Detailed view for LOAG_03827

Basic information

TDR Targets ID: 950501
Loa Loa (eye worm), leukotriene A4 hydrolase
Source Database / ID:  KEGG  

pI: 6.5854 | Length (AA): 565 | MW (Da): 63962 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01433   Peptidase family M1 domain
PF09127   Leukotriene A4 hydrolase, C-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0008237   metallopeptidase activity  
GO:0005488   binding  
GO:0006508   proteolysis  

Metabolic Pathways

Arachidonic acid metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 564 2xq0 (A) 103 670 33.00 0 1 1.34368 -0.02
8 564 3u9w (A) 1051 1608 46.00 0 1 1.60614 -0.88

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129538)

Species Accession Gene Product
Arabidopsis thaliana AT5G13520   peptidase M1 family protein
Candida albicans CaO19.992   leukotriene A4 hydrolase/leucyl aminopeptidase
Candida albicans CaO19.8607   leukotriene A4 hydrolase/leucyl aminopeptidase
Caenorhabditis elegans CELE_ZC416.6   Protein ZC416.6
Caenorhabditis elegans CELE_C42C1.11   Protein C42C1.11, isoform B
Dictyostelium discoideum DDB_G0269148   leukotriene A4 hydrolase
Drosophila melanogaster Dmel_CG10602   CG10602 gene product from transcript CG10602-RE
Echinococcus granulosus EgrG_000972400   leukotriene A 4 hydrolase
Echinococcus multilocularis EmuJ_000972400   leukotriene A 4 hydrolase
Homo sapiens ENSG00000111144   leukotriene A4 hydrolase
Loa Loa (eye worm) LOAG_03827   leukotriene A4 hydrolase
Mus musculus ENSMUSG00000015889   leukotriene A4 hydrolase
Oryza sativa 4334583   Os03g0819100
Saccharomyces cerevisiae YNL045W   Lap2p
Schistosoma japonicum Sjp_0022850   ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative
Schistosoma mansoni Smp_007550   leukotriene A4 hydrolase (M01 family)
Schmidtea mediterranea mk4.000242.04   Leukotriene A-4 hydrolase
Schmidtea mediterranea mk4.022487.00  
Schmidtea mediterranea mk4.019620.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus leukotriene A4 hydrolase Compounds References
Homo sapiens leukotriene A4 hydrolase Compounds References
Cavia porcellus Leukotriene A-4 hydrolase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.2696 1 1
0.5857 0.4831 0.4831
0.2188 1 1
0.0558 1 1
0.0469 0.5314 1
0.0239 0.2843 0.9926
0.0558 0.5 0.5
0.0495 0.2821 1
0.047 0.2759 0.9779
0.2229 1 1
0.0998 0.79 1
0.0281 0.3177 0.36
0.0226 1 1
0.0279 0.2722 0.3226
0.1179 1 1
0.0232 0.6135 1
0.0719 1 1
0.0752 0.3731 0.3728
0.7965 0.328 0.328
0.0558 1 1
0.4068 0.2804 0.2804
0.1179 1 1
0.1689 1 1
0.0453 0.544 1
0.0223 0.2583 0.2907
0.5517 1 1
0.0279 0.3336 1
0.0279 0.5 0.5
0.0558 0.5 0.5
0.0279 0.6064 0.5789
0.0279 1 1
0.0754 0.3072 1
