pI: 9.994 |
Length (AA): 333 |
MW (Da): 37771 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
41 | 273 | 2ae2 (A) | 4 | 233 | 26.00 | 0 | 1 | 1.0351 | -0.23 |
42 | 102 | 2a4k (A) | 3 | 62 | 32.00 | 0.3 | 0.69 | 0.598183 | -0.46 |
43 | 92 | 1ja9 (A) | 27 | 76 | 42.00 | 0.15 | 0.99 | 0.67515 | -0.56 |
45 | 297 | 3tjr (A) | 9 | 263 | 22.00 | 0 | 1 | 0.95516 | 0.17 |
47 | 140 | 1w6u (A) | 60 | 152 | 30.00 | 0.036 | 1 | 0.761282 | -0.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126812)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G67730 | beta-ketoacyl reductase 1 |
Arabidopsis thaliana | AT1G24470 | beta-ketoacyl reductase 2 |
Brugia malayi | Bm1_44630 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Brugia malayi | Bm1_45995 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Candida albicans | CaO19.3859 | similar to human 17beta-hydroxysteroid dehydrogenase |
Candida albicans | CaO19.11340 | similar to human 17beta-hydroxysteroid dehydrogenase |
Caenorhabditis elegans | CELE_F25G6.5 | Protein STDH-4 |
Caenorhabditis elegans | CELE_C56G2.6 | Protein LET-767, isoform A |
Cryptosporidium hominis | Chro.30277 | F12A21.14 |
Cryptosporidium parvum | cgd3_2370 | steroid dehydrogenase kik-i, putative |
Dictyostelium discoideum | DDB_G0275049 | short-chain dehydrogenase/reductase family protein |
Drosophila melanogaster | Dmel_CG31810 | CG31810 gene product from transcript CG31810-RA |
Drosophila melanogaster | Dmel_CG31809 | CG31809 gene product from transcript CG31809-RB |
Drosophila melanogaster | Dmel_CG1444 | CG1444 gene product from transcript CG1444-RA |
Drosophila melanogaster | Dmel_CG13284 | CG13284 gene product from transcript CG13284-RE |
Echinococcus granulosus | EgrG_000624600 | steroid dehydrogenase |
Echinococcus granulosus | EgrG_000953000 | steroid dehydrogenase |
Entamoeba histolytica | EHI_163540 | estradiol 17-beta-dehydrogenase, putative |
Entamoeba histolytica | EHI_165070 | estradiol 17-beta-dehydrogenase, putative |
Echinococcus multilocularis | EmuJ_000284400 | estradiol 17 beta dehydrogenase 12 |
Echinococcus multilocularis | EmuJ_000953000 | steroid dehydrogenase |
Echinococcus multilocularis | EmuJ_000284700 | steroid dehydrogenase |
Echinococcus multilocularis | EmuJ_000624600 | steroid dehydrogenase |
Giardia lamblia | GL50803_14626 | Oxidoreductase, short chain dehydrogenase/reductase family |
Homo sapiens | ENSG00000149084 | hydroxysteroid (17-beta) dehydrogenase 12 |
Homo sapiens | ENSG00000103160 | hydroxysteroid dehydrogenase like 1 |
Leishmania braziliensis | LbrM.20.0090 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_340010.1 | short chain dehydrogenase, putative |
Leishmania infantum | LinJ.34.0010 | hypothetical protein, conserved |
Leishmania major | LmjF.34.0010 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.33.0010 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_00557 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04043 | hypothetical protein |
Mycobacterium leprae | ML0429c | Probable short-chain type dehydrogenase/reductase |
Mus musculus | ENSMUSG00000034189 | hydroxysteroid dehydrogenase like 1 |
Mus musculus | ENSMUSG00000027195 | hydroxysteroid (17-beta) dehydrogenase 12 |
Mycobacterium tuberculosis | Rv1544 | Possible ketoacyl reductase |
Mycobacterium ulcerans | MUL_1543 | ketoacyl reductase |
Mycobacterium ulcerans | MUL_4860 | ketoacyl reductase |
Mycobacterium ulcerans | MUL_0124 | ketoacyl reductase |
Neospora caninum | NCLIV_035250 | GK18150, related |
Oryza sativa | 4329873 | Os02g0597900 |
Oryza sativa | 4336202 | Os04g0483500 |
Plasmodium berghei | PBANKA_0522400 | steroid dehydrogenase, putative |
Plasmodium falciparum | PF3D7_0422000 | steroid dehydrogenase, putative |
Plasmodium knowlesi | PKNH_0513800 | steroid dehydrogenase, putative |
Plasmodium vivax | PVX_090140 | steroid dehydrogenase, putative |
Plasmodium yoelii | PY05567 | short chain dehydrogenase, putative |
Saccharomyces cerevisiae | YBR159W | ketoreductase |
Schistosoma japonicum | Sjp_0217990 | Estradiol 17-beta-dehydrogenase 12, putative |
Schistosoma japonicum | Sjp_0123070 | IPR002347,Glucose/ribitol dehydrogenase,domain-containing |
Schistosoma japonicum | Sjp_0303510 | Estradiol 17-beta-dehydrogenase 12, putative |
Schistosoma japonicum | Sjp_0058300 | ko:K00100 HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12 [EC:1.1.1.-], putative |
Schistosoma japonicum | Sjp_0211990 | ko:K00044 estradiol 17beta-dehydrogenase [EC1.1.1.62], putative |
Schistosoma mansoni | Smp_168550 | steroid dehydrogenase |
Schistosoma mansoni | Smp_117920 | steroid dehydrogenase |
Schistosoma mansoni | Smp_084570 | steroid dehydrogenase |
Schistosoma mansoni | Smp_009430 | steroid dehydrogenase |
Schistosoma mansoni | Smp_115700 | steroid dehydrogenase |
Schistosoma mansoni | Smp_120510 | steroid dehydrogenase |
Schistosoma mansoni | Smp_168560 | steroid dehydrogenase |
Schistosoma mansoni | Smp_178940 | steroid dehydrogenase |
Schistosoma mansoni | Smp_102190 | steroid dehydrogenase |
Schmidtea mediterranea | mk4.000773.03 | Estradiol 17-beta-dehydrogenase 12 |
Schmidtea mediterranea | mk4.000172.18 | |
Schmidtea mediterranea | mk4.002200.00 | |
Schmidtea mediterranea | mk4.003395.00 | |
Schmidtea mediterranea | mk4.003395.01 | Testosterone 17-beta-dehydrogenase 3 |
Schmidtea mediterranea | mk4.007959.01 | |
Trypanosoma brucei gambiense | Tbg972.5.1680 | T. brucei spp.-specific protein |
Trypanosoma brucei | Tb927.5.1210 | short-chain dehydrogenase, putative |
Trypanosoma congolense | TcIL3000_5_1120 | short-chain dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.509767.170 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.506219.40 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_271888 | 3-ketoacyl-CoA reductase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1572 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.5.1210 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.1210 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.1210 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.5.1210 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C56G2.6 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_C56G2.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C56G2.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C56G2.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C56G2.6 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0522400 | Plasmodium berghei | Essential | plasmo |
TGME49_271888 | Toxoplasma gondii | Probably essential | sidik |
TGME49_271888 | Toxoplasma gondii | Probably non-essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Testosterone 17-beta-dehydrogenase 3 | 306 aa | 34.3% | 274 aa | Compounds | References |
Macaca mulatta | Hydroxysteroid 11-beta dehydrogenase 1 | 140 aa | 23.6% | 144 aa | Compounds | References |