Detailed view for LOAG_14450

Basic information

TDR Targets ID: 949280
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 4.3695 | Length (AA): 99 | MW (Da): 11032 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 98 2buj (A) 196 292 41.00 0 1 1.5209 -0.69
2 41 6c9d (A) 221 258 53.00 0.024 0.13 0.69304 1.36
3 86 3ag9 (B) 204 280 32.00 0.2 0.79 1.08948 -0.9
64 97 4mwi (A) 434 467 24.00 0 0.22 0.613334 -0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129834)

Species Accession Gene Product
Arabidopsis thaliana AT5G08160   serine/threonine protein kinase 3
Brugia malayi Bm1_11730   Protein kinase domain containing protein
Candida albicans CaO19_7164   hypothetical protein
Candida albicans CaO19.7164   potential protein kinase similar to S. cerevisiae YPL236C
Caenorhabditis elegans CELE_D2045.7   Protein D2045.7
Dictyostelium discoideum DDB_G0291350   NAK family protein kinase
Drosophila melanogaster Dmel_CG1227   CG1227 gene product from transcript CG1227-RA
Homo sapiens ENSG00000115661   serine/threonine kinase 16
Loa Loa (eye worm) LOAG_14450   hypothetical protein
Loa Loa (eye worm) LOAG_00944   NAK/MPSK protein kinase
Mus musculus ENSMUSG00000026201   serine/threonine kinase 16
Oryza sativa 4346472   Os09g0237600
Oryza sativa 4346899   Os09g0372800
Saccharomyces cerevisiae YPL236C   Env7p
Schistosoma japonicum Sjp_0060270   ko:K08856 serine/threonine kinase 16, putative
Schistosoma mansoni Smp_126460   serine/threonine protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens serine/threonine kinase 16 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0032 0.5 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0023 0.5 0.5
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0064 0.3377 0.3377
0.0032 0.5 0.5
0.0098 0.3242 0.3017
0.0042 0.5 0.5
0.0081 1 1
0.0027 1 1
0.0061 0.6883 0.6883
0.0088 0.4477 0.4477
0.0007 0.5 0.5
0.0039 0.9485 1
0.0092 1 1
0.0093 0.8828 0.8828
0.0022 0.5 0.5
0.0036 0.5 0.5
0.0059 1 1
0.0012 0.5 0.5
0.0081 0.5 0.5
0.0033 0.5 0.5
0.0056 1 1
0.0063 0.7244 0.6686
0.0008 0.5 0.5
0.0016 0.5 0.5
0.0029 0.5 0.5
0.0069 0.3067 0.9179
0.0037 1 0.5
0.0026 0.5 0.5
0.0039 0.5 0.5
0.0063 1 1
0.0091 1 1
0.0039 0.5 0.5
0.0011 1 1
0.0018 0.5 0.5
0.0066 0.3101 0.3068
0.0059 1 1
0.0033 1 1
0.0003 0.5 0.5
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0067 0.5 0.5
0.0062 0.6935 0.6935

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_14450 (Loa Loa (eye worm)), hypothetical protein
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