Detailed view for LOAG_05052

Basic information

TDR Targets ID: 947116
Loa Loa (eye worm), hypothetical protein

Source Database / ID:  KEGG  

pI: 8.095 | Length (AA): 403 | MW (Da): 46268 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02815   MIR domain
PF08709   Inositol 1,4,5-trisphosphate/ryanodine receptor

Gene Ontology

Mouse over links to read term descriptions.
GO:0005220   inositol 1,4,5-triphosphate-sensitive calcium-release channel activity  
GO:0070679   GO:inositol 1,4,5 trisphosphate binding  

GO:0005783   endoplasmic reticulum  
GO:0016020   membrane  
GO:0006816   calcium ion transport  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 266 3jrr (A) 2 224 54.00 0 1 1.1116 -0.16
23 402 5gug (A) 6 389 51.00 0 1 1.31223 0.89
26 402 3t8s (A) 9 389 52.00 0 1 1.34828 0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129492)

Species Accession Gene Product
Brugia malayi Bm1_37045   cation channel family protein
Caenorhabditis elegans CELE_F33D4.2   Protein ITR-1, isoform A
Drosophila melanogaster Dmel_CG1063   Inositol 1,4,5,-tris-phosphate receptor
Homo sapiens ENSG00000096433   inositol 1,4,5-trisphosphate receptor, type 3
Homo sapiens ENSG00000123104   inositol 1,4,5-trisphosphate receptor, type 2
Homo sapiens ENSG00000150995   inositol 1,4,5-trisphosphate receptor, type 1
Loa Loa (eye worm) LOAG_07635   hypothetical protein
Loa Loa (eye worm) LOAG_05052   hypothetical protein
Loa Loa (eye worm) LOAG_05051   hypothetical protein
Mus musculus ENSMUSG00000030287   inositol 1,4,5-triphosphate receptor 2
Mus musculus ENSMUSG00000042644   inositol 1,4,5-triphosphate receptor 3
Mus musculus ENSMUSG00000030102   inositol 1,4,5-trisphosphate receptor 1
Schistosoma japonicum Sjp_0068800   ko:K04958 inositol 1,4,5-triphosphate receptor, type 1, putative
Schistosoma japonicum Sjp_0075410   ko:K04959 inositol 1,4,5-triphosphate receptor, type 2, putative
Schistosoma japonicum Sjp_0068790   Inositol 1,4,5-trisphosphate receptor type 1, putative
Schistosoma mansoni Smp_151850   inositol 145-trisphosphate receptor
Schistosoma mansoni Smp_151860   inositol 145-trisphosphate receptor
Schmidtea mediterranea mk4.000868.06   Inositol 1,4,5-trisphosphate receptor, putative
Schmidtea mediterranea mk4.000868.04   Inositol 1,4,5-trisphosphate receptor itr-1
Schmidtea mediterranea mk4.000868.02   Putative inositol 1,4,5-trisphosphate receptor

