Detailed view for LOAG_08413

Basic information

TDR Targets ID: 945699
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.6141 | Length (AA): 706 | MW (Da): 80946 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02225   PA domain
PF04253   Transferrin receptor-like dimerisation domain
PF04389   Peptidase family M28

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 699 3fed (A) 52 736 36.00 0 1 1.43718 -1
1 700 5ely (A) 62 747 33.00 0 1 1.3996 -0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128101)

Species Accession Gene Product
Arabidopsis thaliana AT5G19740   peptidase M28 family protein
Candida albicans CaO19.7106   similar to transferrin receptor
Candida albicans CaO19_7106   hypothetical protein
Caenorhabditis elegans CELE_R57.1   Protein R57.1, isoform B
Echinococcus multilocularis EmuJ_000908900   n acetylated alpha linked acidic dipeptidase 2
Homo sapiens ENSG00000077616   N-acetylated alpha-linked acidic dipeptidase 2
Homo sapiens 219595   folate hydrolase 1B
Homo sapiens ENSG00000086205   folate hydrolase (prostate-specific membrane antigen) 1
Loa Loa (eye worm) LOAG_08413   hypothetical protein
Loa Loa (eye worm) LOAG_11747   hypothetical protein
Loa Loa (eye worm) LOAG_13324   hypothetical protein
Mus musculus ENSMUSG00000043943   N-acetylated alpha-linked acidic dipeptidase 2
Mus musculus ENSMUSG00000001773   folate hydrolase 1
Oryza sativa 4326550   Os01g0743300
Oryza sativa 4327207   Os01g0740500
Saccharomyces cerevisiae YJR126C   Vps70p
Schistosoma japonicum Sjp_0085790   ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative
Schistosoma mansoni Smp_135510   NAALADASE L peptidase (M28 family)
Schmidtea mediterranea mk4.087005.00  
Schmidtea mediterranea mk4.023574.00   N-acetylated-alpha-linked acidic dipeptidase-like protein
Schmidtea mediterranea mk4.010512.01   N-acetylated-alpha-linked acidic dipeptidase-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens folate hydrolase (prostate-specific membrane antigen) 1 Compounds References
Rattus norvegicus Glutamate carboxypeptidase II Compounds References
Homo sapiens N-acetylated alpha-linked acidic dipeptidase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0167 0.4683 0.4683
0.01 0.6924 0.6924
0.0567 0.2961 0.2961
0.0732 0.4184 0.4212
0.0429 0.6337 1
0.1378 0.463 0.463
0.0784 0.5702 1
0.0334 0.3173 1
0.4999 0.3269 0.6873
0.0692 0.9215 1
0.0582 0.5175 0.5175
0.0318 0.3394 0.3391
0.1161 0.5336 1
0.0387 0.2888 0.4006
0.0153 0.3117 0.3117
0.0279 0.329 0.8998
0.0442 0.2993 0.6783
0.0569 0.304 0.3039
0.0167 0.5157 0.5157
0.0284 0.9653 1
0.0167 0.5902 0.586
0.0273 0.3848 0.294
0.0167 0.3199 0.3052
0.056 0.5839 1
0.0154 0.2796 0.3223
0.0417 0.6176 0.6449
0.0666 0.8723 0.9938
0.0328 0.5296 1
