Detailed view for LOAG_07479

Basic information

TDR Targets ID: 948593
Loa Loa (eye worm), transcription factor SMAD2

Source Database / ID:  KEGG  

pI: 7.2481 | Length (AA): 443 | MW (Da): 49586 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF03165   MH1 domain
PF03166   MH2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005667   transcription factor complex  
GO:0005622   intracellular  
GO:0005515   protein binding  
GO:0003700   transcription factor activity  
GO:0007179   transforming growth factor beta receptor signaling pathway  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
34 140 5mey (A) 31 138 50.00 0 1 0.964535 -1.64
241 440 1khx (A) 265 464 80.00 0 1 1.44817 -1.21
246 443 3gmj (D) 257 455 66.00 0 1 1.29765 -1.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131716)

Species Accession Gene Product
Brugia malayi Bm1_45525   MH2 domain containing protein
Drosophila melanogaster Dmel_CG2262   Smad on X
Homo sapiens ENSG00000166949   SMAD family member 3
Homo sapiens ENSG00000175387   SMAD family member 2
Loa Loa (eye worm) LOAG_01471   MH2 domain-containing protein
Loa Loa (eye worm) LOAG_07479 this record   transcription factor SMAD2
Mus musculus ENSMUSG00000032402   SMAD family member 3
Mus musculus 17126   SMAD family member 2
Schmidtea mediterranea mk4.007797.02  
Schmidtea mediterranea mk4.001136.10  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens SMAD family member 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0211 0.311 1
0.0839 0.4927 0.5607
0.0144 0.3712 0.3712
0.0144 0.2847 0.5592
0.1075 0.2566 1
0.0761 0.8858 0.8858
0.073 0.3615 1
0.0144 0.5014 1
0.0115 0.4765 0.4765
0.2197 0.5312 1
0.013 0.4319 0.4453
0.0121 0.4964 0.4964
0.0483 0.4325 0.432
0.1799 0.9546 1
0.0267 0.2884 0.3305
0.0826 0.2514 0.612
0.113 0.2621 1
0.0123 0.3283 0.407
0.0964 0.3456 1
0.0131 0.6742 0.7121
0.0144 0.5736 1
0.0118 0.2778 0.2778
0.0123 0.728 0.7876
0.0117 0.4892 0.4892
0.1008 0.3956 0.8349
0.0236 0.2672 0.3827
0.0144 0.4542 0.8132
0.013 0.3881 0.3881
0.2441 0.2927 1
0.0259 0.4071 0.4068
0.0632 0.4344 1
0.045 0.2716 0.7155
0.025 0.2882 1
0.0632 0.4845 0.4845
0.0144 0.4355 0.5302
0.0533 0.4538 1
0.0241 0.285 0.8087
0.0717 0.6899 1
0.1039 0.4562 1
0.0144 0.4836 1
0.0612 0.619 1
0.0117 0.2924 0.2924
0.1248 0.8693 1
0.0131 0.2525 0.2415
0.0731 0.2908 0.534
0.0143 0.2846 0.4375
0.0243 0.4695 0.7457
0.1483 0.3382 0.4873
0.2399 0.7049 1
0.0117 0.3225 0.3225
0.0127 0.2558 0.9262
0.1634 0.4084 1
0.149 0.2781 0.5398
0.0116 0.3208 0.5377
0.0134 0.3178 1
0.0479 0.3348 1
0.0144 0.4405 0.405
0.0138 0.3225 0.4355
0.0144 0.6858 1
0.0144 0.4082 0.5425
0.0144 0.4763 0.4772
0.2565 0.4053 1
0.024 0.5359 0.7632
0.5555 0.4166 1
0.0377 0.4489 1
0.0115 0.6249 1
0.0117 0.5145 0.6354
0.0824 0.3941 0.5854
0.0369 0.3455 0.7193
0.0607 0.4336 1
0.012 0.637 1
0.0144 0.3548 0.3548
0.0764 0.7228 1
0.0252 0.2776 1
0.0241 0.682 1
0.0144 0.4864 0.5563
0.2839 0.3365 0.7958
0.0117 0.4166 0.5489
0.0124 0.2926 0.4368
0.0856 0.5715 0.6487
0.035 0.4787 0.6855
0.0269 0.2818 0.8527
0.0118 0.3258 1
0.0359 0.3039 1
0.0242 0.3117 1
0.0638 0.2922 0.2922
0.6451 0.3941 1
0.0118 0.3636 0.4116
0.0132 0.3244 0.5418
0.0144 0.48 0.55
0.1929 0.4286 0.9003
0.024 0.3267 0.7533
0.1605 0.336 0.7057
0.0128 0.3495 0.3864
0.4947 0.2726 1
0.1031 0.4725 0.9439
0.0391 0.2512 0.7027
0.0242 0.5818 0.5818
0.0364 0.7727 0.7727
0.0488 0.5148 1
0.0124 0.9997 1
0.0113 0.3934 0.5545
0.0144 0.694 0.7816
0.0129 0.2847 1
0.0135 0.2957 0.6351
0.0718 0.2518 0.375
0.0599 0.3635 1
0.0126 0.2582 1
0.0121 0.3888 0.3886
0.1579 0.693 0.6923
0.0239 0.7799 0.7799
0.0144 0.5014 1
0.0144 0.6307 0.7568
0.024 0.2744 1
0.0264 0.277 1
0.4203 0.4005 1
0.0518 0.3075 0.9234
0.0144 0.5014 1
0.0139 0.284 0.4953
0.0254 0.252 0.252
0.1203 0.3474 0.6752
0.0266 0.296 1
0.0416 0.6857 0.9628
0.1706 0.5133 1
0.0483 0.2799 0.3425
0.0383 0.7182 0.7182
0.0983 0.3036 0.3036
0.0235 0.2764 0.2971
0.0144 0.4904 0.5602
0.0144 0.5266 0.5039
0.0251 0.298 0.4825
0.0116 0.3655 0.5205
0.0713 0.4021 0.9718
0.0522 0.5386 1
0.0115 0.4312 0.4312
0.025 0.3478 0.5464
0.0631 0.5226 0.5749
0.0123 0.3293 0.6684
0.0645 0.3716 1
0.0271 0.3219 0.5504
0.0355 0.3564 0.7352
0.1623 0.3828 1
0.2997 0.6002 0.6002
0.0144 0.3025 0.5425
0.186 0.2514 0.801
0.0239 0.38 0.3685
0.0135 0.4924 0.5423
0.014 0.4836 0.5353
0.0243 0.2999 0.568
0.0515 0.3567 0.7784
0.0134 0.2733 0.2726
0.0634 0.3343 0.4223
0.0136 0.8648 0.8648
0.0144 0.9846 0.9846
0.0117 0.495 0.5643
0.0135 0.2964 0.377
0.0237 0.2906 0.6458
0.0123 0.5326 1
0.0115 0.388 0.388
0.1221 0.4614 0.518
0.2055 0.9688 0.9687
0.0236 0.2921 1
0.0348 0.2549 0.5549
0.035 0.3094 0.3086
0.0886 0.2646 1
0.0526 0.6528 0.7913
0.0144 0.7449 1
0.0354 0.2941 0.8165
0.0133 0.5616 1
0.0506 0.507 1
0.0139 0.261 0.6063
0.0492 0.5783 1
0.0144 0.4819 0.5519
0.0238 0.281 0.5709
0.0132 0.6161 1
0.0132 0.5 0.5