0.0158 0.886 0.886
0.293397 1 1
0.1858 1 1
0.0257 0.5593 0.5593
0.2605 1 1
0.0279 0.3517 0.3509
0.7024 1 1
0.0126 0.4176 0.3586
0.1724 1 1
0.0279 1 1
0.3281 0.2754 1
0.0279 0.5969 1
0.0418 0.2603 1
0.1647 0.9894 0.9894
0.0232 0.378 0.9069
0.0228 0.2549 0.7236
0.0558 1 1
0.0241 0.333 0.333
0.0469 0.2594 1
0.1441 1 1
0.047 0.2759 0.9779
0.0279 1 1
0.2583 1 1
0.0697 1 0.5
0.0231 0.6205 0
0.0558 0.6865 1
0.3058 0.4781 0.4781
0.5517 1 1
0.1692 1 1
0.2363 0.6292 1
0.0584 0.7793 1
0.4025 1 1
0.0225 0.2654 0.5115
0.0228 0.2752 0.3668
0.3993 1 1
0.0279 0.4881 0.4872
0.0279 0.5654 0.5649
0.0239 0.5543 0.6011
0.0279 1 1
0.3281 0.2754 1
0.046 0.3053 1
0.0227 0.6296 0.6296
0.048 0.8578 1
0.0279 0.314 0.7536
0.2356 1 1
0.0099 0.2939 0.2815
0.2372 0.434 0.434
0.0301 0.3401 0.3401
0.0279 0.2515 0.2515
0.0479 1 1
0.5857 0.4831 0.4831
0.0981 1 1
0.0692 0.2662 0.2595
0.0279 0.2722 0.3226
0.6677 1 1
0.0232 0.3485 0.3465
0.0456 1 1
0.0226 0.6577 0.6719
0.2564 1 1
0.182 1 1
0.0701 1 1
0.3281 0.2754 1
0.0226 0.34 1
0.0455 0.5334 0.7272
0.0234 0.3065 0.3502
0.1186 1 1
0.0759 0.2688 0.5827
0.833 0.4684 1
0.1918 1 1
0.5097 1 1
0.0226 0.2801 0.4513
0.0227 0.2747 0.3396
0.0692 0.7041 1
0.023 0.2853 0.2842
0.0238 0.2852 0.9114
0.2145 1 1
0.045 1 0.5
0.3137 1 1
0.3796 0.3446 0.3446
0.0663139 1 1
0.4328 1 1
0.0279 1 0.5
0.0279 0.2853 0
0.0279 0.5 0.5
0.4377 0.2505 0.2505
0.0237 0.2658 0.4649
0.2686 1 1
0.4397 1 0.5
0.0279 0.7876 1
0.8031 0.4743 1
0.1051 1 1
0.0231 0.5043 1
0.0225 0.2822 0.334
0.1051 1 1
0.0223 0.6611 0.7592
0.047 0.3636 0.7433
0.7965 0.328 0.328
0.1867 0.3705 0.7897
0.0939 1 1
0.0469 1 1
1.1759 0.307 1
0.0279 0.3767 0.3767
0.0558 1 1
0.0357 0.773 1
0.0463 0.2935 0.6953
0.0279 0.9709 1
0.7965 0.328 0.328
0.0223 0.6457 0.6457
0.0279 0.3767 0.3767
0.1767 0.3704 0.37
0.0255 1 1
0.0478 0.3238 0.3238
0.2564 1 1
0.141 0.6773 1
0.0194 0.318 0.0538
0.7965 0.328 0.328
0.0279 1 1
0.4421 0.3657 0.3657
0.0452 0.5142 1
0.0352 0.7276 0.7272
0.2651 1 1
0.0259 0.9983 1
0.0229 0.3192 1
0.0954 1 1
0.118 1 1
0.0575 0.3459 0.3459
0.0688 0.6578 0.6557
0.3321 1 1
0.0234758 0.663034 0.663034
0.0229 0.3135 0.7431
0.245 1 1
0.0104 0.315 0.315
0.1541 0.8189 1
0.0744 1 1
0.0279 1 0.5
0.0469 1 1
0.0279 0.4009 1
0.2885 1 1
0.0279 0.2529 0.5019
0.0492 0.8505 0.8505
0.3281 0.2754 1
0.0462 0.2772 1
0.0281 0.3177 0.36
0.0989 1 1
0.1626 0.3278 0.3277
0.0855 0.3451 1
0.0456 0.356 0.3553
0.1722 1 1
0.0174 0.3281 0.3281
0.7965 0.328 0.328
0.3937 0.2506 0.2506
0.0279 0.2897 0.2897
0.2362 0.395 1
0.2885 1 1
0.0239 0.5543 0.6011
0.0264 1 1
0.2852 1 1
0.2179 1 1
0.1722 1 1
0.2684 0.9778 1
0.1614 0.3251 0.3251
0.2326 1 1
0.1725 1 1
0.1658 1 1
0.0279 0.5977 0.6802
0.0771 1 1
0.0684 0.6966 1
