Detailed view for LOAG_00135

Basic information

TDR Targets ID: 950191
Loa Loa (eye worm), disintegrin family protein
Source Database / ID:  KEGG  

pI: 8.3826 | Length (AA): 902 | MW (Da): 100656 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13574   Metallo-peptidase family M12B Reprolysin-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0008237   metallopeptidase activity  
GO:0004222   metalloendopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
293 735 6be6 (A) 247 654 48.00 0 1 0.885531 0.23
558 622 3c05 (A) 5 59 35.00 0 0.89 0.371862 -0.79
579 630 2ech (A) 1 48 25.00 0 0.37 0.33945 -1.16
852 893 1nay (A) 106 145 28.00 0.19 0.01 0.149663 0.98

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131201)

Species Accession Gene Product
Brugia malayi Bm1_55800   Disintegrin family protein
Caenorhabditis elegans CELE_DY3.7   Protein SUP-17
Drosophila melanogaster Dmel_CG1964   Kuzbanian-like
Drosophila melanogaster Dmel_CG7147   kuzbanian
Echinococcus granulosus EgrG_001069300   disintegrin and metalloproteinase
Echinococcus multilocularis EmuJ_001069300   disintegrin and metalloproteinase
Homo sapiens 102   ADAM metallopeptidase domain 10
Loa Loa (eye worm) LOAG_00135   disintegrin family protein
Mus musculus ENSMUSG00000054693   a disintegrin and metallopeptidase domain 10
Schistosoma japonicum Sjp_0061450   ko:K04712 fatty acid desaturase, putative
Schistosoma mansoni Smp_145900   dihydroceramide desaturase
Schmidtea mediterranea mk4.004725.01  
Schmidtea mediterranea mk4.021321.00   ADAM 10
Schmidtea mediterranea mk4.000883.08  
Schmidtea mediterranea mk4.011942.00  
Schmidtea mediterranea mk4.007155.00  
Schmidtea mediterranea mk4.017082.00   Disintegrin and metalloproteinase domain containing protein-2
Schmidtea mediterranea mk4.035441.00   ADAM 10
Schmidtea mediterranea mk4.000822.05  
Schmidtea mediterranea mk4.006007.01  
Schmidtea mediterranea mk4.004725.00  
Schmidtea mediterranea mk4.002575.00  
Schmidtea mediterranea mk4.000883.07  
Schmidtea mediterranea mk4.002575.01  
Schmidtea mediterranea mk4.004969.02  

Essentiality

LOAG_00135 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_DY3.7 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ADAM metallopeptidase domain 10 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus ADAM17 827 aa 26.9% 774 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0398 0.3121 0.3726
0.00966253 0.397192 0.397192
0.0139 0.3404 0.4306
0.0074 0.4978 1
0.0074 0.4978 1
0.0338 0.2748 0.3965
0.0074 0.4978 1
0.0778 0.2762 0.3835
0.0778 0.2762 0.3835
0.0778 0.2762 0.3835
0.0778 0.2762 0.3835
0.0071 0.6455 1
0.0074 0.3477 0.5645
0.0074 0.4978 1
0.0778 0.2762 0.3835
0.0074 0.4978 1
0.0061 0.4978 1
0.0074 0.4978 1
0.00966253 0.397192 0.397192
0.0074 0.4978 1
0.0074 0.4978 1
0.0793 0.286 0.4296
0.0395 0.2536 0.3759
0.1743 0.2935 0.4411
0.0778 0.2762 0.3835
0.0778 0.2762 0.3835
0.057 0.4447 0.4443
0.0769 0.2673 0.2942
0.0066 0.2567 0.2405
0.0141 0.6861 1
0.0074 0.4978 1
0.0074 0.4978 1
0.0778 0.2762 0.3835
0.0074 0.4978 1
0.0778 0.2762 0.3835
0.0793 0.286 0.4296
0.0539 0.3831 0.383
0.0067 0.26 0.26
0.0074 0.3477 0.5645
0.0074 0.4978 1
0.0418 0.5251 0.7908

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_00135 (Loa Loa (eye worm)), disintegrin family protein
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