0.0492 0.2762 0.7338
0.0254 0.2716 0.4591
0.0603 0.4233 1
0.0741 0.3265 1
0.0252 0.5302 0.9895
0.0615 0.2915 1
0.3858 0.7906 0.7906
0.0132 0.5103 0.6493
0.0983 0.4059 1
0.0131 0.477 0.5452
0.0484 0.2961 0.6772
0.0234 0.4548 0.7163
0.0144 0.4752 1
0.0122 0.513 0.587
0.0349 0.3409 0.6949
0.0347 0.4608 0.5933
0.0142 0.38 0.3736
0.0143 0.3608 0.4192
0.0374 0.4509 0.6068
0.0144 0.3658 0.4175
0.0354 0.4155 0.8288
0.0144 0.4902 0.7703
0.0254 0.252 0.7955
0.0144 0.394 1
0.0118 0.3204 0.4459
0.3123 0.8126 1
0.0237 0.3065 0.8869
0.0862 0.2924 0.2924
0.0369 0.4248 1
0.1247 0.5979 1
0.0498 0.3361 0.3361
0.0144 0.4828 0.4828
0.0124 0.3646 0.3646
0.1339 0.5591 1
0.024 0.2852 0.9831
0.2555 0.4427 0.4427
0.0251 0.8081 1
0.0238 0.935 0.935
0.0131 0.3348 1
0.036 0.5276 1
0.0495 0.2622 0.2622
0.0244 0.2518 0.3694
0.0144 0.4837 0.5537
0.0845 0.3352 0.3413
0.4593 0.4624 1
0.0134 0.9185 0.9185
0.0362 0.4435 1
0.0614 0.3591 0.3906
0.0144 0.4789 0.534
0.0137 0.4676 1
0.0144 0.365 0.7458
0.013 0.3274 0.476
0.0144 0.4598 1
0.0243 0.6393 1
0.0236 0.264 0.6501
0.0127 0.375 0.7634
0.012 0.3027 0.3394
0.0491 0.3197 1
0.0141 0.4107 0.4607
0.0129 0.3746 0.4311
0.0124 0.4841 0
0.1008 0.6102 1
0.0267 0.3051 1
0.0723 0.2685 0.3222
0.0371 0.3628 0.7781
0.0587 0.3599 1
0.0115 0.4613 0.4604
0.996 0.3241 1
0.308 0.4966 0.9752
0.013 0.4109 0.4007
0.0386 0.5336 1
0.317 0.4504 0.4504
0.0758 0.3061 0.5501
0.0136 0.6826 1
0.0997 0.6144 0.653
0.027 0.2956 1
0.0602 0.2666 1
0.0124 0.4841 0
0.0764 0.7228 1
0.3126 0.3801 1
0.0118 0.3593 0.3593
0.0756 0.3013 1
0.0144 0.325 0.6566
0.0144 0.2763 1
0.5611 0.543 1
0.0116 0.5014 1
0.0258 0.2801 0.3943
0.037 0.4311 1
0.0259 0.2584 0.6783
0.0259 0.2508 0.5967
0.047 0.2615 0.2615
0.0907 0.2673 1
0.0238 0.4707 1
0.1977 0.5034 0.8292
0.1922 0.6652 1
0.0119 0.3056 1
0.1217 0.361 0.4915
0.0359 0.4744 0.4813
0.0241 0.281 0.7215
0.0984 0.3074 0.3074
0.0248 0.2738 0.4123
0.0251 0.2691 0.284
0.0406 0.5107 0.8471
0.0134 0.259 0.6391
0.0353 0.7594 1
0.0135 0.3504 0.3491
0.0364 0.5095 1
0.3268 0.4276 1
0.0133 0.3239 0.3239
0.014 0.5686 0.5686
0.0911 0.2897 1
0.0849 0.335 0.4119
0.0367 0.6981 1
0.0144 0.3001 0.2983
0.0616 0.409 1
0.0125 0.3112 1
0.0144 0.3942 1
0.0534 0.3095 0.3095
0.0373 0.4166 1
0.0144 0.4944 0.5642
0.0275 0.2933 0.9879
0.1245 0.3416 1
0.0137 0.2769 0.5599
0.0144 0.3981 0.6212
0.0852 0.2526 0.871
0.0614 0.2794 0.5331
0.0245 0.2953 0.5157
0.0123 0.3677 0.3677
0.0246 0.5387 0.5462