0.0279 1 0.5
0.1179 1 1
0.0471 0.8822 1
0.1875 1 1
0.0231 0.4548 0.6093
0.1723 1 1
0.0711 0.8019 1
0.0492 0.4999 0.4509
0.0258 0.3693 0.9949
0.0279 0.3022 0.3463
0.4887 1 1
0.3089 1 1
0.0232 0.2755 0.2755
0.0998 0.79 1
0.4386 0.3961 1
0.0279 0.5 0.5
0.0504 1 0.5
0.0375 1 1
0.0558 0.5 0.5
0.0228 1 1
0.2878 1 1
0.0466 0.6754 1
0.0223 1 1
0.0279 0.5 0.5
0.1394 1 1
0.3281 0.2754 1
0.3709 1 1
0.0279 1 0.5
0.3394 0.3719 0.3717
0.2708 0.2874 1
0.0229 0.4952 0.4952
0.0342 0.365 1
1.4053 1 1
0.0558 0.443 1
0.0225 0.5882 0.5882
0.3281 0.2754 1
0.046 0.3053 1
0.0228 0.2549 0.7236
0.3944 0.7573 1
0.3338 1 1
0.0558 1 0.5
0.0497 1 1
0.1658 1 1
0.1725 1 1
0.0234 0.9382 0.9346
0.0279 1 1
0.3338 1 1
0.0255 0.6652 0.6652
0.0225 0.3781 0.9795
0.0918 0.5578 1
0.1681 0.8339 1
0.1378 0.3507 0.3507
0.1681 0.8339 1
0.046 0.3999 0.247
0.0232 0.2752 0.3669
0.0963 0.2593 1
0.1901 1 1
0.023 0.2853 0.2842
0.0558 1 1
0.0223 0.2836 0.7297
0.0158 0.3458 0.588
0.0229 0.7726 0.7726
0.3937 0.2506 0.2506
0.0279 0.5 0.5
0.1459 1 1
0.0711 0.2611 0.2709
0.1871 0.6645 1
0.7965 0.328 0.328
0.7965 0.328 0.328
0.4962 1 1
0.5685 1 1
0.0279 0.4881 0.4872
0.2374 1 1
0.0466 0.5485 1
0.7965 0.328 0.328
0.0235 0.282 1
0.260332 0.5 0.5
0.0691 0.2757 1
0.4386 0.3961 1
0.1374 1 1
0.0426 0.512 1
0.0267 0.9332 0.9332
0.3237 1 1
0.0279 0.5 0.5
0.6093 1 1
0.6198 0.3062 0.3062
0.5517 1 1
0.0737 1 1
0.3944 0.7573 1
0.0279 0.3752 0.6366
0.0144 0.3242 0.3242
0.0478 1 1
0.0676 0.7163 1
0.7965 0.328 0.328
0.0279 0.6485 0.6482
0.0279 0.3634 0.3634
0.0301 0.3418 0.3418
0.1015 1 1
0.26 0.5 0.5
0.7965 0.328 0.328
0.2887 0.4347 0.9484
0.2345 0.3882 1
0.0279 0.9077 1
0.0517 0.343 0.343
0.0234 0.3092 0.4065
0.0232 0.2668 0.3049
0.0279 0.3605 0.3605
0.0901 1 1
0.024 0.9151 0.9151
0.0918 0.5578 1
0.0839 0.6293 0.6293
0.5371 1 1
0.5857 0.4831 0.4831
0.3862 1 1
0.0478 0.3238 0.3238
0.0835 0.3424 1
0.0228 0.6176 1
0.0675 0.2653 0.2586
0.1179 1 1
0.047 0.3636 0.7433
0.0675 0.7001 0.7988
0.1365 0.5049 0.7093
0.265 1 1
0.0234 0.4398 1
0.0105 0.3195 0.3195
0.0268 0.3094 1
0.0715 1 1
0.0486 1 0.5
0.0697 0.4245 1
0.0232 0.2777 0.7241
0.0237 0.2849 1
0.0205 0.3237 0.3292
0.0459 0.5 0.5
0.0696 1 1
0.0558 0.5619 1
0.0238 0.4004 0.4004
0.6833 0.4313 0.4313
0.0279 0.9838 0.9838
0.0279 0.384 0.8742
0.0254 0.3435 0.3401
0.1371 0.7238 1
0.0468 0.2624 1
0.1842 0.4074 1
0.0228 0.2546 0.2461
0.1236 1 1
0.3407 1 1
0.0279 0.2596 0.2596
0.0475 0.3944 0.3801
1.19028 1 1
0.0963 0.2593 1
0.0737 0.3063 0.3063
0.0279 0.3274 0.3272
0.0279 0.3663 0.3663
0.0254 0.3435 0.3401
0.0558 0.5 0.5
0.0456 0.4636 1
0.3281 0.2754 1
0.0235 0.2701 0.5043
0.0224 1 1
0.4887 1 1
0.0239 0.5543 0.6011
0.3281 0.2754 1
0.2362 0.395 1
0.0505 1 1
