Detailed view for LOAG_08265

Basic information

TDR Targets ID: 949129
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 9.0304 | Length (AA): 370 | MW (Da): 41345 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05743   UEV domain
PF09454   Vps23 core domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0015031   protein transport  
GO:0006464   protein modification process  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 149 3obq (A) 2 145 46.00 0 1 1.00919 -1.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128950)

Species Accession Gene Product
Arabidopsis thaliana AT5G13860   ELC-like protein
Arabidopsis thaliana AT3G12400   protein ELC
Brugia malayi Bm1_08825   hypothetical protein
Candida albicans CaO19.2343   weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101
Candida albicans CaO19.9879   weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101
Caenorhabditis elegans CELE_C09G12.9   Protein TSG-101
Dictyostelium discoideum DDB_G0286797   tumor susceptibility gene 101 protein
Drosophila melanogaster Dmel_CG9712   Tumor susceptibility gene 101 ortholog (H. sapiens)
Echinococcus granulosus EgrG_000664100   tumor susceptibility gene 101 protein
Entamoeba histolytica EHI_178530   tumor susceptibility gene 101 protein, putative
Echinococcus multilocularis EmuJ_000664100   tumor susceptibility gene 101 protein
Homo sapiens ENSG00000074319   tumor susceptibility 101
Loa Loa (eye worm) LOAG_08265   hypothetical protein
Mus musculus ENSMUSG00000014402   tumor susceptibility gene 101
Oryza sativa 4331267   Os02g0833300
Saccharomyces cerevisiae YCL008C   ubiquitin-binding ESCRT-I subunit protein STP22
Schistosoma japonicum Sjp_0313380   Conserved hypothetical protein
Schistosoma japonicum Sjp_0021440   ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative
Schistosoma japonicum Sjp_0014070   Tumor susceptibility gene 101 protein, putative
Schistosoma mansoni Smp_193270   tsg101-related
Schistosoma mansoni Smp_182310   tsg101-related
Schistosoma mansoni Smp_193790   tsg101-related
Schmidtea mediterranea mk4.009690.00   Tumor susceptibility gene 101 protein
Schmidtea mediterranea mk4.000151.06   Tumor susceptibility gene 101 protein
Schmidtea mediterranea mk4.000151.07  
Schmidtea mediterranea mk4.008006.00   Tumor susceptibility gene 101 protein

Essentiality

LOAG_08265 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C09G12.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_C09G12.9 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens tumor susceptibility 101 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0796 1 1
0.0287 0.2883 0.3549
0.0147 0.4025 0.4025
0.1056 1 0.5
0.1202 1 0.5
0.0084 1 0.5
0.0149 0.4025 0.4025
0.0084 0.2634 0.2634
0.0069 0.2732 0.2732
0.0148 0.4044 0.4044
0.0069 0.2507 0.2804
0.0068 0.5062 0.5062
0.036 0.4049 0.4347
0.1065 0.2627 1
0.0084 0.2879 0.2875
0.0145 0.4024 0.4024
0.0084 1 1
0.0149 0.401 0.401
0.0079 0.3833 0.4003
0.1145 0.2548 1
0.1154 1 1
0.0366 1 1
0.1245 1 1
0.0084 0.2869 0.2869
0.1304 1 1
0.0082 0.2614 0.2614
0.0149 0.401 0.401
0.1292 1 1
0.1214 0.28 0.8693
0.1116 0.2888 0.2888
0.014 0.4256 0.4256
0.0084 0.3959 0.2399
0.0068 0.3142 0.4511
0.0071 0.2507 0.2804
0.0084 0.4383 0.4309
0.0145 0.408 0.408
0.1145 0.2548 1
0.1214 0.28 0.8693
0.1058 0.7933 0.7903
0.1065 0.2627 1
0.1153 0.312 0.312
0.0084 0.3893 0.4385
0.1153 0.312 0.312
0.0206 0.7254 1
0.0228 0.3357 0.5758
0.0084 0.2716 0.2716
0.0084 0.2515 0.3252
0.0071 0.2869 0.2869
0.0138 0.4241 0.4241
0.0068 0.5062 0.5062
0.0149 0.401 0.401
0.0084 0.374 0.4226
0.014 0.4167 0.4167
0.1292 1 1
0.0069 0.2764 0.2717
0.0287 0.2883 0.3549
0.0068 0.3654 0.3654
0.1153 0.312 0.312
0.1065 0.2627 1
0.0084 0.5131 0.7715
0.1202 1 0.5
0.0319 0.783 0.7829
0.0139 0.2887 0.4323
0.0861 1 1
0.1202 1 1
0.0149 0.404 0.404
0.0148 0.4025 0.4025
0.1214 0.28 0.8693
0.1065 0.2627 1
0.0067 0.2554 0.4358
0.107 0.418 0.418
0.0437 1 1
0.0084 0.3671 0.3455
0.0152 0.2867 0.2867
0.0149 0.404 0.404
0.0148 0.4025 0.4025
0.0084 0.3534 0.3534
0.0078 0.3264 0.3264
0.0074 0.2571 0.2562
0.0138 0.4155 0.4144
0.0084 0.2515 0.3252
0.0084 0.2571 0.2722
0.0147 0.4044 0.4044
0.0084 0.2507 0.2804
0.1214 0.28 0.8693
0.0138 0.4155 0.4144
0.1254 1 1
0.0084 0.3413 0.3263
0.0149 0.401 0.401
0.015 0.3898 0.3898
0.0149 0.4025 0.4025
0.0299 0.8814 1
0.1153 0.312 0.312
0.036 0.4049 0.4347
0.0084 0.2515 0.3252
0.0084 0.3197 0.3306
0.0074 0.2571 0.2562
0.1214 0.28 0.8693
0.0084 0.6089 1
0.1153 0.312 0.312
0.0287 0.2883 0.3549

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LOAG_08265 (Loa Loa (eye worm)), hypothetical protein
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