Detailed view for LOAG_04725

Basic information

TDR Targets ID: 947812
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.6532 | Length (AA): 1503 | MW (Da): 173125 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00439   Bromodomain
PF01426   BAH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016586   RSC complex  
GO:0005515   protein binding  
GO:0003682   chromatin binding  
GO:0006338   chromatin remodeling  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
151 444 2r0y (A) 39 308 24.00 0 1 0.376909 -0.11
725 827 5fh7 (A) 661 763 52.00 0 1 0.90043 -2.22
725 827 3tlp (A) 490 593 41.00 0 1 0.74313 -2.24
1009 1159 1w4s (A) 955 1100 50.00 0 1 0.688366 -0.28
1229 1351 1w4s (A) 955 1076 29.00 0.0013 0.92 0.507536 -0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129414)

Species Accession Gene Product
Brugia malayi Bm1_57390   polybromodomain protein
Brugia malayi Bm1_28445   polybromodomain protein
Candida albicans CaO19.9589   two bromodomain protein similar to S. cerevisiae nucleosome remodeling complex component RSC4
Candida albicans CaO19.2964   similar to S. cerevisiae nucleosome remodeling complex component RSC2
Candida albicans CaO19.10481   similar to S. cerevisiae nucleosome remodeling complex component RSC2
Candida albicans CaO19.2041   two bromodomain protein similar to S. cerevisiae nucleosome remodeling complex component RSC4
Caenorhabditis elegans CELE_C26C6.1   Protein PBRM-1, isoform B
Drosophila melanogaster Dmel_CG11375   CG11375 gene product from transcript CG11375-RA
Echinococcus granulosus EgrG_000829600   polybromo 1
Echinococcus multilocularis EmuJ_000829600   polybromo 1
Homo sapiens ENSG00000163939   polybromo 1
Loa Loa (eye worm) LOAG_04725   hypothetical protein
Mus musculus ENSMUSG00000042323   polybromo 1
Saccharomyces cerevisiae YGR056W   Rsc1p
Saccharomyces cerevisiae YLR357W   Rsc2p
Schistosoma japonicum Sjp_0009880   Protein polybromo-1, putative
Schistosoma japonicum Sjp_0008660   Conserved hypothetical protein
Schistosoma mansoni Smp_128120   polybromo-1
Schmidtea mediterranea mk4.000499.04  

Essentiality

LOAG_04725 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C26C6.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C26C6.1 Caenorhabditis elegans larval arrest wormbase
CELE_C26C6.1 Caenorhabditis elegans larval lethal wormbase
CELE_C26C6.1 Caenorhabditis elegans slow growth wormbase
CELE_C26C6.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens polybromo 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0105 0.3323 0.3323

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_04725 (Loa Loa (eye worm)), hypothetical protein
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