Detailed view for MUL_0073

Basic information

TDR Targets ID: 951509
Mycobacterium ulcerans, 30S ribosomal protein S18
Source Database / ID:  KEGG  

pI: 11.2785 | Length (AA): 84 | MW (Da): 9542 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01084   Ribosomal protein S18

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 83 2vqe (R) 16 85 36.00 0 0.92 1.28403 -0.16
31 80 1g1x (C) 33 82 37.00 0.0000022 0.64 0.825438 0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128626)

Species Accession Gene Product
Arabidopsis thaliana ArthCp044   30S ribosomal protein S18
Brugia malayi Bm1_27350   hypothetical protein
Candida albicans CaO19.12668   similar to S. cerevisiae RSM18 (YER050C) mitochondrial ribosome small subunit protein S18
Candida albicans CaO19.5201   similar to S. cerevisiae RSM18 (YER050C) mitochondrial ribosome small subunit protein S18
Caenorhabditis elegans CELE_T14B4.2   Protein T14B4.2
Chlamydia trachomatis CT_802   30S ribosomal protein S18
Dictyostelium discoideum DDB_G0269762   hypothetical protein
Drosophila melanogaster Dmel_CG9688   mitochondrial ribosomal protein S18C
Escherichia coli b4202   30S ribosomal subunit protein S18
Echinococcus granulosus EgrG_000575400   28S ribosomal protein S18c mitochondrial
Echinococcus multilocularis EmuJ_000575400   28S ribosomal protein S18c, mitochondrial
Homo sapiens 51023   mitochondrial ribosomal protein S18C
Loa Loa (eye worm) LOAG_06626   hypothetical protein
Mycobacterium leprae ML2683c   PROBABLE 30S RIBOSOMAL PROTEIN S18-1 RPSR
Mus musculus 68735   mitochondrial ribosomal protein S18C
Mus musculus 100502686   predicted gene 15946
Mycobacterium tuberculosis Rv0055   30S ribosomal protein S18-1 RpsR1
Mycobacterium tuberculosis Rv2055c   30S ribosomal protein S18 RpsR2
Mycobacterium ulcerans MUL_0073   30S ribosomal protein S18
Mycobacterium ulcerans MUL_4834   30S ribosomal protein S18
Oryza sativa 3131440   ribosomal protein S18
Onchocerca volvulus OVOC5705   28S ribosomal protein S18c, mitochondrial homolog
Saccharomyces cerevisiae YER050C   mitochondrial 37S ribosomal protein RSM18
Schistosoma japonicum Sjp_0202580   28S ribosomal protein S18c, mitochondrial precursor, putative
Schistosoma mansoni Smp_027240   hypothetical protein
Schmidtea mediterranea mk4.002779.04   28S ribosomal protein S18c, mitochondrial
Schmidtea mediterranea mk4.003064.00   28S ribosomal protein S18c, mitochondrial
Treponema pallidum TP0061   30S ribosomal protein S18
Wolbachia endosymbiont of Brugia malayi Wbm0501   30S ribosomal protein S18

Essentiality

MUL_0073 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2087 Mycobacterium tuberculosis non-essential nmpdr
b4202 Escherichia coli essential goodall
CELE_T14B4.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_T14B4.2 Caenorhabditis elegans larval arrest wormbase
CELE_T14B4.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_0073 (Mycobacterium ulcerans), 30S ribosomal protein S18
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