0.0123 0.5113 0.8223
0.0144 0.3333 0.7918
0.0134 0.3634 0.4231
0.014 0.3385 0.3856
0.1326 0.2763 0.4577
0.0124 0.3184 1
0.1574 0.3786 0.483
0.0144 0.2775 1
0.0261 0.3071 1
0.0144 0.2509 1
0.0144 0.2523 0.2921
0.0116 0.3281 0.4784
0.0604 0.2827 0.8096
0.0123 0.3364 1
0.1126 0.2876 0.7568
0.0133 0.3726 0.3666
0.0613 0.3816 0.9695
0.0648 0.2501 1
0.04 0.3937 0.5727
0.0895 0.2642 1
0.0599 0.2582 0.3211
0.0746 0.4502 0.9096
0.1828 0.2547 1
0.1007 0.3593 0.8714
0.087 0.3027 1
0.0736 0.4289 0.5239
0.1448 0.2737 1
0.0254 0.5369 0.5369
0.0233 0.2653 0.472
0.0652 0.9267 1
0.0116 0.3268 0.4648
0.1244 0.3392 1
0.1004 0.2718 1
0.0141 0.697 1
0.0235 0.2545 1
0.0236 0.2802 1
0.0253 0.3028 1
0.0125 0.273 0.613
0.0232 0.2788 0.3593
0.0518 0.329 0.3741
0.0242 0.4891 0.7168
0.1149 0.3829 0.4359
0.076 0.2628 0.897
0.0117 0.3137 0.3276
0.078 0.2694 0.7478
0.3797 0.6993 0.6993
0.0489 0.2591 0.3977
0.8579 0.3249 1
0.0117 0.3836 0.3836
0.047 0.2814 1
0.0264 0.7341 0.7341
0.0135 0.4743 0.4671
0.0138 0.8144 0.8144
0.0849 0.2616 1
0.1079 0.5274 0.72
0.0144 0.3374 1
0.0243 0.2856 1
0.0374 0.4335 1
0.0127 0.373 0.3713
0.0483 0.2865 0.7316
0.0144 0.5477 0.5343
0.0749 0.4622 1
0.0244 0.2763 0.4836
0.0519 0.3307 1
0.0144 0.7329 0.6385
0.0363 0.3632 0.566
0.0238 0.8472 1
0.0117 0.2591 0.2477
0.0127 0.4479 0.4682
0.0144 0.7736 1
0.0108 0.2691 0.4041
0.2976 0.2533 0.8805
0.1115 0.2565 1
0.0116 0.3951 0.3951
0.0761 0.5107 1
0.0359 0.3443 1
0.1225 0.5006 0.5704
0.0377 0.8273 1
0.183 0.2556 0.9842
0.013 0.27 0.2785
0.0134 0.3636 0.4746
0.0486 0.3505 0.3505
0.0117 0.4763 0.5463
0.0366 0.2512 0.9845
0.0257 0.2549 0.984
0.0236 0.2803 0.6537
0.0124 0.3123 0.3774
0.0119 0.3042 0.3042
0.0127 0.3664 0.3473
0.0116 0.3996 0.3465
0.0116 0.4055 0.4055
0.0235 0.8002 0.8226
0.0479 0.4437 0.7158
0.0356 0.2823 1
0.0119 0.3768 0.5515
0.012 0.3716 1
0.1169 0.3193 1
0.996 0.3241 1
0.0252 0.3436 0.5341
0.0242 0.2534 0.4976
0.0144 0.4911 0.5589
0.0964 0.3766 1
0.2068 0.7269 1
0.0379 0.6928 1
0.1191 0.4804 0.815
0.0125 0.259 0.2584
0.0244 0.2736 0.7456
0.0258 0.5647 1
0.0244 0.286 0.7941
0.0123 0.2944 0.3336
0.0604 0.359 0.5065
0.0123 0.3896 0.3896
0.0744 0.2951 0.7448
0.0362 0.7429 1
0.0256 0.4351 1
0.0514 0.3408 0.3408
0.0122 0.4504 0.5616
0.0256 0.3459 1
0.0122 0.471 0.5411
0.0139 0.5568 0.6401
0.0116 0.3306 0.3148
0.0144 0.3225 0.3651
0.0138 0.4355 0.5022
0.0144 0.787 0.8927
0.0144 0.2742 0.5504
0.0128 0.6053 1
