Detailed view for LOAG_02841

Basic information

TDR Targets ID: 951292
Loa Loa (eye worm), hypothetical protein

Source Database / ID:  KEGG  

pI: 6.5337 | Length (AA): 573 | MW (Da): 66636 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF00038   Intermediate filament protein
PF00932   Lamin Tail Domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005882   intermediate filament  
GO:0005198   structural molecule activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
146 395 5xg2 (A) 346 811 19.00 0 1 0.5969 -0.47
175 401 5cwp (A) 3 222 18.00 0 0.33 0.582761 -1.14
349 418 1gk6 (A) 358 409 50.00 0.62 0.17 0.043864 1.03
460 573 2lll (A) 449 562 38.00 0 1 0.656553 -1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128723)

Species Accession Gene Product
Brugia malayi Bm1_45215   intermediate filament protein
Brugia malayi Bm1_49730   Intermediate filament tail domain containing protein
Caenorhabditis elegans CELE_F38B2.1   Protein IFA-1, isoform C
Caenorhabditis elegans CELE_DY3.2   Protein LMN-1
Caenorhabditis elegans CELE_F52E10.5   Protein IFA-3
Caenorhabditis elegans CELE_W10G6.3   Protein MUA-6
Caenorhabditis elegans CELE_K05B2.3   Protein IFA-4
Dictyostelium discoideum DDB_G0289429   hypothetical protein
Drosophila melanogaster Dmel_CG10119   Lamin C
Drosophila melanogaster Dmel_CG6944   Lamin
Echinococcus granulosus EgrG_000858200   intermediate filament protein
Echinococcus granulosus EgrG_000973400   lamin
Echinococcus granulosus EgrG_000973500   lamin dm0
Echinococcus granulosus EgrG_000116400   cytoplasmic intermediate filament protein
Echinococcus multilocularis EmuJ_000116400   cytoplasmic intermediate filament protein
Echinococcus multilocularis EmuJ_000858200   musashi
Echinococcus multilocularis EmuJ_000973500   lamin dm0
Echinococcus multilocularis EmuJ_000973400   lamin
Homo sapiens ENSG00000176619   lamin B2
Homo sapiens ENSG00000160789   lamin A/C
Homo sapiens ENSG00000113368   lamin B1
Loa Loa (eye worm) LOAG_01478   intermediate filament protein
Loa Loa (eye worm) LOAG_13960   hypothetical protein
Loa Loa (eye worm) LOAG_09525   intermediate filament tail domain-containing protein
Loa Loa (eye worm) LOAG_13492   hypothetical protein
Loa Loa (eye worm) LOAG_15388   hypothetical protein
Loa Loa (eye worm) LOAG_02841 this record   hypothetical protein
Loa Loa (eye worm) LOAG_13714   hypothetical protein
Mus musculus ENSMUSG00000028063   lamin A
Mus musculus ENSMUSG00000024590   lamin B1
Mus musculus ENSMUSG00000062075   lamin B2
Onchocerca volvulus OVOC9475  
Onchocerca volvulus OVOC8446  
Schistosoma japonicum Sjp_0317460   expressed protein
Schistosoma japonicum Sjp_0002570   Intermediate filament protein ifa-1, putative
Schistosoma japonicum Sjp_0092100   Lamin-C, putative
Schistosoma japonicum Sjp_0089760   expressed protein
Schistosoma japonicum Sjp_0092110   ko:K07611 lamin, putative
Schistosoma mansoni Smp_159900.1   lamin
Schistosoma mansoni Smp_170930   intermediate filament proteins
Schistosoma mansoni Smp_159900.2   lamin
Schmidtea mediterranea mk4.035995.00   Putative intermediate filament proteins
Schmidtea mediterranea mk4.004533.00   Putative intermediate filament proteins
Schmidtea mediterranea mk4.015738.04  
Schmidtea mediterranea mk4.001248.05  
Schmidtea mediterranea mk4.001239.05  
Schmidtea mediterranea mk4.002268.08  
Schmidtea mediterranea mk4.018020.00   Putative intermediate filament proteins
Schmidtea mediterranea mk4.000135.15  
Schmidtea mediterranea mk4.015738.02  
Schmidtea mediterranea mk4.015738.03  
Schmidtea mediterranea mk4.001379.07   Lamin-1
Schmidtea mediterranea mk4.004533.05   Putative intermediate filament proteins