0.0279 1 1
0.0243 0.2521 0.5208
0.0492 0.4192 0.746
0.0225 0.2839 0.2839
0.6833 0.4313 0.4313
0.0952 1 1
0.0472 0.582 1
0.1198 1 1
0.1676 0.4378 1
0.0474 1 1
0.0091 0.995 0.5
0.0225 0.7632 1
0.1021 0.6772 0.6714
0.1061 1 1
0.0456 0.2632 1
0.5377 1 1
0.0232 0.2993 1
0.0464 0.519 1
0.0751 1 1
0.0741 1 1
0.0495 1 1
0.0733 0.5727 0.5727
0.021 0.4382 0.4382
0.0521 0.3564 0.3564
0.012 0.3186 0.3186
0.5758 0.3061 0.3061
0.0232 1 1
0.024 0.2746 0.739
0.0091 0.995 0.5
0.0662 0.2529 1
0.0362 0.6373 1
0.1416 0.2717 0.4623
0.0279 0.314 0.7536
0.4386 0.7428 1
0.0265 0.9363 0.9363
0.0697 1 0.5
0.0486 0.7193 1
0.4433 1 1
0.7965 0.328 0.328
0.1839 1 1
0.0279 1 1
0.0279 0.319 0.8049
0.3591 0.515 0.515
0.3589 1 1
0.3759 0.3292 0.3292
0.4386 0.3961 1
0.2878 1 1
0.0279 1 1
1.1931 1 1
0.1494 1 1
0.567 0.7023 0.9213
0.0229 0.3061 0.9931
0.5828 0.3055 0.3013
0.0279 1 0.5
0.0279 0.7262 1
0.2882 1 1
0.2814 1 1
0.0204 0.3602 0.3602
0.0675 0.7001 0.7988
0.0279 1 1
0.0279 0.9313 0.9299
0.0279 0.8282 1
0.0159 0.3259 0.3259
0.8094 0.3837 0.4566
0.0474 0.3043 0.3038
0.0263 0.4506 1
0.0480943 1 0.5
0.0939 0.6435 0.7332
0.0387 0.3125 0.3119
0.1172 1 1
0.0279 0.8225 1
0.024 0.9151 0.9151
0.07 0.7896 1
0.1183 0.4011 0.4011
0.0279 1 1
0.0422 1 0.5
0.1683 0.3703 0.3703
0.1626 0.3278 0.3277
0.0299 0.5595 0.6635
0.2145 1 1
0.0418 0.2603 1
0.2453 1 1
0.0397 1 1
0.3167 1 1
0.3799 1 1
0.3568 1 1
0.0279 0.3493 1
0.0709 0.4402 1
0.0279 1 1
0.0477 0.2932 0.2932
0.0449 0.4974 1
0.0471 1 1
0.0396 0.9991 1
0.0252 1 1
0.1731 1 1
0.0558 0.5 0.5
0.0227 0.5588 0.7502
0.2698 0.9819 1
0.0478 0.5439 1
0.0225 0.2699 0.359
0.1179 1 1
0.0224389 1 0.5
0.047 1 1
0.2959 1 1
0.1979 0.37 0.37
0.0279 0.8067 0.776
0.0279 0.6093 0.8721
0.0469 0.2594 1
0.0279 1 0.5
0.047 0.2658 1
0.0279 0.6555 1
0.1871 1 1
0.0279 0.4695 1
0.1692 0.7905 1
0.0279 0.9969 0.9969
0.3521 0.4531 1
0.0225 0.2659 0.5912
0.2455 1 1
0.045 1 0.5
0.0422 1 0.5
0.1441 1 1
0.0225 0.2733 0.8734
0.1394 1 1
0.0454 0.5412 1
0.0443 1 1
0.0688 0.6578 0.6557
0.0913 1 1
0.0224 0.3785 0.6009
0.0239 0.2736 1
0.0231 0.4442 1
0.0279 1 1
0.0504 0.6136 0.9931
0.0933 0.5823 0.5823
0.0229 0.5945 0.9363
0.0778 1 1
0.0254 0.3435 0.3401
0.1444 1 1
0.0453 0.4581 0.5227
0.0279 0.3235 0.7388
0.1365 0.5049 0.7093
0.3451 1 1
0.0839 0.6293 0.6293
0.6833 0.4313 0.4313
0.0467 0.5272 0.5261
0.0279 0.5 0.5
0.0238 0.2545 0.6634
0.1163 0.657 0.657
0.0227 0.2711 1
0.0279 1 1
0.0917 0.3615 1
0.1419 0.9869 1
0.4332 0.4867 0.4867
0.0224 0.2541 0.8832
0.0158 0.886 0.886
0.0279 0.845 0.8982
0.0279 0.3625 0.3598
0.3338 1 1
0.0279 1 1
0.7965 0.328 0.328
0.0241 0.2974 0.2974
0.51 1 1
0.2843 0.6935 1
0.0246 0.2774 0.3632
0.0243 0.716 0.9616
0.0279 0.5 0.5
0.0223 0.2836 0.7297
0.0478 1 1
0.5382 1 1
0.1979 0.37 0.37
0.2506 0.5873 1
0.3281 0.2754 1
0.0279 1 1
0.1179 1 1
0.0455 0.4912 0.4912
0.0279 0.5 0.5
0.0697 0.4245 1
0.0463 0.5493 1
0.2212 0.2768 0.2758
0.7965 0.328 0.328
0.0279 1 1
0.4714 1 1
1.4053 1 1
0.2843 0.6935 1
0.0279 0.4885 0.9119
0.7965 0.328 0.328
0.0957 0.9723 1
0.0232 0.273 0.542
0.0279 0.2872 0.5173
0.1957 1 1
0.0943 0.6186 0.6186
0.027 1 1
0.5382 1 1
0.2761 1 1
0.1391 1 1
0.0491 1 1
0.0241 0.2856 1
0.0936 0.7074 1
0.0232 0.2777 0.7241
0.0225 0.7378 0.7378
0.0443 1 1
0.0286 0.3122 0.3095
0.0463 0.5 0.5
0.2596 0.309 0.6943
0.2355 0.744 1
0.0688 0.6578 0.6557
0.0229 0.2851 0.2953
0.0558 0.5689 0.7889
0.2224 0.5598 0.5598
0.0265 0.3352 0.4245
0.2127 1 1
0.1901 1 1
0.3415 1 1
0.0964 0.9839 1
0.0091 0.2942 0.2942
0.1429 0.2632 0.3607
0.0695 0.4604 0.6067
0.0279 1 1
0.0939 0.2605 0.2604
0.4195 1 1
0.0692 1 1
0.0225 0.7378 0.7378
0.4566 1 1
0.2553 0.9629 1
0.0397 1 1
0.0269 1 1
0.1261 1 1
0.0472 0.6109 0.6109
0.3281 0.2754 1
0.0279 0.5 0.5
0.1009 0.337 0.3368
0.0143 1 1
0.0279 1 1
0.0965 1 1
0.0463 0.5493 1
0.0225 0.2596 0.2586
0.023 0.2584 0.8287
0.0461 0.5459 0.735
0.0459 0.4978 1
0.0458 1 1
0.0227 0.2939 0.702
0.2362 0.395 1
0.0232 0.2832 0.6161
0.2696 1 1
0.1399 0.5077 1
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0.0219108 0.430388 0.438074
0.0738 1 1
0.0494 0.4271 1
0.145 1 1
0.0225 0.487 0.487
0.0279 1 1
0.14 0.8695 1
0.0722 1 1
0.3428 1 1
0.2423 1 1
0.0746 1 0.5
0.0279 0.7844 1
0.0279 0.3029 0.5415
0.3281 0.2754 1
0.1421 0.5852 1
0.023 0.333 0.9629
0.045 1 1
0.0256 0.2832 0.2832
0.0227 0.2583 0.9154
0.0241 0.8007 0.8007
0.1262 1 1
0.0477 0.2932 0.2932
0.0471 0.3062 0.3062
0.3281 0.2754 1
0.0269 0.2925 0.3305
0.0257 0.3331 0.3321
1.1759 0.307 1
0.0926 0.9443 1
0.3281 0.2754 1
0.0279 0.312 0.5823
0.0147 0.257 0
0.503 1 1
0.0477 0.2932 0.2932
0.0238 0.359 0.5403
0.0143 0.324 0.324
0.6198 0.3061 0.3061
0.0346 0.4372 0.5557
0.0279 0.5 0.5
0.174 1 1
0.1416 0.2717 0.4623
0.0228 1 1
0.0225 0.2584 0.3891
0.0952 1 1
0.3762 1 1
1.4053 1 1
0.3115 1 1
0.0279 0.5862 1
0.0512 1 1
0.0279 0.3139 1
0.0301 0.3441 0.3441
0.1725 1 1
0.2249 0.8516 1
0.0279 0.3203 0.9254
0.0239 0.2964 1
0.2187 1 1
0.0349 0.3134 0.3134
0.5857 0.4831 0.4831
0.2007 0.3677 0.3676
0.0695 0.2673 0.2774
0.4386 0.3961 1
0.0426 1 1
0.169 0.8279 1
0.1448 0.9751 1
0.1421 1 0.5
0.1378 0.3507 0.3507
0.0226 0.5419 0.9591
0.1399 0.5077 1
0.0476 0.7282 1
0.4324 1 1
0.0279 0.3585 0.856
0.0558 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

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Gene identifier LOAG_03827 (Loa Loa (eye worm)), leukotriene A4 hydrolase
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