pI: 6.0706 |
Length (AA): 385 |
MW (Da): 40377 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 380 | 4rqt (A) | 8 | 375 | 34.00 | 0 | 1 | 1.37481 | -0.16 |
1 | 385 | 3two (A) | 3 | 346 | 22.00 | 0 | 1 | 1.1405 | 0.15 |
1 | 382 | 2jhf (A) | 7 | 374 | 34.00 | 0 | 1 | 1.40001 | -0.16 |
18 | 286 | 2xaa (A) | 12 | 262 | 38.00 | 0 | 1 | 0.845501 | 1.25 |
190 | 314 | 3e05 (A) | 240 | 365 | 18.00 | 0 | 0.95 | 0.530175 | -0.39 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127257)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G77120 | alcohol dehydrogenase 1 |
Arabidopsis thaliana | AT5G43940 | alcohol dehydrogenase class-3 |
Arabidopsis thaliana | AT5G63620 | GroES-like zinc-binding alcohol dehydrogenase family protein |
Brugia malayi | Bm1_52445 | Alcohol dehydrogenase class III |
Candida albicans | CaO19.7600 | similar to C termini of C.maltosa FDH1 and S. cerevisiae SFA1 (YDL168W) glutathione-dependent formaldehyde dehydrogenase, long-c |
Caenorhabditis elegans | CELE_H24K24.3 | Protein H24K24.3, isoform B |
Caenorhabditis elegans | CELE_Y50D4C.2 | Protein Y50D4C.2 |
Dictyostelium discoideum | DDB_G0281865 | alcohol dehydrogenase, class 3 |
Drosophila melanogaster | Dmel_CG6598 | Formaldehyde dehydrogenase |
Escherichia coli | b0356 | alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase |
Homo sapiens | ENSG00000187758 | alcohol dehydrogenase 1A (class I), alpha polypeptide |
Homo sapiens | ENSG00000196616 | alcohol dehydrogenase 1B (class I), beta polypeptide |
Homo sapiens | ENSG00000197894 | alcohol dehydrogenase 5 (class III), chi polypeptide |
Homo sapiens | ENSG00000248144 | alcohol dehydrogenase 1C (class I), gamma polypeptide |
Loa Loa (eye worm) | LOAG_03095 | alcohol dehydrogenase class III |
Mycobacterium leprae | ML1784 | Probable S-nitrosomycothiol reductase MscR |
Mus musculus | 100417514 | alcohol dehydrogenase 6B (class V) |
Mus musculus | ENSMUSG00000053054 | alcohol dehydrogenase 6A (class V) |
Mus musculus | ENSMUSG00000074207 | alcohol dehydrogenase 1 (class I) |
Mus musculus | ENSMUSG00000028138 | alcohol dehydrogenase 5 (class III), chi polypeptide |
Mycobacterium tuberculosis | Rv3086 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) |
Mycobacterium tuberculosis | Rv0761c | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB |
Mycobacterium tuberculosis | Rv0162c | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 |
Mycobacterium ulcerans | MUL_4872 | zinc-type alcohol dehydrogenase AdhD |
Mycobacterium ulcerans | MUL_1292 | zinc-dependent alcohol dehydrogenase AdhE2 |
Mycobacterium ulcerans | MUL_3861 | zinc-containing alcohol dehydrogenase NAD dependent AdhB |
Mycobacterium ulcerans | MUL_0470 | zinc-containing alcohol dehydrogenase NAD-dependent AdhB |
Mycobacterium ulcerans | MUL_4777 | zinc-dependent alcohol dehydrogenase |
Neospora caninum | NCLIV_055560 | alcohol dehydrogenase class III, putative |
Oryza sativa | 4344469 | Os08g0109200 |
Oryza sativa | 4350053 | Os11g0210300 |
Oryza sativa | 4331130 | Os02g0815500 |
Oryza sativa | 4350054 | Os11g0210500 |
Onchocerca volvulus | OVOC6614 | Putative alcohol dehydrogenase |
Saccharomyces cerevisiae | YDL168W | bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase |
Schistosoma japonicum | Sjp_0102900 | Alcohol dehydrogenase class-3, putative |
Schistosoma japonicum | Sjp_0101110 | Alcohol dehydrogenase class-3, putative |
Schistosoma japonicum | Sjp_0313140 | ko:K00001 alcohol dehydrogenase [EC1.1.1.1], putative |
Schistosoma mansoni | Smp_044440 | alcohol dehydrogenase |
Schmidtea mediterranea | mk4.001010.01 | Putative alcohol dehydrogenase |
Toxoplasma gondii | TGME49_311780 | Zn-containing alcohol dehydrogenase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3139 | Mycobacterium tuberculosis | non-essential | nmpdr |
b0356 | Escherichia coli | non-essential | goodall |
TGME49_311780 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | alcohol dehydrogenase 1A (class I), alpha polypeptide | Compounds | References |
Equus caballus | Alcohol dehydrogenase | Compounds | References |
Homo sapiens | alcohol dehydrogenase 1C (class I), gamma polypeptide | Compounds | References |
Homo sapiens | alcohol dehydrogenase 1B (class I), beta polypeptide | Compounds | References |
Homo sapiens | alcohol dehydrogenase 5 (class III), chi polypeptide | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Sorbitol dehydrogenase | 357 aa | 25.8% | 353 aa | Compounds | References |