Detailed view for LOAG_02766

Basic information

TDR Targets ID: 949028
Loa Loa (eye worm), thyroid receptor interactor
Source Database / ID:  KEGG  

pI: 5.8632 | Length (AA): 580 | MW (Da): 65333 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00018   SH3 domain
PF00611   Fes/CIP4, and EFC/F-BAR homology domain
PF02185   Hr1 repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 292 2efl (A) 2 287 37.00 0 1 0.902879 0.25
327 426 5frg (A) 332 422 32.00 0 0.97 0.496414 -0.86
519 574 2ct4 (A) 8 62 60.00 0.000000000021 1 0.857052 -0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129739)

Species Accession Gene Product
Brugia malayi Bm1_28010   Fes/CIP4 homology domain containing protein
Caenorhabditis elegans CELE_F09E10.8   Protein TOCA-1, isoform B
Dictyostelium discoideum DDB_G0271676   Cdc15/Fes/CIP4 domain-containing protein
Dictyostelium discoideum DDB_G0271812   hypothetical protein
Drosophila melanogaster Dmel_CG15015   Cdc42-interacting protein 4
Echinococcus granulosus EgrG_000125900   thyroid hormone receptor interactor 10
Entamoeba histolytica EHI_148050   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000125900   thyroid hormone receptor interactor 10
Homo sapiens ENSG00000137942   formin binding protein 1-like
Homo sapiens ENSG00000187239   formin binding protein 1
Homo sapiens ENSG00000125733   thyroid hormone receptor interactor 10
Loa Loa (eye worm) LOAG_02766   thyroid receptor interactor
Mus musculus ENSMUSG00000039735   formin binding protein 1-like
Mus musculus ENSMUSG00000019487   thyroid hormone receptor interactor 10
Mus musculus ENSMUSG00000075415   formin binding protein 1
Schistosoma japonicum Sjp_0204640   Formin-binding protein 1-like, putative
Schistosoma mansoni Smp_071150   formin binding protein and related proteins
Schmidtea mediterranea mk4.001082.03   Formin binding protein and related proteins

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0137 0.3036 0.3036
0.0064 0.3347 0.3362
0.0065 0.3464 0.32
0.00394418 0.278418 0.262031
0.0336199 0.276589 0.265254
0.0059 0.3 0.3006
0.0065 0.3464 0.32
0.0351989 0.270507 0.26116
0.0029 0.4037 0.4037
0.0098 0.2621 0.2555
0.0027 0.3179 0.3179
0.0048 0.3625 0.3625
0.0061 1 1
0.0027 0.3179 0.3179
0.0282 0.283 0.4202
0.0378 0.315 0.3101
0.00394418 0.278418 0.262031
0.0039 0.2713 0.2713
0.0048 0.281 0.281
0.018 0.3262 0.3262
0.0075 0.2576 0.2576
0.0282 0.283 0.4202
0.0322685 0.273741 0.262341
0.0029 0.4037 0.4037
0.0137 0.2846 0.2741
0.0039 0.2713 0.2713
0.0068 0.2794 0.2794

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_02766 (Loa Loa (eye worm)), thyroid receptor interactor
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