pI: 6.1581 |
Length (AA): 637 |
MW (Da): 67830 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 628 | 2o1x (A) | 12 | 626 | 40.00 | 0 | 1 | 1.39017 | -0.16 |
316 | 577 | 1umd (B) | 6 | 280 | 23.00 | 0 | 1 | 0.677203 | -0.49 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129068)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G11380 | 1-deoxy-D-xylulose 5-phosphate synthase 3 |
Arabidopsis thaliana | AT4G15560 | 1-deoxy-D-xylulose-5-phosphate synthase |
Arabidopsis thaliana | AT3G21500 | 1-deoxy-D-xylulose 5-phosphate synthase 1 |
Babesia bovis | BBOV_III002600 | 1-deoxy-D-xylulose-5-phosphate synthase family protein |
Chlamydia trachomatis | CT_331 | 1-deoxy-D-xylulose-5-phosphate synthase |
Escherichia coli | b0420 | 1-deoxyxylulose-5-phosphate synthase, thiamine triphosphate-binding, FAD-requiring |
Mycobacterium leprae | ML1038 | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) |
Mycobacterium tuberculosis | Rv2682c | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) |
Mycobacterium ulcerans | MUL_3319 | 1-deoxy-D-xylulose-5-phosphate synthase |
Neospora caninum | NCLIV_003330 | hypothetical protein |
Oryza sativa | 4338768 | Os05g0408900 |
Oryza sativa | 4342614 | Os07g0190000 |
Oryza sativa | 4340090 | Os06g0142900 |
Plasmodium berghei | PBANKA_1351000 | 1-deoxy-D-xylulose 5-phosphate synthase, putative |
Plasmodium falciparum | PF3D7_1337200 | 1-deoxy-D-xylulose 5-phosphate synthase |
Plasmodium knowlesi | PKNH_1264100 | 1-deoxy-D-xylulose 5-phosphate synthase, putative |
Plasmodium vivax | PVX_082790 | 1-deoxy-D-xylulose 5-phosphate synthase, putative |
Plasmodium yoelii | PY04970 | unnamed protein product-related |
Schmidtea mediterranea | mk4.046580.01 | |
Toxoplasma gondii | TGME49_208820 | 1-deoxy-D-xylulose-5-phosphate synthase |
Treponema pallidum | TP0824 | 1-deoxy-D-xylulose-5-phosphate synthase |
Theileria parva | TP01_0516 | 1-deoxy-D-xylulose 5-phosphate synthase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2728 | Mycobacterium tuberculosis | essential | nmpdr |
b0420 | Escherichia coli | essential | goodall |
TGME49_208820 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Haemophilus influenzae (strain 86-028NP) | 1-deoxy-D-xylulose-5-phosphate synthase | Compounds | References |
Escherichia coli | 1-deoxyxylulose-5-phosphate synthase, thiamine triphosphate-binding, FAD-requiring | Compounds | References |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | Compounds | References |
Arabidopsis thaliana | 1-deoxy-D-xylulose-5-phosphate synthase | Compounds | References |
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 /LMG 4051 / NBRC 15346 / NCIMB 92 | 1-deoxy-D-xylulose-5-phosphate synthase | Compounds | References |