Detailed view for LOAG_08569

Basic information

TDR Targets ID: 949904
Loa Loa (eye worm), GTP-ase activating protein for Arf containing protein
Source Database / ID:  KEGG  

pI: 8.0169 | Length (AA): 720 | MW (Da): 81175 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain
PF01412   Putative GTPase activating protein for Arf

Gene Ontology

Mouse over links to read term descriptions.
GO:0005096   GTPase activator activity  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
283 376 1fao (A) 166 261 22.00 0 0.74 0.471356 -1.32
388 462 2crw (A) 1 75 40.00 0.0000001 0.84 0.561667 -0.01
404 644 2b0o (G) 426 676 29.00 0 1 0.678522 -0.25
404 653 3lvq (E) 426 16 32.00 0 1 0.701722 -0.12
404 610 1dcq (A) 249 470 37.00 0 1 0.702 -0.32
615 714 5gp7 (A) 829 933 10.00 0.0000037 0.05 0.250889 -0.77
616 715 1awc (B) 31 135 10.00 0.00000057 0.08 0.245889 -0.69
628 715 5jhq (A) 221 313 13.00 0.0000048 0.05 0.283222 -0.96
632 714 3hra (A) 48 137 12.00 0.01 0.13 0.221278 -0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129717)

Species Accession Gene Product
Brugia malayi Bm1_09300   GTP-ase activating protein for Arf containing protein
Drosophila melanogaster Dmel_CG30372   ArfGAP with SH3 domain, ankyrin repeat and PH domain
Echinococcus granulosus EgrG_001104300   arf GAP with SH3 domain ANK repeat and PH
Entamoeba histolytica EHI_045400   Arf GTPase activating protein, putative
Entamoeba histolytica EHI_138360   ARF GTPase activating protein, putative
Echinococcus multilocularis EmuJ_001104300   arf GAP with SH3 domain, ANK repeat and PH
Homo sapiens ENSG00000153317   ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Homo sapiens ENSG00000088280   ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Homo sapiens ENSG00000151693   ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Loa Loa (eye worm) LOAG_08569   GTP-ase activating protein for Arf containing protein
Mus musculus ENSMUSG00000036995   ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Mus musculus ENSMUSG00000022377   ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Mus musculus ENSMUSG00000052632   ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Saccharomyces cerevisiae YDR524C   Age1p
Schistosoma mansoni Smp_125430   development and differentiation-enhancing factor ddef
Schmidtea mediterranea mk4.001438.02   Putative development and differentiation-enhancing factor, ddef
Schmidtea mediterranea mk4.001438.01   Putative development and differentiation-enhancing factor, ddef
Schmidtea mediterranea mk4.012933.00   Putative development and differentiation-enhancing factor, ddef

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0035 0.4354 0.4585
0.0034 0.2669 0.2669
0.0038 0.8181 1
0.0037 0.8162 0.824
0.0037 0.4354 0.4585

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08569 (Loa Loa (eye worm)), GTP-ase activating protein for Arf containing protein
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