
0.0412 0.2754 0.5586
0.1166 0.4492 0.8581
0.1332 0.7425 1
0.025101 1 1
0.1439 0.2862 0.7342
0.288 1 1
0.1757 0.3743 0.3743
0.0193 0.2636 0.2636
0.1581 0.636 1
0.3227 0.2697 1
0.0231 1 1
0.1578 1 1
0.1042 0.8527 1
0.0412 0.2754 0.5586
0.0638 0.399 1
0.1368 0.3145 1
0.1355 0.8178 1
0.2599 1 1
0.0231 1 1
0.0402 0.5566 0.5566
0.3066 0.6082 1
0.0386 0.5134 1
0.0199 0.2929 1
0.1132 0.3157 0.766
0.1165 0.2837 0.6021
0.0186 0.421 0.6328
0.1033 0.2512 1
0.424572 1 1
0.3008 0.7161 1
0.1986 0.5592 1
0.1132 0.3157 0.766
0.1021 1 1
0.0313 0.3125 1
0.0721 0.4194 1
0.1936 0.6288 1
0.0191 0.2677 0.9138
0.1356 0.8118 1
0.0276 0.2661 1
0.02528 1 1
0.1309 1 1
0.2496 1 1
0.0397 0.8478 0.8472
0.1917 0.4528 0.4528
0.1294 1 1
0.1042 0.8527 1
0.1074 0.6117 1
0.0375 0.4238 0.7327
0.2854 1 1
0.1753 0.5329 1
0.2174 1 1
0.0381 0.4298 0.6656
0.1753 0.5329 1
0.1427 0.8467 1
0.0197 0.5169 0.6063
0.0896 0.3356 0.5684
0.2581 1 1
0.1523 0.9048 1
0.1068 0.7591 1
0.1463 0.2871 1
0.0231 1 1
0.189 0.5198 1
0.1155 0.2781 1
0.1829 1 1
0.113 1 1
0.1814 0.2648 0.912
0.088 0.3091 0.5667
0.1341 0.2635 0.7903
0.0202 0.84 1
0.0399 0.7622 0.7622
0.0412 0.2754 0.5586
0.1966 0.6387 1
0.0231 1 1
0.0187 1 1
0.1195 1 1
0.2954 1 1
0.3051 1 1
0.0021 0.2636 0.2636
0.0231 0.9692 0.9692
0.0231 1 1
0.1175 0.768 1
0.0561 0.4782 0.8987
0.0798 0.571 1
0.0218 0.6403 0.639
0.108628 1 1
0.0898 0.4854 0.9769
0.0187 1 1
0.0231 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_05957 (Loa Loa (eye worm)), AMP-binding enzyme family protein
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