Detailed view for LOAG_08743

Basic information

TDR Targets ID: 947152
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 10.8362 | Length (AA): 103 | MW (Da): 11773 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
50 100 3cfu (A) 92 148 33.00 0.41 0.07 0.596146 1.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132070)

Species Accession Gene Product
Brugia malayi Bm1_09425   TPR Domain containing protein
Caenorhabditis elegans CELE_F38B6.6   Protein F38B6.6
Drosophila melanogaster Dmel_CG5038   CG5038 gene product from transcript CG5038-RA
Homo sapiens ENSG00000125247   transmembrane and tetratricopeptide repeat containing 4
Leishmania braziliensis LbrM.20.4230   hypothetical protein, conserved
Leishmania braziliensis LbrM.22.0210   hypothetical protein, unknown function
Leishmania donovani LdBPK_200170.1   Domain of unknown function (DUF1736), putative
Leishmania donovani LdBPK_220090.1   Domain of unknown function (DUF1736), putative
Leishmania infantum LinJ.22.0090   hypothetical protein, unknown function
Leishmania infantum LinJ.20.0170   hypothetical protein
Leishmania major LmjF.20.0150   hypothetical protein
Leishmania major LmjF.22.0220   hypothetical protein, unknown function
Leishmania mexicana LmxM.22.0220   hypothetical protein, unknown function
Leishmania mexicana LmxM.20.0150   hypothetical protein
Loa Loa (eye worm) LOAG_05364   TPR Domain containing protein
Loa Loa (eye worm) LOAG_08742   hypothetical protein
Loa Loa (eye worm) LOAG_08743   hypothetical protein
Mus musculus ENSMUSG00000041594   transmembrane and tetratricopeptide repeat containing 4
Onchocerca volvulus OVOC1877  
Onchocerca volvulus OVOC1878  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08743 (Loa Loa (eye worm)), hypothetical protein
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