Detailed view for LOAG_06734

Basic information

TDR Targets ID: 949783
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 10.1313 | Length (AA): 224 | MW (Da): 25126 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 63 1bi8 (A) 241 300 35.00 0.53 0.03 0.38785 1.58
34 63 3gbz (A) 272 301 47.00 0.72 0.2 0.647529 -0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127559)

Species Accession Gene Product
Arabidopsis thaliana AT5G45430   protein kinase superfamily protein
Arabidopsis thaliana AT4G19110   conserved peptide upstream open reading frame 25
Candida albicans CaO19.9931   serine/threonine kinase, positive regulator of meiosis
Candida albicans CaO19.2395   serine/threonine kinase, positive regulator of meiosis
Caenorhabditis elegans CELE_M04C9.5   Protein DYF-5, isoform B
Dictyostelium discoideum DDB_G0268078   RCK family protein kinase
Drosophila melanogaster Dmel_CG42366   CG42366 gene product from transcript CG42366-RA
Echinococcus granulosus EgrG_000591900   serine:threonine protein kinase MAK
Echinococcus multilocularis EmuJ_000591900   serine:threonine protein kinase MAK
Giardia lamblia GL50803_6700   Kinase, CMGC RCK
Homo sapiens ENSG00000111837   male germ cell-associated kinase
Homo sapiens ENSG00000112144   intestinal cell (MAK-like) kinase
Leishmania braziliensis LbrM.27.0110   protein kinase, putative
Leishmania braziliensis LbrM.19.0490   mitogen activated protein kinase, putative,map kinase, putative
Leishmania donovani LdBPK_270100.1   protein kinase, putative
Leishmania donovani LdBPK_190170.1   mitogen-activated protein kinase 9, putative
Leishmania infantum LinJ.19.0170   mitogen activated protein kinase, putative,map kinase, putative
Leishmania infantum LinJ.27.0100   protein kinase, putative
Leishmania major LmjF.27.0100   protein kinase, putative
Leishmania major LmjF.19.0180   mitogen activated protein kinase, putative,map kinase, putative
Leishmania mexicana LmxM.19.0180   mitogen activated protein kinase, putative,map kinase, putative
Leishmania mexicana LmxM.27.0100   protein kinase, putative
Loa Loa (eye worm) LOAG_06734   hypothetical protein
Loa Loa (eye worm) LOAG_12455   CMGC/RCK/MAK protein kinase
Mus musculus ENSMUSG00000009828   intestinal cell kinase
Mus musculus ENSMUSG00000021363   male germ cell-associated kinase
Oryza sativa 4330434   Os02g0700600
Oryza sativa 4339927   Os06g0116100
Saccharomyces cerevisiae YJL106W   Ime2p
Schistosoma japonicum Sjp_0307390   ko:K03127 transcription initiation factor TFIID subunit D11, putative
Schistosoma japonicum Sjp_0065020   Oxysterol-binding protein-related protein 9, putative
Schistosoma japonicum Sjp_0098600   IPR000719,Protein kinase;IPR006163,Phosphopantetheine-binding;IPR011009,Protein kinase-like,domain-containing
Schistosoma mansoni Smp_132890   serine/threonine protein kinase
Schmidtea mediterranea mk4.002465.00  
Schmidtea mediterranea mk4.001636.02  
Trypanosoma brucei gambiense Tbg972.10.17970   protein kinase, putative
Trypanosoma brucei gambiense Tbg972.3.300   protein kinase, putative
Trypanosoma brucei Tb927.3.690   CMGC/RCK protein kinase, putative
Trypanosoma brucei Tb927.10.14800   mitogen-activated protein kinase 9, putative
Trypanosoma congolense TcIL3000_10_12670   mitogen-activated protein kinase 9, putative
Trypanosoma cruzi TcCLB.509719.50   CMGC/RCK protein kinase, putative
Trypanosoma cruzi TcCLB.506211.180   mitogen-activated protein kinase 9, putative
Trypanosoma cruzi TcCLB.509231.20   CMGC/RCK protein kinase, putative
Trypanosoma cruzi TcCLB.511289.50   mitogen-activated protein kinase 9, putative
Trichomonas vaginalis TVAG_129430   CMGC family protein kinase
Trichomonas vaginalis TVAG_529130   CMGC family protein kinase
Trichomonas vaginalis TVAG_399660   CMGC family protein kinase
Trichomonas vaginalis TVAG_583940   CMGC family protein kinase

Essentiality

LOAG_06734 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.690 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.3.690 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.690 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.3.690 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.14800 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14800 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.14800 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.14800 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens intestinal cell (MAK-like) kinase Compounds References
Homo sapiens male germ cell-associated kinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_06734 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment