Detailed view for LOAG_00235

Basic information

TDR Targets ID: 949371
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 7.3969 | Length (AA): 327 | MW (Da): 36763 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00581   Rhodanese-like domain
PF05024   N-acetylglucosaminyl transferase component (Gpi1)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0017176   phosphatidylinositol N-acetylglucosaminyltransferase activity  
GO:0006506   GPI anchor biosynthetic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
182 281 2j6p (A) 4 110 24.00 0 0.87 0.56901 -0.78
182 281 1gmx (A) 4 93 20.00 0 0.99 0.50001 -0.57
185 227 1t3k (A) 1 46 40.00 0.41 0.07 0.226298 2.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129386)

Species Accession Gene Product
Arabidopsis thaliana AT3G57170   N-acetylglucosaminyl transferase component family protein / Gpi1 family protein
Babesia bovis BBOV_III009660   conserved hypothetical protein
Brugia malayi Bm1_39275   hypothetical protein
Candida albicans CaO19.6977   potential N-acetylglucosaminyl transferase component similar to S. cerevisiae GPI1 (YGR216C) involved in GPI anchor synthesis
Caenorhabditis elegans CELE_F01G4.5   Protein F01G4.5
Cryptosporidium hominis Chro.50196   hypothetical protein
Cryptosporidium parvum cgd5_1850   GPI1/PIG-Q like N-acetylglucosaminyl-phosphatidylinositol transferase involved in GIP anchor biosynthesis
Dictyostelium discoideum DDB_G0279515   phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
Drosophila melanogaster Dmel_CG32578   CG32578 gene product from transcript CG32578-RC
Echinococcus granulosus EgrG_000919500   phosphatidylinositol
Entamoeba histolytica EHI_069120   N-acetylglucosaminyl transferase, putative
Echinococcus multilocularis EmuJ_000919500   phosphatidylinositol
Homo sapiens ENSG00000007541   phosphatidylinositol glycan anchor biosynthesis, class Q
Loa Loa (eye worm) LOAG_00235   hypothetical protein
Mus musculus ENSMUSG00000025728   phosphatidylinositol glycan anchor biosynthesis, class Q
Oryza sativa 9269143   Os05g0290300
Plasmodium berghei PBANKA_1118100   phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1, putative
Plasmodium falciparum PF3D7_0618900   phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1
Plasmodium knowlesi PKNH_1131500   phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1, putative
Plasmodium yoelii PY03381   N-acetylglucosamine transferase-related
Saccharomyces cerevisiae YGR216C   Gpi1p
Schistosoma japonicum Sjp_0038020   IPR007720,N-acetylglucosaminyl transferase component,domain-containing
Schistosoma japonicum Sjp_0313100   expressed protein
Schistosoma mansoni Smp_152460   hypothetical protein
Schmidtea mediterranea mk4.001448.03  
Schmidtea mediterranea mk4.009548.01  
Theileria parva TP04_0881   hypothetical protein

Essentiality

LOAG_00235 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YGR216C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1118100 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0005 0.3625 0.3625

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_00235 (Loa Loa (eye worm)), hypothetical protein
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