Detailed view for LOAG_08322

Basic information

TDR Targets ID: 949056
Loa Loa (eye worm), PHD-finger family protein

Source Database / ID:  KEGG  

pI: 8.1385 | Length (AA): 1483 | MW (Da): 168864 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02791   DDT domain
PF15612   WSTF, HB1, Itc1p, MBD9 motif 1

Gene Ontology

Mouse over links to read term descriptions.
GO:0035064   methylated histone residue binding  
GO:0016589   NURF complex  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
248 302 1mm2 (A) 1 60 42.00 0.0000013 1 0.390587 0.69
253 295 2mny (A) 308 356 53.00 0.00027 1 0.481495 0.4
256 296 5vab (A) 28 70 44.00 0 0.98 0.509947 -0.16
256 296 2e6s (A) 29 75 46.00 0.026 1 0.459147 -0.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133298)

Species Accession Gene Product
Brugia malayi Bm1_11520   PHD-finger family protein
Drosophila melanogaster Dmel_CG32346   Enhancer of bithorax
Echinococcus granulosus EgrG_000977000   acetyl coenzyme A C acetyltransferase
Echinococcus multilocularis EmuJ_001115900   fetal alzheimer antigen, falz
Echinococcus multilocularis EmuJ_000977000   acetyl coenzyme A C acetyltransferase
Homo sapiens ENSG00000171634   bromodomain PHD finger transcription factor
Loa Loa (eye worm) LOAG_08322   PHD-finger family protein
Loa Loa (eye worm) LOAG_10716   hypothetical protein
Mus musculus ENSMUSG00000040481   bromodomain PHD finger transcription factor
Schistosoma japonicum Sjp_0081380   expressed protein
Schmidtea mediterranea mk4.001276.06   Nucleosome-remodeling factor subunit NURF301-like

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens bromodomain PHD finger transcription factor Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0277 0.2535 0.2529
0.0111 0.2768 0.2964
0.0112 0.3239 0.3636
0.0092 0.3512 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08322 (Loa Loa (eye worm)), PHD-finger family protein
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