Detailed view for LOAG_16193

Basic information

TDR Targets ID: 947488
Loa Loa (eye worm), AStacin protease
Source Database / ID:  KEGG  

pI: 10.2279 | Length (AA): 70 | MW (Da): 8439 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01400   Astacin (Peptidase family M12A)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008237   metallopeptidase activity  
GO:0004222   metalloendopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 70 3edh (A) 1 63 59.00 0 1 1.68927 -0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130155)

Species Accession Gene Product
Caenorhabditis elegans CELE_F38E9.2   Protein NAS-39
Drosophila melanogaster Dmel_CG6868   tolloid
Drosophila melanogaster Dmel_CG6863   tolkin
Echinococcus granulosus EgrG_000640700   Tolloid protein 1
Echinococcus multilocularis EmuJ_000640700   Tolloid protein 1
Homo sapiens ENSG00000038295   tolloid-like 1
Homo sapiens ENSG00000168487   bone morphogenetic protein 1
Homo sapiens ENSG00000095587   tolloid-like 2
Loa Loa (eye worm) LOAG_16193   AStacin protease
Loa Loa (eye worm) LOAG_09658   bone morphogenetic protein 1b
Loa Loa (eye worm) LOAG_09657   hypothetical protein
Mus musculus ENSMUSG00000022098   bone morphogenetic protein 1
Mus musculus ENSMUSG00000053626   tolloid-like
Mus musculus ENSMUSG00000025013   tolloid-like 2
Schistosoma japonicum Sjp_0004770   ko:K09608 tolloid-like protein 1, putative
Schistosoma japonicum Sjp_0004800   Iroquois-class homeodomain protein IRX-1, putative
Schistosoma japonicum Sjp_0130850   IPR000859,CUB,domain-containing
Schistosoma japonicum Sjp_0004780   Tolloid-like protein 2 precursor, putative
Schistosoma japonicum Sjp_0119760   Bone morphogenetic protein 1 homolog precursor, putative
Schistosoma mansoni Smp_134430   subfamily M12A unassigned peptidase (M12 family)
Schmidtea mediterranea mk4.000595.05   Zinc metalloproteinase nas-39
Schmidtea mediterranea mk4.001431.05   Tumor necrosis factor-inducible gene 6 protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens tolloid-like 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.051 0.5905 0.5905
0.0112 0.5443 0.5443
0.0653 0.5831 0.5831
0.0318 0.5551 0.5551
0.0068 0.2751 0.504
0.0151 0.4721 0.4721
0.0951 0.5714 0.5714
0.0715 0.6082 0.5905
0.0242 0.5754 0.5754
0.003 0.5135 0.5135
0.0801 0.5523 0.5523
0.0213 0.4445 0.4769
0.0035 0.5714 0.5714
0.0575 0.6139 0.6139
0.0712014 0.667224 0.667224
0.0035 0.5596 0.5596
0.0891 0.5905 0.5905
0.0035 0.4403 0.4403
0.0524 0.3116 0.5905
0.0213 0.4445 0.4769
0.0157 0.4914 0.4721
0.0197604 0.375371 0.375371
0.006 0.5714 0.5714
0.0035 0.5714 0.5714
0.0035 0.2896 0.2896
0.0197604 0.375371 0.375371
0.1126 0.5977 0.5977
0.0035 0.2523 0.2523
0.0561 0.3843 0.62
0.0324 0.6122 0.6122
0.0088 0.4599 0.4599
0.0035 0.5714 0.5714
0.1411 0.538 0.538
0.1269 0.6179 0.6179
0.0629 0.5566 0.5566
0.0561 0.3843 0.62
0.0035 0.5701 0.5701
0.0059 0.4781 0.4781
0.0659 0.5714 0.5714
0.0057 0.304 0.304
0.1378 0.5714 0.5714
0.0269 0.5869 0.5819
0.0352 0.3211 0.5844
0.105 0.5754 0.5754
0.0149 0.4829 0.5754
0.0063 0.2957 0.4721
0.0373 0.5714 0.5714
0.125314 0.472329 0.472329
0.0531 0.5754 0.5754
0.006 0.4721 0.4721
0.0056 0.2591 0.4721
0.0856 0.573 0.5714
0.0035 0.3968 0.5686
0.0242 0.5754 0.5754
0.1185 0.5554 0.5554
0.032 0.5555 0.5555
0.0521 0.537 0.537
0.0035 0.5714 0.5714
0.0373 0.5714 0.5714
0.0213 0.4445 0.4769
0.0928 0.5754 0.5754
0.0561 0.3843 0.62
0.0415 0.5005 0.5005
0.0561 0.3843 0.62
0.0538 0.6093 0.6093
0.013 0.2509 0.2871
0.0881 0.571 0.5599
0.0035 0.3968 0.5686
0.0035 0.5438 0.5438
0.0412 0.5754 0.5754
0.051 0.3143 0.6204
0.051 0.3143 0.6204
0.0095 0.4721 0.4721
0.065 0.5542 0.5542
0.0115 0.5714 0.5714
0.0575 0.6139 0.6139
0.1344 0.5763 0.5763
0.0147 0.5714 0.5714
0.0248 0.5754 0.5754
0.0122 0.2706 0.3112
0.0324 0.5905 0.5905
0.0751 0.6093 0.6093
0.0035 0.4721 0.4721
0.0197604 0.375371 0.375371
0.0267 0.5714 0.5714
0.1097 0.5714 0.5714
0.0242 0.5754 0.5754
0.0159 0.5325 0.5245
0.0035 0.5714 0.5714
0.0217 0.6126 0.6126
0.0147 0.5714 0.5714
0.0035 0.5484 0.5484
0.0443 0.2919 0.3497
0.1024 0.5845 0.5845
0.0035 0.4358 0.4358
0.0524 0.3116 0.5905
0.009 0.5714 0.5714
0.0157 0.4914 0.4721
0.0035 0.5714 0.5714
0.0581 0.5754 0.5754
0.0524 0.3116 0.5905
0.0035 0.5714 0.5714
0.0561 0.6072 0.6072
0.0386 0.5714 0.5714
0.1187 0.5714 0.5714
0.0035 0.4721 0.4721
0.0156 0.5714 0.5714
0.0332 0.3885 0.4721
0.0096 0.4828 0.5714
0.0157 0.4914 0.4721
0.0155 0.4721 0.4721
0.051 0.5776 0.5754
0.0309 0.6102 0.6102
0.0242 0.5779 0.5754
0.0269 0.5869 0.5819
0.0226 0.2803 0.3805
0.0651 0.5754 0.5754
0.1208 0.6206 0.6204
0.0534 0.6014 0.6014
0.032 0.4721 0.4721
0.0035 0.5714 0.5714
0.0035 0.5714 0.5714
0.0519 0.5754 0.5754
0.0524 0.3116 0.5905
0.0486 0.5869 0.5839
0.0283 0.5288 0.5288
0.0035 0.3106 0.4721
0.0881 0.571 0.5599
0.0178 0.5754 0.5754
0.0932 0.5754 0.5754
0.0801 0.5523 0.5523
0.0616 0.5784 0.5784
0.1949 0.6225 0.6225
0.0058 0.5714 0.5714
0.0155 0.5714 0.5714
0.0286 0.4738 0.4738
0.0029 0.4721 0.4721
0.1208 0.6206 0.6204
0.0527 0.5553 0.5553
0.2092 0.5584 0.5089
0.0188 0.5714 0.5714
0.0128 0.5714 0.5714
0.021 0.4558 0.5714
0.031 0.617 0.6169
0.0094 0.4501 0.4501
0.0035 0.5714 0.5714
0.065 0.5561 0.5561
0.031 0.6079 0.6079
0.003 0.5714 0.5714
0.0438 0.2754 0.4037
0.0893 0.5754 0.5754
0.0213 0.4445 0.4769
0.0602 0.6152 0.6126
0.0162 0.528 0.5256
0.0159 0.5325 0.5245
0.0531 0.5688 0.5688
0.070667 0.64313 0.64313
0.0429 0.4131 0.5993
0.0213 0.4445 0.4769
0.0151 0.4721 0.4721
0.0124 0.5754 0.5754
0.0151 0.4721 0.4721
0.0759 0.6176 0.6176
0.0035 0.4177 0.4177
0.0062 0.2571 0.4612
0.017 0.5714 0.5714
0.0922 0.5799 0.5799
0.0373 0.5714 0.5714
0.0561 0.3843 0.62
0.1411 0.538 0.538
0.0035 0.5714 0.5714
0.0029 0.3208 0.3208
0.0648 0.5688 0.5641
0.0035 0.5714 0.5714
0.051 0.3143 0.6204
0.0307 0.5714 0.5714
0.0062 0.3267 0.3267
0.0057 0.304 0.304
0.0316 0.6099 0.6096
0.0213 0.4445 0.4769
0.1208 0.6206 0.6204
0.0602 0.6152 0.6126
0.003 0.5714 0.5714
0.1937 0.624 0.624
0.0535 0.5714 0.5714
0.0035 0.5619 0.5619
0.0213 0.4445 0.4769
0.0153 0.4812 0.4812
0.0035 0.5318 0.4721
0.1056 0.5754 0.5754
0.0497 0.3105 0.6093
0.0066 0.5754 0.5754
0.0031 0.2911 0.5562
0.0057 0.5714 0.5714
0.0058 0.2504 0.2504
0.0176 0.3423 0.4721
0.0524 0.3116 0.5905
0.0485 0.3842 0.5905
0.0035 0.5714 0.5714
0.0325 0.58 0.58
0.0031 0.5537 0.5537
0.0354 0.3419 0.6052
0.2005 0.6072 0.6024
0.0087 0.4721 0.4721
0.1012 0.5762 0.5754
0.0035 0.4721 0.4721
0.051 0.3143 0.6204
0.0629 0.5566 0.5566
0.0126 0.5754 0.5754
0.0486 0.5869 0.5839
0.0146 0.3077 0.2364
0.0233 0.3875 0.4468
0.0646 0.565 0.548
0.0343 0.586 0.586
0.0124 0.5714 0.5714
0.0988 0.5714 0.5714
0.1399 0.6209 0.6207
0.0157 0.4914 0.4721
0.103 0.6186 0.6174
0.0248 0.5754 0.5754
0.0116 0.5283 0.5283
0.0785 0.5927 0.5927
0.0522 0.5631 0.5631
0.0891 0.5905 0.5905
0.0057 0.565 0.5249
0.0845 0.5754 0.5754
0.0201 0.5714 0.5714
0.0646 0.565 0.548
0.1024 0.5845 0.5845
0.0561 0.3843 0.62
0.0279 0.2869 0.5714
0.0151 0.5482 0.5482
0.0561 0.3843 0.62
0.0035 0.5714 0.5714

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_16193 (Loa Loa (eye worm)), AStacin protease
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