Essentiality

LOAG_02841 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F38B2.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F38B2.1 Caenorhabditis elegans larval arrest wormbase
CELE_F38B2.1 Caenorhabditis elegans larval lethal wormbase
CELE_F38B2.1 Caenorhabditis elegans slow growth wormbase
CELE_F52E10.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_F52E10.5 Caenorhabditis elegans larval arrest wormbase
CELE_F52E10.5 Caenorhabditis elegans larval lethal wormbase
CELE_F52E10.5 Caenorhabditis elegans slow growth wormbase
CELE_DY3.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_DY3.2 Caenorhabditis elegans larval lethal wormbase
CELE_DY3.2 Caenorhabditis elegans sterile wormbase
CELE_W10G6.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_W10G6.3 Caenorhabditis elegans larval arrest wormbase
CELE_W10G6.3 Caenorhabditis elegans larval lethal wormbase
CELE_W10G6.3 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens lamin A/C Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0033 0.4263 0.4263
0.0026 0.2628 0.2628
0.0033 0.387 0.387
0.0033 0.3647 0.3647
0.0033 0.2925 0.4263
0.0033 0.2925 1
0.0033 0.4536 0.4536
0.0033 0.2772 0.2772
0.0027 0.9924 0.9922
0.0027 0.2772 0.2772
0.0059 0.2828 0.2696
0.0026 0.309 0.3603
0.0033 0.4456 0.4456
0.0028 0.2561 0.2561
0.0033 0.4263 0.4263
0.0031 0.3645 0.3645
0.0033 0.3537 0.3537
0.0054 0.3977 0.3977
0.0033 0.3537 0.3537
0.0033 0.7011 1
0.0033 0.2704 0.3014
0.0028 0.3537 0.3537
0.0027 0.3556 0.3556
0.0059 0.504 0.504
0.0033 0.2927 0.3104
0.0033 0.2706 1
0.0033 0.3072 0.343
0.0033 0.3348 0.3348
0.0033 0.3537 0.3537
0.0029 0.4071 0.9853
0.003 0.4145 0.4145
0.0026 0.2772 0.2772
0.0024 0.4238 1
0.0033 0.3537 0.3537
0.0061 0.8069 0.9111
0.0033 0.4263 0.4263
0.0033 0.4274 0.4274
0.0033 0.3537 0.3537
0.0033 0.3537 0.3537
0.0923 0.2974 0.5273
0.0033 0.2772 0.2772
0.0142 0.3455 0.3455
0.0033 0.2997 1
0.0827 0.4777 0.4862
0.0033 0.3537 0.3537
0.0033 0.5815 1
0.008 0.5969 0.5969
0.0146 0.3796 0.4533
0.0033 0.6159 1
0.0028 0.3537 0.3537
0.0055 0.3426 0.3426
0.0031 0.3537 0.3537
0.0033 0.2772 0.2772
0.0027 0.5815 1
0.0033 0.5815 1
0.0056 0.807 1
0.0033 0.3615 1
0.003 0.2925 1
0.0059 0.3066 0.3066
0.0033 0.4349 0.4349
0.0033 0.5815 1
0.0033 0.2925 1
0.0031 0.4263 0.4263
0.0033 0.2849 0.2849
0.0031 0.3702 0.3702
0.0027 0.3447 0.2939
0.0029 0.3338 0.3338
0.0033 0.3788 0.3788
0.0033 0.6859 0.6859
0.0029 0.8055 0.8055
0.0912 0.4899 0.4899
0.0033 0.4349 0.4349
0.0028 0.3271 0.3271
0.0033 0.3537 0.3537
0.0033 0.3959 0.3959
0.0029 0.5782 1
0.0033 0.2842 0.2842
0.0033 0.4263 0.4263
0.0033 0.4263 0.4263
0.0033 0.3788 0.3788
0.0033 0.4263 0.4263
0.0032 0.5369 0.5369
0.0059 0.3526 0.3526
0.0029 0.2626 0.2882
0.0029 0.2997 1
0.0033 0.5349 0.5349
0.0029 0.4088 0.4444
0.0031 0.2997 1
0.0033 0.4263 0.4263
0.0028 0.4263 0.4263
0.0033 0.8364 0.8364
0.0031 0.2772 0.2772
0.0028 0.593 0.593
0.0032 0.5369 0.5369
0.0033 0.5086 0.5086
0.0027 0.9924 0.9922
0.0033 0.4773 0.4773
0.0026 0.4001 0.4001
0.0317 0.3895 0.6635
0.0026 0.3548 0.7351
0.0032 0.2951 1
0.003 0.5048 0.9545
0.0029 0.5815 1
0.0139 0.3641 0.3679
0.023 0.557 0.9295
0.0033 0.4263 0.4263

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_02841 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment