Detailed view for LOAG_07388

Basic information

TDR Targets ID: 950429
Loa Loa (eye worm), dehydrogenase
Source Database / ID:  KEGG  

pI: 9.8032 | Length (AA): 354 | MW (Da): 39097 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00106   short chain dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
35 301 2qq5 (A) 4 262 51.00 0 1 1.30104 -0.7
35 80 2d5c (A) 114 157 43.00 0.76 0.86 0.699044 -1.11
35 118 3mje (A) 216 296 31.00 0.31 1 0.718088 -1.44
36 322 5yss (A) 3 250 32.00 0.0000000013 1 0.973534 -0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134637)

Species Accession Gene Product
Brugia malayi Bm1_31830   dehydrogenases, short chain protein 9
Caenorhabditis elegans CELE_Y32H12A.3   Protein DHS-9
Echinococcus granulosus EgrG_000410100   Dehydrogenase:reductase SDR family
Echinococcus multilocularis EmuJ_000410100   Dehydrogenase:reductase SDR family
Homo sapiens ENSG00000157379   dehydrogenase/reductase (SDR family) member 1
Loa Loa (eye worm) LOAG_07388   dehydrogenase
Mus musculus ENSMUSG00000002332   dehydrogenase/reductase (SDR family) member 1
Mycobacterium ulcerans MUL_2755   oxidoreductase
Schistosoma japonicum Sjp_0214470   ko:K00120 similar to Dehydrogenase/reductase (SDR family) member 1 [EC:1.1.-.-], putative
Schistosoma japonicum Sjp_0214460   ko:K00120 Dehydrogenase/reductase (SDR family) member 1 [EC:1.1.-.-], putative
Schistosoma japonicum Sjp_0057930   Dehydrogenase/reductase SDR family member 1, putative
Schistosoma japonicum Sjp_0219320   expressed protein
Schistosoma mansoni Smp_171960   short chain dehydrogenase
Schistosoma mansoni Smp_171030   short chain dehydrogenase
Schmidtea mediterranea mk4.041724.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Canis lupus familiaris 11-beta-hydroxysteroid dehydrogenase type 1 293 aa 23.1% 242 aa Compounds References
Staphylococcus aureus subsp. aureus MRSA252 Enoyl-[acyl-carrier-protein] reductase 256 aa 26.9% 238 aa Compounds References
Cochliobolus lunatus 17-beta-hydroxysteroid-dehydrogenase 270 aa 27.9% 229 aa Compounds References
Rattus norvegicus 11-beta-hydroxysteroid dehydrogenase 1 288 aa 23.2% 241 aa Compounds References
Staphylococcus aureus Enoyl-ACP reductase 243 aa 26.9% 238 aa Compounds References
Staphylococcus aureus Enoyl-[acyl-carrier-protein] reductase [NADPH] 256 aa 26.9% 238 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0039 1 1
0.0196 0.8679 0.8679
0.0021 0.3321 0.3321
0.0097 1 1
0.008 0.5 0.5
0.0009 0.5 0.5
0.0058 0.3931 0.5176
0.0068 1 1
0.0131 0.5 0.5
0.0132 0.3658 0.3658
0.0102 0.7451 0.1796
0.0196 0.8679 0.8679
0.0073 0.4546 0.4546
0.0068 0.2585 0.4116
0.0071 0.3141 0.3141
0.0408 0.5144 1
0.0082 1 0.5
0.0005 0.5 0.5
0.0009 0.5 0.5
0.0004 0.5 0.5
0.0106 0.2872 0.4415
0.0093 0.5 0.5
0.0106 1 1
0.0009 0.7374 0.7374
0.0004 0.5 0.5
0.0157 0.5 0.5
0.0165 1 1
0.007 0.2916 0.4349
0.0089 0.5 0.5
0.0027 0.5 0.5
0.0119 0.2746 1
0.004 0.5 0.5
0.0114 1 1
0.0016 0.5 0.5
0.0066 0.3586 0.3586
0.016 0.577 1
0.0089 0.5 0.5
0.0009 1 0.5
0.0027 0.5 0.5
0.0045 1 1
0.0196 0.8679 0.8679
0.0053 1 1
0.0106 1 1
0.0012 0.5 0.5
0.0087 0.5 0.5
0.0032 1 1
0.0088 0.6544 0.6544
0.0004 0.5 0.5
0.0058 1 1
0.0019 0.4322 1
0.0108 0.5 0.5
0.016 0.577 1
0.0076 1 1
0.0005 0.5 0.5
0.0009 0.5 0.5
0.0046 0.3082 0.3082
0.0408 0.5144 1
0.0068 1 1
0.0009 0.5 0.5
0.0013 0.5 0.5
0.0009 0.5 0.5
0.0035 1 1
0.0009 0.5 0.5
0.0118 1 1
0.0057 0.284 0.2719
0.0073 0.2873 0.2873
0.007 1 1
0.0009 0.5 0.5
0.0171 0.4063 0.4063
0.0402 1 1
0.011 0.3568 0.3568
0.007 1 1
0.0073 0.3811 0.3811
0.007 0.2916 0.4349
0.0012 0.5 0.5
0.0222 0.5 0.5
0.0097 0.4304 1
0.0056 0.875 0.875
0.0004 0.5 0.5
0.0073 0.3141 1
0.0084 0.4283 0.4283
0.0056 1 1
0.0013 1 1
0.0067 0.3468 0.3468
0.007 0.2916 0.4349
0.0073 0.3811 0.3811
0.0004 0.5 0.5
0.0009 0.5 0.5
0.0171 0.4063 0.4063
0.007 1 1
0.0162 1 1
0.0021 0.3321 0.3321
0.0088 1 1
0.0114 1 1
0.0106 0.5 0.5
0.0053 1 1
0.0004 0.5 0.5
0.0123 0.5 0.5
0.0026 0.5 0.5
0.0064 0.3508 0.411
0.0021 0.5 0.5
0.0113 1 1
0.0004 0.5 0.5
0.0085 1 1
0.0218 0.5 0.5
0.0408 0.5144 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_07388 (Loa Loa (eye worm)), dehydrogenase
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