Detailed view for LOAG_09895

Basic information

TDR Targets ID: 950746
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 8.0587 | Length (AA): 774 | MW (Da): 88369 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02460   Patched family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 309 4haw (C) 578 877 11.00 0 0.07 0.463873 -0.07
62 280 5f18 (A) 13 230 20.00 0 0.91 0.361346 0.35
311 360 5ctg (A) 49 94 37.00 0.88 0.04 0.0743995 2.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130495)

Species Accession Gene Product
Brugia malayi Bm1_55630   Patched family protein
Caenorhabditis elegans CELE_C32E8.8   Protein PTR-2
Caenorhabditis elegans CELE_F55F8.1   Protein PTR-10
Caenorhabditis elegans CELE_Y39A1B.2   Protein PTR-19, isoform A
Cryptosporidium hominis Chro.70104   patched family protein
Cryptosporidium hominis Chro.20466   F55F8.1
Cryptosporidium parvum cgd2_4350   putative patched family protein with 12 transmembrane domain
Cryptosporidium parvum cgd7_850   putative patched family protein
Drosophila melanogaster Dmel_CG11212   Patched-related
Homo sapiens ENSG00000182077   patched domain containing 3
Loa Loa (eye worm) LOAG_13222   hypothetical protein
Loa Loa (eye worm) LOAG_00748   hypothetical protein
Loa Loa (eye worm) LOAG_09895   hypothetical protein
Mus musculus ENSMUSG00000039198   patched domain containing 3
Neospora caninum NCLIV_001860   Sterol sensing 5-transmembrane protein, related
Neospora caninum NCLIV_042740   patched family domain-containing protein, conserved, putative
Plasmodium berghei PBANKA_0205900   lipid/sterol:H+ symporter, putative
Plasmodium falciparum PF3D7_0107500   lipid/sterol:H+ symporter
Plasmodium knowlesi PKNH_0206100   patched family protein, putative
Plasmodium vivax PVX_081400   patched family protein, putative
Plasmodium yoelii PY03953   Drosophila melanogaster CG11212 gene product
Toxoplasma gondii TGME49_290870   patched family protein
Toxoplasma gondii TGME49_295015   patched family protein

Essentiality

LOAG_09895 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C32E8.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_C32E8.8 Caenorhabditis elegans larval arrest wormbase
CELE_C32E8.8 Caenorhabditis elegans slow growth wormbase
PBANKA_0205900 Plasmodium berghei Essential plasmo
TGME49_290870 Toxoplasma gondii Probably non-essential sidik
TGME49_295015 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_09895 (Loa Loa (eye worm)), hypothetical protein
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