Essentiality

LOAG_05052 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F33D4.2 Caenorhabditis elegans slow growth wormbase
CELE_F33D4.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Inositol 1,4,5-trisphosphate receptor type 3 Compounds References
Homo sapiens inositol 1,4,5-trisphosphate receptor, type 2 Compounds References
Rattus norvegicus Inositol 1,4,5-trisphosphate receptor type 1 Compounds References
Sus scrofa Type 1 InsP3 receptor isoform S2 Compounds References
Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 Compounds References
Homo sapiens inositol 1,4,5-trisphosphate receptor, type 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.2907 0.6964 1
0.0154 0.2729 0.8705
0.0231 0.5887 1
0.2123 0.3326 0.3467
0.0582 0.6243 1
0.0125 0.5303 1
0.043 0.6331 1
0.12 0.6749 1
0.2365 0.6855 1
0.0436 0.2643 1
0.2123 0.6853 1
0.2816 0.5776 1
0.1539 0.6976 1
0.3365 0.6858 1
0.0125 0.2722 0.5864
0.191 0.3324 0.3465
0.1336 0.7077 1
0.0761 0.4302 1
0.0849 0.7414 1
0.0446 0.3501 1
0.0231 0.5887 1
0.0652 0.3898 1
0.2153 0.4033 0.4032
0.1517 0.6958 1
0.1564 0.306 0.3392
0.0716 0.357 1
0.1214 0.7078 1
0.1278 0.7195 1
0.2335 0.6853 1
0.0127 0.3029 0.4037
0.0845 0.7389 1
0.0212 0.4024 0.4001
0.2816 0.5776 1
0.2816 0.5776 1
0.2816 0.5776 1
0.2816 0.5776 1
0.2153 0.4078 0.4078
0.2816 0.5776 1
0.0849 0.7399 1
0.0339 0.5371 0.7659
0.1278 0.7073 1
0.0051 0.5501 1
0.0114 0.5956 1
0.0694 0.4321 1
0.0211 0.3575 0.3575
0.0206 0.3433 0.3433
0.0668 0.6335 1
0.0445 0.8154 0.8084
0.2153 0.4078 0.4078
0.0161 0.6327 1
0.1514 0.6959 1
0.132671 0.636108 1
0.0443 0.3388 0.8264
0.0656 0.3978 1
0.2365 0.2763 0.3585
0.2907 0.6964 1
0.0668 0.6335 1
0.0443 0.3388 0.8264
0.0467 0.4302 1
0.2759 0.6661 1
0.0223 0.2724 0.6379
0.0355 0.4302 1
0.1255 0.7069 1
0.0103 0.2599 1
0.023 0.5933 1
0.0154 0.2729 0.8705
0.1698 0.3296 0.3296
0.2549 0.3392 0.3506
0.0057 0.5771 1
0.0443 0.2595 1
0.0849 0.7414 1
0.0207 0.5592 1
0.061 0.3626 1
0.0579 0.3765 1
0.018 0.6012 1
0.2816 0.5776 1
0.0055 0.624 1
0.0323 0.5956 1
0.0223 0.4302 0.5617
0.0459 0.2785 0.3631
0.2191 0.6651 1
0.0103 0.2872 1
0.2816 0.5776 1
0.0436 0.2643 1
0.0119 0.3703 0.2664
0.0443 0.3388 0.8264
0.2153 0.3328 0.3469
0.156 0.6907 1
0.2153 0.3328 0.3469
0.0125 0.5303 1
0.0676 0.3614 1
0.12 0.6749 1
0.0582 0.6243 1
0.3733 0.6873 1
0.0581 0.5475 1
0.0681 0.6343 1
0.0545 0.353 0.8292
0.311 0.6675 1
0.2759 0.6661 1
0.0582 0.6243 1
0.0128 0.3459 0.3459
0.0211 0.3575 0.3575
0.2183 0.3322 0.3463
0.0653878 0.251143 1
0.2153 0.4078 0.4078
0.0111 0.4302 1
0.0581 0.5475 1
0.0206 0.615 0.6346
0.0206 0.615 0.6346
0.0849 0.7414 1
0.0057 0.5771 1
0.2153 0.4078 0.4078
0.2549 0.3392 0.3506
0.0115 0.3757 0.6432
0.0443 0.3388 0.8264
0.0545 0.353 0.8292
0.2549 0.3392 0.3506
0.1214 0.7078 1
0.0116 0.3135 0.3135
0.14 0.7065 1
0.0443 0.3388 0.8264
0.0308 0.5592 1
0.0219 0.5758 1
0.1278 0.7195 1
0.0308 0.5592 1
0.0547 0.4415 1
0.1488 0.6958 1
0.2365 0.2763 0.3585
0.156 0.6907 1
0.2816 0.5776 1
0.2494 0.3079 0.3078
0.0668 0.6335 1
0.0051 0.5501 1
0.1182 0.7064 1
0.2816 0.5776 1
0.018 0.6012 1
0.0955 0.7258 1
0.0579 0.3765 1
0.0221 0.5831 1
0.2816 0.5776 1
0.0668 0.6335 1
0.1278 0.7195 1
0.2816 0.5776 1
0.2816 0.5776 1
0.0328 0.6292 0.9747
0.2494 0.3079 0.3078
0.0443 0.3388 0.8264
0.156 0.6907 1
0.2191 0.6651 1
0.0222 0.3659 0.7395
0.116 0.7078 1
0.2153 0.4078 0.4078
0.0221 0.5831 1
0.0128 0.3459 0.3459
0.2816 0.5776 1
0.0212 0.4024 0.3997
0.0443 0.3388 0.8264
0.0581 0.5475 1
0.12 0.6749 1
0.0581 0.4302 0.7308
0.139 0.6957 1
0.0545 0.353 0.8292
0.132671 0.636108 1
0.1182 0.7064 1
0.0076 0.3079 0.3404
0.0231 0.5887 1
0.1613 0.6888 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_05052 (Loa Loa (eye worm)), hypothetical protein
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