Detailed view for LOAG_10785

Basic information

TDR Targets ID: 948848
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 4.8666 | Length (AA): 240 | MW (Da): 27338 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00373   FERM central domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 224 5mv9 (A) 1995 2202 19.00 0.0019 0.58 1.0668 0.01
18 220 4f7g (A) 215 396 18.00 0 1 0.977533 0.07
49 220 5mv9 (A) 2032 2198 27.00 0.000038 1 1.02107 -0.23
130 226 2kup (A) 19 111 22.00 0 0.71 0.623867 -0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127340)

Species Accession Gene Product
Brugia malayi Bm1_30930   MyTH4 domain containing protein
Brugia malayi Bm1_30920   Myosin head containing protein
Caenorhabditis elegans CELE_T10H10.1   Protein HUM-6
Dictyostelium discoideum DDB_G0274455   class VII unconventional myosin
Drosophila melanogaster Dmel_CG7595   crinkled
Drosophila melanogaster Dmel_CG43657   Myosin 10A
Drosophila melanogaster Dmel_CG6976   Myosin 28B1
Echinococcus granulosus EgrG_001038000   myosin XV
Echinococcus granulosus EgrG_000821800   myosin viia
Echinococcus multilocularis EmuJ_000821800   myosin viia
Echinococcus multilocularis EmuJ_001038000   myosin XV
Homo sapiens ENSG00000137474   myosin VIIA
Homo sapiens ENSG00000091536   myosin XVA
Homo sapiens ENSG00000169994   myosin VIIB
Homo sapiens ENSG00000145555   myosin X
Loa Loa (eye worm) LOAG_13688   hypothetical protein
Loa Loa (eye worm) LOAG_10785   hypothetical protein
Loa Loa (eye worm) LOAG_02194   MyTH4 domain-containing protein
Loa Loa (eye worm) LOAG_02192   myosin VIIa
Mus musculus 102635076   serine/arginine repetitive matrix protein 2-like
Mus musculus ENSMUSG00000030761   myosin VIIA
Mus musculus ENSMUSG00000022272   myosin X
Mus musculus ENSMUSG00000024388   myosin VIIB
Mus musculus ENSMUSG00000042678   myosin XV
Onchocerca volvulus OVOC13442  
Schistosoma japonicum Sjp_0025340   Myosin-XV, putative
Schistosoma japonicum Sjp_0092640   Myosin-XV, putative
Schistosoma japonicum Sjp_0060050   Myosin-XV, putative
Schistosoma japonicum Sjp_0101250   IPR000857,Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4,domain-containing
Schistosoma mansoni Smp_127510   myosin XV
Schmidtea mediterranea mk4.030143.00  
Schmidtea mediterranea mk4.002856.03   Myosin-IB
Schmidtea mediterranea mk4.002099.03  
Schmidtea mediterranea mk4.002099.02   Unconventional myosin heavy chain 6

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_10785 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment