Detailed view for LOAG_15212

Basic information

TDR Targets ID: 945711
Loa Loa (eye worm), hypothetical protein

Source Database / ID:  KEGG  

pI: 9.9815 | Length (AA): 71 | MW (Da): 7721 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01530   Zinc finger, C2HC type

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0003700   transcription factor activity  
GO:0008270   zinc ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 69 2cs8 (A) 37 100 38.00 0 0.68 1.25959 0.83
31 63 1pxe (A) 17 49 52.00 0 0.68 1.02889 0.13
31 71 2cs8 (A) 9 49 39.00 0 0.72 1.07276 -0.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129783)

Species Accession Gene Product
Brugia malayi Bm1_11340   C2-HC type zinc finger protein C.e-MyT1
Caenorhabditis elegans CELE_F52F12.6   Protein ZTF-11, isoform A
Drosophila melanogaster Dmel_CG43689   CG43689 gene product from transcript CG43689-RH
Echinococcus granulosus EgrG_000598400   suppression of tumorigenicity 18 protein
Echinococcus multilocularis EmuJ_000598400   suppression of tumorigenicity 18 protein
Homo sapiens ENSG00000196132   myelin transcription factor 1
Homo sapiens ENSG00000186487   myelin transcription factor 1-like
Homo sapiens ENSG00000147488   suppression of tumorigenicity 18, zinc finger
Loa Loa (eye worm) LOAG_15212   hypothetical protein
Mus musculus ENSMUSG00000033740   suppression of tumorigenicity 18
Mus musculus ENSMUSG00000010505   myelin transcription factor 1
Mus musculus ENSMUSG00000061911   myelin transcription factor 1-like
Schistosoma japonicum Sjp_0128990   IPR002515,Zinc finger, C2HC-type,domain-containing
Schistosoma japonicum Sjp_0121660   IPR002515,Zinc finger, C2HC-type,domain-containing
Schmidtea mediterranea mk4.028463.00  
Schmidtea mediterranea mk4.007926.00  
Schmidtea mediterranea mk4.018435.00  
Schmidtea mediterranea mk4.000968.05  

Essentiality

LOAG_15212 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F52F12.6 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens myelin transcription factor 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.011 1 1
0.0122 0.3236 0.488
0.0112 0.2855 0.4569
0.0111 1 1
0.0116 0.256 0.4091
0.0115 0.4431 0.4431
0.0113 0.3861 0.3861
0.0109 0.3576 0.3576
0.011 1 1
0.0118 0.2954 0.438
0.0112 0.2835 0.4344
0.012 0.2789 0.3761
0.0113 0.3643 0.3643
0.0116 0.3053 0.4041
0.0117 1 1
0.0114 1 1
0.0114 0.3057 0.4046
0.0116 0.279 0.4236
0.0116 0.3051 0.4055
0.0116 0.3234 0.3234
0.0116 0.3234 0.3234
0.0113 1 1
0.0122 0.3236 0.488
0.0114 0.2972 0.4863
0.0116 0.3234 0.3234
0.0114 1 1
0.0119 1 1
0.0112 1 1
0.0118 0.2789 0.444
0.0117 0.707 1
0.0116 0.3039 0.4868
0.011 1 1
0.0112 1 1
0.0116 0.4976 0.7557
0.0114 1 1
0.0109 1 1
0.0114 1 1
0.0119 1 1
0.011 1 1
0.0112 1 1
0.0109 0.2773 1
0.011 1 1
0.0117 1 1
0.0112 0.343 0.343
0.0113 0.3643 0.3643
0.0114 1 1
0.0112 0.2733 0.3238

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_15212 (Loa Loa (eye worm)), hypothetical protein
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