0.1337 0.5263 1
0.0469 0.5082 0.5153
0.405 0.7151 1
0.220812 1 1
0.0167 0.3157 0.3157
0.0279 0.3353 1
0.0298 0.3034 1
0.0167 0.5962 1
0.0146 0.3212 0.4444
0.1054 0.2995 0.9535
0.0475 0.375 1
0.0583 0.3075 0.3075
0.0807 0.2836 0.2836
0.0293 0.3531 0.6668
0.018 0.9927 0.9927
0.0487 0.2883 0.2883
0.0596 0.5989 1
0.1337 0.5263 1
0.0197 0.7409 1
0.0922 0.2507 0.2803
0.1123 0.2813 0.4241
0.0417 0.5144 1
0.0418 0.832 0.9508
0.0853 0.2502 1
0.0375 0.3977 0.3956
0.0424 0.2942 1
0.058 0.594 0.6496
0.0242 0.4165 0.4876
0.1161 0.5336 1
0.0281 0.7663 1
0.0269 0.2672 0.7159
0.0443 0.3811 0.3801
0.0948 0.4035 1
0.0167 0.9073 0.9073
0.0853 0.2502 1
0.2414 0.4773 0.5177
0.0167 0.4065 0.4389
0.0282 0.5943 1
0.0419 0.2871 0.2869
0.0167 0.3378 0.5881
0.0167 0.5753 1
0.1854 0.6635 0.6635
0.0142 0.2796 0.3223
0.0167 0.5654 0.4926
0.0161 0.5025 0.5025
0.0135 0.7626 1
0.0167 0.3898 0.3892
0.0974 0.5991 0.9441
0.0567 0.2961 0.2961
0.0167 0.4007 1
0.4293 0.2917 0.2917
0.0167 0.5041 0.5041
0.0167 0.5592 0.6116
0.0447 0.6052 0.9081
0.0313 0.3147 1
0.1123 0.2813 0.4241
0.2571 0.4724 1
0.0442 0.2993 0.6783
0.4999 0.3269 0.6873
0.0167 0.3991 1
0.0712 0.2905 0.2905
0.0235 0.2859 1
0.0307 0.3323 0.6078
0.0701 0.9347 0.9347
0.0276 0.9598 1
0.0279 0.329 0.8998
0.0233 0.356 0.3544
0.0475 0.537 1
0.0464 0.4567 1
0.0725 0.8779 1
0.0457 0.4549 1
0.0293 0.2957 0.7853
0.029 0.2637 1
0.0167 0.4832 0.4832
0.1854 0.6635 0.6635
0.0505 0.4831 0.5282
0.0276 0.3124 0.5722
0.0425 0.5157 1
0.0302 0.3032 1
0.1123 0.2813 0.4241
0.0553 0.3179 0.3032
0.0556 0.3743 1
0.0719 0.2631 1
0.0473 0.5585 1
0.0417 0.6176 0.6449
0.0136 0.4666 0.4666
0.0922 0.2507 0.2803
0.0274 0.2659 1
0.0205 0.4749 0.5759
0.5251 0.2795 0.6745
0.0525 0.9137 1
0.0137 0.8544 0.8544
0.2767 0.257 1
0.0225 0.644 0.644
0.0167 0.292 0.8201
0.0417 0.4781 1
0.0486 0.869 1
0.5273 0.3677 0.708
0.1337 0.5263 1
0.0275 0.411 0.411
0.041 0.5341 1
0.0167 0.9073 0.9073
0.045 0.4215 0.4215
0.0318 0.3114 1
0.5251 0.2795 0.6745
0.0276 0.2615 0.2651
0.0807 0.2836 0.2836
0.0385 0.3517 0.2764
0.0167 0.337 0.5933
0.0163 0.5309 0.573
0.0462 0.5463 1
0.0167 0.6251 0.6251
0.014 0.3654 0.4002
0.0142 0.309 0.9245
0.0279 0.3353 1
0.5251 0.2795 0.6745
0.5251 0.2795 0.6745
0.058 0.5942 0.6498
0.1511 0.2784 0.3816
0.027 0.3227 1
0.0409 0.9552 1
0.1854 0.6635 0.6635
0.0148 0.5 0.5
0.0464 0.5504 1
0.0387 0.2888 0.4006
0.1337 0.5263 1
0.2767 0.257 1
0.0469 0.5082 0.5153
0.0279 0.329 0.8998
0.0471 0.4501 1
0.0385 0.3517 0.2764
0.014 0.3654 0.4002
0.0447 0.56 1
0.0139 0.8165 0.8165
0.045 0.4215 0.4215
0.0379 0.3145 1
0.0358 0.3073 0.3761
0.0974 0.5991 0.9441
0.0167 0.4422 1
0.5251 0.2795 0.6745
0.014 0.4625 0.4669
0.0468 0.2503 1
0.073 0.4576 1
0.0138 0.2595 0.331
0.0167 0.5894 0.586
0.0167 0.374 1