0.015 0.3741 0.9864
0.0144 0.2729 0.4426
0.013 0.4862 0.4862
0.0262 0.2782 0.8006
0.0251 0.254 0.8847
0.0249 0.3185 0.9732
0.0598 0.3501 1
0.0122 0.5296 0.6849
0.5362 0.636 1
0.0137 0.2688 0.4462
0.0238 0.3205 0.7056
0.0144 0.2801 0.5923
0.0137 0.3182 0.4637
0.0836 0.4994 0.983
0.0245 0.2832 0.7124
0.0256 0.2795 1
0.0244 0.2675 0.3403
0.0144 0.3014 0.4634
0.0232 0.2747 0.8491
0.0122 0.3632 0.3632
0.049 0.491 1
0.0144 0.4864 0.4978
0.0408 0.2711 1
0.0127 0.3246 0.3195
0.0471 0.2861 0.537
0.0132 0.5227 0.6663
0.0519 0.3289 0.7771
0.0506 0.6579 0.6579
0.0144 0.5722 0.6592
0.0613 0.3764 1
0.0144 0.9066 1
0.0883 0.4492 1
0.0125 0.5016 0.5733
0.0247 0.2893 0.7531
0.0119 0.2959 1
0.0139 0.2519 0.2515
0.1249 0.2556 0.7316
0.0124 0.2847 0.4953
0.0248 0.5335 0.9856
0.0258 0.2509 0.7907
0.0124 0.2729 0.39
0.2667 0.2877 0.7937
0.0137 0.2853 0.3712
0.0116 0.6713 1
0.0136 0.4828 0.5349
0.0397 0.4217 0.7292
0.1011 0.2915 0.952
0.0135 0.2847 1
0.0249 0.5728 0.8042
0.0117 0.2975 0.294
0.1384 0.5278 0.7331
0.0243 0.2698 0.8002
0.0144 0.4838 0.555
0.0119 0.3636 0.4209
0.3463 0.3425 1
0.0236 0.6876 1
0.0263 0.36 1
0.0259 0.4646 0.8491
0.0144 0.3274 1
0.0491 0.2578 0.2574
0.1913 0.5108 0.7479
0.0273 0.2943 0.552
0.0118 0.3176 0.5587
0.0144 0.2742 0.5504
0.012 0.3286 1
0.024 0.8838 1
0.0144 0.3608 1
0.0119 0.2804 0.4872
0.0255 0.3503 1
0.0728 0.5291 1
0.0233 0.2691 0.5537
0.0383 0.4768 1
0.074 0.9124 1
0.0134 0.5404 1
0.0239 0.723 0.723
0.0252 0.2786 1
0.1518 0.3972 1
0.0097 0.6742 1
0.0371 0.4368 1
0.0246 0.5389 1
0.0365 0.4311 1
0.0744 0.4887 0.4885
0.037 0.2943 0.2943
0.1368 0.2968 0.5905
0.0115 0.3805 0.3798
0.037 0.5878 1
0.027 0.5047 0.5047
0.0257 0.3289 1
0.0118 0.6896 1
0.0235 0.2858 0.7148
0.0238 0.5312 0.5657
0.0144 0.6858 1
0.0362 0.4198 1
0.1121 0.3135 1
0.1403 0.2742 1
0.036 0.3699 0.6865
0.0117 0.3768 0.3768
0.0383 0.4499 0.9325
0.4245 0.2677 1
0.024 0.2938 0.8008
0.0128 0.4353 0.4558
0.0144 0.5712 0.9748
0.0144 0.4566 0.4957
0.0179 0.3083 0.3788
0.0365 0.3495 0.4339
0.0538 0.6643 1
0.0989 0.693 1
0.0733 0.2971 0.7587
0.0144 0.2796 0.4898
0.3242 0.3369 1
0.0135 0.2654 0.7631
0.012 0.7355 0.7355
0.1463 0.2505 1
0.0851 0.2595 1
0.0116 0.3803 1
0.0119 0.3385 0.3385
0.0144 0.3779 1
0.0122 0.3414 0.5022
0.0481 0.2563 1
0.0126 0.3194 0.331
0.1129 0.256 0.8876
0.0126 0.2501 0.3595
0.027 0.9685 0.9646
0.1091 0.2545 0.8558
0.0474 0.5776 0.8612
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