pI: 9.6168 |
Length (AA): 501 |
MW (Da): 55370 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 499 | 1ukc (A) | 23 | 534 | 24.00 | 0 | 1 | 1.24381 | -0.15 |
4 | 494 | 2ogs (A) | 3 | 495 | 36.00 | 0 | 1 | 1.37674 | -0.34 |
29 | 480 | 6emi (A) | 31 | 507 | 34.00 | 0 | 1 | 1.2259 | -0.11 |
85 | 211 | 4ypv (A) | 63 | 177 | 35.00 | 0.000000028 | 1 | 0.544193 | -0.68 |
100 | 139 | 2zsh (A) | 106 | 148 | 53.00 | 0.065 | 0.13 | 0.29254 | 1.43 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127908)
Species | Accession | Gene Product |
---|---|---|
Caenorhabditis elegans | CELE_R12A1.4 | Protein GES-1 |
Dictyostelium discoideum | DDB_G0285555 | hypothetical protein |
Dictyostelium discoideum | DDB_G0283085 | hypothetical protein |
Dictyostelium discoideum | DDB_G0276969 | hypothetical protein |
Dictyostelium discoideum | DDB_G0285419 | crystal protein |
Drosophila melanogaster | Dmel_CG3841 | CG3841 gene product from transcript CG3841-RB |
Drosophila melanogaster | Dmel_CG6414 | CG6414 gene product from transcript CG6414-RA |
Homo sapiens | ENSG00000198848 | carboxylesterase 1 |
Homo sapiens | ENSG00000172831 | carboxylesterase 2 |
Homo sapiens | 100653057 | liver carboxylesterase 1-like |
Mus musculus | ENSMUSG00000057400 | carboxylesterase 1C |
Mus musculus | ENSMUSG00000061825 | carboxylesterase 2C |
Mus musculus | ENSMUSG00000071047 | carboxylesterase 1A |
Mus musculus | ENSMUSG00000078964 | carboxylesterase 1B |
Mus musculus | 75704 | carboxylesterase 1H |
Mus musculus | ENSMUSG00000091813 | carboxylesterase 2H |
Mus musculus | ENSMUSG00000050097 | carboxyesterase 2B |
Mus musculus | ENSMUSG00000031886 | carboxylesterase 2E |
Mus musculus | ENSMUSG00000031877 | carboxylesterase 2G |
Mus musculus | ensembl-mmu:ENSMUSG00000056973 | carboxylesterase 1D |
Mus musculus | ENSMUSG00000031725 | carboxylesterase 1F |
Mus musculus | ENSMUSG00000062826 | carboxylesterase 2F |
Mus musculus | ENSMUSG00000061959 | carboxylesterase 1E |
Mus musculus | ENSMUSG00000055730 | carboxylesterase 2A |
Mus musculus | ENSMUSG00000057074 | carboxylesterase 1G |
Mycobacterium tuberculosis | Rv2045c | Carboxylesterase LipT |
Mycobacterium ulcerans | MUL_2261 | carboxylesterase, LipT |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | carboxylesterase 2 | Compounds | References |
Rattus norvegicus | Liver carboxylesterase B-1 | Compounds | References |
Oryctolagus cuniculus | Acyl coenzyme A:cholesterol acyltransferase | Compounds | References |
Mus musculus | carboxylesterase 2C | Compounds | References |
Sus scrofa | Carboxylesterase | Compounds | References |
Mus musculus | carboxylesterase 1D | Compounds | References |
Homo sapiens | carboxylesterase 1 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Laodelphax striatella | Acetylcholinesterase | 426 aa | 32.2% | 376 aa | Compounds | References |