0.0275 0.4652 0.4652
0.0807 0.2836 0.2836
0.0365 0.4563 1
0.0697 0.252 1
0.0443 0.3811 0.3801
0.0167 0.4144 1
0.5251 0.2795 0.6745
0.0135 0.3715 0.401
0.0387 0.2888 0.4006
0.0172 0.2618 0.2618
0.0233 0.356 0.3544
0.0167 0.496 1
0.039075 1 1
0.0429 0.4597 0.4595
0.0167 0.2796 0.3223
0.346 0.4661 1
0.119213 0.29421 0.443469
0.0153 0.661 1
0.0167 0.4359 0.4359
0.0313 0.7561 1
0.0167 0.3682 0.8436
0.0826 0.9894 1
0.0167 0.5455 0.5455
0.0276 0.9598 1
0.0418 0.832 0.9508
0.0143 0.6284 1
0.0811 0.6761 1
0.0569 0.304 0.3039
0.2767 0.2571 1
0.0442 0.2993 0.6783
0.0365 0.4563 1
0.0279 0.329 0.8998
0.0283 0.8836 0.8836
0.1732 0.6238 0.6224
0.1337 0.5263 1
0.0136 0.26 0.8561
0.0267 0.5372 0.5266
0.0164 0.4836 1
0.1337 0.5263 1
0.0134 0.2703 0.267
0.0167 0.9073 0.9073
0.0138 0.395 0.395
0.0582 0.5175 0.5175
0.0207 0.6634 0.6634
0.0273 0.4 0.4
0.0053 0.2835 0.6058
0.041 0.4055 1
0.0118 0.3782 0.3782
0.067 0.276 0.9464
0.2282 0.2673 0.2673
0.0242 0.4165 0.4876
0.0771 0.3487 0.76
0.9164 0.2529 0.3398
0.0167 0.4683 0.4683
0.0182 0.3513 0.3513
0.0282 0.36 1
0.0608 0.4599 0
0.045 0.2824 0.2824
0.0525 0.9137 1
0.0417 0.6176 0.6449
0.0692 0.9215 1
0.0277 0.2687 0.9682
0.1337 0.5263 1
0.0719 0.2631 1
0.0269 0.2636 0.9377
0.0138 0.2903 0.2765
0.0273 0.3848 0.294
0.0167 0.6277 0.7216
0.5251 0.2795 0.6745
0.2571 0.4724 1
0.0249 0.436 0.436
0.0087 0.4192 0.7007
0.4623 0.2796 0.6746
0.0167 0.6159 0.4594
0.0193 0.6314 1
0.0401 0.5169 1
0.0922 0.2507 0.2803
0.0665 0.3042 1
0.0599 0.313 0.313
0.0433 0.3735 1
0.0294 0.2905 0.836
0.0307 0.2939 1
0.0135 0.8076 1
0.0167 0.342 0.5225
0.0313 0.7561 1
0.1378 0.463 0.463
0.7765 0.2866 0.355
0.0417 0.6176 0.6449
0.0167 0.6583 0.6583
0.0826 0.9894 1
0.0336 0.2559 0.1998
0.0274 0.276 1
0.0269 0.2672 0.7159
0.0368 0.2873 0.2873
0.0535 0.5687 0.8847
0.1378 0.463 0.463
0.0144 0.2968 0.2961
0.0274 0.276 1
0.1854 0.6635 0.6635
0.0167 0.3264 0.3707
0.0447 0.56 1
0.027 0.3227 1
0.0367 0.3745 0.4005
0.0583 0.3075 0.3075
0.0273 0.3848 0.294
0.0242 0.4165 0.4876
0.0807 0.2836 0.2836
0.0148 0.8766 1
0.0228 1 1
0.0293 0.3533 0.6668
0.0417 0.6176 0.6449
0.0657 0.4391 1
0.0294 0.918 0.918
0.06 0.7872 1
0.0154 0.2796 0.3223
0.0451 0.3054 0.7195
0.0161 0.5025 0.5025
0.0158 0.6894 1
0.0693 0.7005 1
0.0411 0.3718 0.6188
0.0167 0.2909 0.2909
0.0154 0.2796 0.3223
0.0167 0.2795 0.2777
0.0193 0.2708 1
0.0267 0.2613 1
0.0614 0.3034 0.5088
0.5592 0.5649 0.708
0.0218 0.2606 1
0.0205 0.4749 0.5759
0.5251 0.2795 0.6745
0.4223 0.3716 0.3716
0.0329 0.4035 0.7358
0.0284 0.337 0.4691
0.0318 0.3394 0.3391
0.0306 0.7243 1
0.0141 0.8343 0.8302

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08413 (Loa Loa (eye worm)), hypothetical protein
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