Detailed view for LOAG_11881

Basic information

TDR Targets ID: 950743
Loa Loa (eye worm), guanylate kinase
Source Database / ID:  KEGG  

pI: 6.7924 | Length (AA): 644 | MW (Da): 70945 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00018   SH3 domain
PF00595   PDZ domain (Also known as DHR or GLGF)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 33 4rp3 (A) 52 84 55.00 0 0.32 0.801742 -2.04
117 360 3gsl (A) 62 246 61.00 0 1 0.716282 0.51
271 360 2byg (A) 193 279 69.00 0 1 0.993152 -1.05
411 491 2vrf (A) 117 196 48.00 0.0000000015 1 0.807176 -1.43
525 606 3uat (A) 583 715 54.00 0 1 0.864729 -1.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128958)

Species Accession Gene Product
Brugia malayi Bm1_32060   Guanylate kinase family protein
Caenorhabditis elegans CELE_C25F6.2   Protein DLG-1, isoform B
Drosophila melanogaster Dmel_CG1725   discs large 1
Echinococcus granulosus EgrG_000247300   disks large 3
Echinococcus multilocularis EmuJ_000247300   disks large 3
Homo sapiens ENSG00000132535   discs, large homolog 4 (Drosophila)
Homo sapiens ENSG00000150672   discs, large homolog 2 (Drosophila)
Homo sapiens ENSG00000075711   discs, large homolog 1 (Drosophila)
Homo sapiens ENSG00000082458   discs, large homolog 3 (Drosophila)
Loa Loa (eye worm) LOAG_10443   lethal(1)discs large-1 tumor suppressor
Loa Loa (eye worm) LOAG_11881   guanylate kinase
Mus musculus ENSMUSG00000022770   discs, large homolog 1 (Drosophila)
Mus musculus 23859   discs, large homolog 2 (Drosophila)
Mus musculus ENSMUSG00000020886   discs, large homolog 4 (Drosophila)
Mus musculus ENSMUSG00000000881   discs, large homolog 3 (Drosophila)
Schistosoma japonicum Sjp_0113820   hypothetical protein
Schistosoma japonicum Sjp_0113810   IPR001452,Src homology-3;IPR001478,PDZ/DHR/GLGF,domain-containing
Schistosoma japonicum Sjp_0034200   Disks large homolog 4, putative
Schistosoma japonicum Sjp_0100400   hypothetical protein
Schistosoma japonicum Sjp_0034170   Disks large homolog 2, putative
Schistosoma mansoni Smp_170290   cell polarity protein
Schmidtea mediterranea mk4.015231.03  
Schmidtea mediterranea mk4.015231.01   Disks large 1 tumor suppressor protein
Schmidtea mediterranea mk4.002263.00   Disks large 1 tumor suppressor protein
Schmidtea mediterranea mk4.000837.00   Cell polarity protein
Schmidtea mediterranea mk4.003153.01   Cell polarity protein
Schmidtea mediterranea mk4.025248.00   Disks large 1 tumor suppressor protein

Essentiality

LOAG_11881 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C25F6.2 Caenorhabditis elegans embryonic arrest wormbase
CELE_C25F6.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C25F6.2 Caenorhabditis elegans larval arrest wormbase
CELE_C25F6.2 Caenorhabditis elegans larval lethal wormbase
CELE_C25F6.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens discs, large homolog 4 (Drosophila) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0043 0.6464 0.8126
0.0282 0.283 0.4202
0.0518 0.522 0.522
0.0048 0.281 0.281
0.0544 0.5423 0.8237
0.0122 0.2695 0.3821
0.0126 0.624 0.7358
0.0059 0.3 0.3006
0.0039 0.2713 0.2713
0.0065 0.3464 0.32
0.0024 0.624 0
0.0137 0.2846 0.2741
0.0075 0.2576 0.2576
0.00394418 0.278418 0.262031
0.0137 0.3036 0.3036
0.0167 0.4749 0
0.0046 0.6464 0.8126
0.0322685 0.273741 0.262341
0.0062 0.624 0.67
0.006 0.3204 0.3204
0.0282 0.283 0.4202
0.0065 0.3464 0.32
0.00394418 0.278418 0.262031
0.0068 0.2794 0.2794
0.0111 0.7388 0.8703
0.0048 0.3625 0.3625
0.0267 0.5328 0.8748
0.0029 0.4037 0.4037
0.0481 0.4738 0.5539
0.0061 1 1
0.0024 0.624 0
0.0351989 0.270507 0.26116
0.0029 0.4037 0.4037
0.0126 0.624 0.7358
0.0336199 0.276589 0.265254
0.0378 0.315 0.3101
0.0027 0.3179 0.3179
0.0039 0.2713 0.2713
0.0027 0.3179 0.3179
0.0064 0.3347 0.3362

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LOAG_11881 (Loa Loa (eye worm)), guanylate kinase
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