Detailed view for MUL_2173

Basic information

TDR Targets ID: 952221
Mycobacterium ulcerans, 3-ketoacyl-ACP reductase
Source Database / ID:  KEGG  

pI: 5.2854 | Length (AA): 260 | MW (Da): 26883 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13561   Enoyl-(Acyl carrier protein) reductase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 259 3e03 (A) 2 265 28.00 0 1 1.18526 0.05
4 243 1k2w (A) 1 252 34.00 0 1 1.35388 -0.63
4 247 4egf (A) 12 262 40.00 0 1 1.44886 -0.64
10 205 3h7a (A) 7 231 22.00 0.0000067 1 1.12325 -0.93
10 64 2z5l (A) 240 294 44.00 0.34 1 0.738938 -0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129079)

Species Accession Gene Product
Arabidopsis thaliana AT4G05530   short-chain dehydrogenase/reductase A
Arabidopsis thaliana AT2G29260   NAD(P)-binding Rossmann-fold superfamily protein
Caenorhabditis elegans CELE_F36H9.3   Protein DHS-13
Caenorhabditis elegans CELE_F54F3.4   Protein F54F3.4
Drosophila melanogaster Dmel_CG10672   CG10672 gene product from transcript CG10672-RA
Homo sapiens ENSG00000157326   dehydrogenase/reductase (SDR family) member 4
Mus musculus ENSMUSG00000022209   dehydrogenase/reductase member 2
Mus musculus ENSMUSG00000022210   dehydrogenase/reductase (SDR family) member 4
Mycobacterium tuberculosis Rv2766c   Probable short-chain type dehydrogenase/reductase
Mycobacterium ulcerans MUL_2481   short-chain type dehydrogenase/reductase
Mycobacterium ulcerans MUL_2173   3-ketoacyl-ACP reductase
Mycobacterium ulcerans MUL_4384   short-chain type dehydrogenase/reductase
Oryza sativa 4346459   Os09g0133200
Schmidtea mediterranea mk4.006996.01  
Schmidtea mediterranea mk4.007177.00  

Essentiality

MUL_2173 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2813 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Cochliobolus lunatus 17-beta-hydroxysteroid-dehydrogenase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus (strain NCTC 8325) Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI 256 aa 27.2% 261 aa Compounds References
Staphylococcus aureus Enoyl-[acyl-carrier-protein] reductase [NADPH] 256 aa 27.6% 261 aa Compounds References
Macaca mulatta Hydroxysteroid 11-beta dehydrogenase 1 140 aa 30.9% 136 aa Compounds References
Staphylococcus aureus subsp. aureus MRSA252 Enoyl-[acyl-carrier-protein] reductase 256 aa 27.6% 261 aa Compounds References
Bacillus subtilis (strain 168) Enoyl-[acyl-carrier-protein] reductase [NADH] 258 aa 24.6% 260 aa Compounds References
Staphylococcus aureus Enoyl-ACP reductase 243 aa 27.3% 245 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.021 0.8716 0
0.0226 0.2793 0.9606
0.0226 0.2793 0.9606
0.0212 0.2867 0.9604
0.0226 0.2806 0.9606
0.0103 0.9613 0.9613
0.0209 0.2781 0.6989
0.0207 0.2784 0.9603
0.0124 0.3213 0.9409
0.0256 0.3131 0
0.013 0.8847 0.8746
0.0243 0.9572 0
0.0212 0.5858 0.9613
0.0026 0.3431 0.3479
0.0256 0.3131 0
0.01 0.9598 0.9566
0.0133 0.8786 0.8782
0.0223 0.7904 0.9161
0.0124 0.9598 0.9566
0.0124 0.9598 0.9566
0.0211 0.2784 0.9606
0.0223 0.3055 0.7307
0.0076 0.3786 0.8413
0.0184 0.9309 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_2173 (Mycobacterium ulcerans), 3-ketoacyl-ACP reductase
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