Detailed view for MUL_2955

Basic information

TDR Targets ID: 953384
Mycobacterium ulcerans, fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT
Source Database / ID:  KEGG  

pI: 9.6772 | Length (AA): 981 | MW (Da): 107673 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00083   Sugar (and other) transporter
PF00872   Transposase, Mutator family
PF07690   Major Facilitator Superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0006313   transposition, DNA-mediated  
GO:0016021   integral to membrane  
GO:0003677   DNA binding  
GO:0004803   transposase activity  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
642 816 4q65 (A) 7 185 13.00 0.00017 0.11 0.309989 -0.26
659 843 4he8 (N) 196 399 30.00 0.72 0.56 0.364983 -0.06
681 819 4yb9 (D) 68 208 32.00 0.0000007 0.45 0.308092 0.93
859 965 1v60 (A) 20 128 16.00 0.087 0.02 0.142672 -0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129134)

Species Accession Gene Product
Candida albicans CaO19.12767   one of two genes similar to S. cerevisiae JEN1 (YKL217W) lactate and pyruvate transporter
Candida albicans CaO19.7447   one of two genes similar to S. cerevisiae JEN1 (YKL217W) lactate and pyruvate transporter
Candida albicans CaO19.5307   one of two genes similar to S. cerevisiae JEN1 (YKL217W) lactate and pyruvate transporter
Escherichia coli b4279   putative transporter
Escherichia coli b3224   sialic acid transporter
Mycobacterium tuberculosis Rv1902c   Probable sialic acid-transport integral membrane protein NanT
Mycobacterium ulcerans MUL_2955   fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT
Oryza sativa 4331945   Os03g0197100
Saccharomyces cerevisiae YKL217W   Jen1p
Schmidtea mediterranea mk4.075043.00  

Essentiality

MUL_2955 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3224 Escherichia coli non-essential goodall
b4279 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.038 0.5 0.5
0.0862 0.3709 1
0.0893 0.3833 0.5
0.0215 1 1
0.0731 0.6098 1
0.0778 0.2723 0.5
0.0801 0.3587 0.5
0.0882 0.383 0.5
0.0604 0.5795 0.5
0.0839 0.3687 0.5
0.0883 0.4017 0.5
0.0938 0.3795 0.5
0.0908 0.4056 1
0.0906 0.3708 0.5
0.0934 0.355 1
0.0757 0.2571 1
0.086 0.4118 1
0.0849 0.3822 0.5
0.0785 0.3546 1
0.089 0.2727 1
0.001 0.5 0.5
0.0026 0.4542 0.5
0.0911 0.3866 0.5
0.0931 0.4131 0.5
0.092 0.3639 0.5
0.0705 0.673 0.5
0.0766 0.3381 1
0.0691 0.6563 0.5
0.0881 0.4196 1
0.082 0.3993 1
0.0115 0.8254 0.5
0.0705 0.2788 0.5
0.001 0.5 0.5
0.0006 0.5 0.5
0.0789 0.351 1
0.0858 0.3951 0.5
0.0708 0.6913 1
0.0858 0.401 0.5
0.0771 0.3215 0.5
0.0778 0.2723 0.5
0.0692 0.2863 0.5
0.0919 0.4066 0.5
0.0786 0.3708 0.5
0.0006 0.5 0.5
0.0851 0.3655 1
0.0218 0.2749 1
0.0731 0.7159 1
0.0788 0.3469 0.5
0.0649 0.5 0.5
0.0815 0.3701 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0725 0.3007 0.5
0.0152 0.339 0.5
0.0372 0.3723 0.5
0.0026 0.5 0.5
0.0943 0.4376 1
0.0699 0.3137 1
0.08 0.3562 1
0.0242 1 0.5
0.0006 0.5 0.5
0.0052 0.3137 0.4731
0.0859 0.3889 0.5
0.0731 0.7159 1
0.0676 0.4278 1
0.0026 0.5 0.5
0.0945 0.3769 0.5
0.0761 0.7227 0.5
0.0872 0.3682 0.5
0.0636 0.5945 0.5
0.0801 0.3419 1
0.0911 0.3937 1
0.0737 0.7131 0.5
0.09 0.368 0.5
0.0909 0.3804 0.5
0.0825 0.381 0.5
0.0395 0.4327 0.5
0.088 0.3774 0.5
0.0869 0.3805 0.5
0.0878 0.4008 0.5
0.0885 0.3952 0.5
0.0932 0.3859 0.5
0.0661 0.3105 1
0.0006 0.5 0.5
0.0766 0.3381 1
0.0124 0.5 0.5
0.0902 0.3872 0.5
0.0788 0.3469 0.5
0.0744 0.3371 1
0.0917 0.76 0.5
0.0006 0.5 0.5
0.0885 0.38 0.5
0.0115 0.8254 0.5
0.0614 0.4905 0.5
0.09 0.3856 0.5
0.0825 0.395 1
0.0898 0.388 0.5
0.0785 0.3546 1
0.0855 0.4048 0.5
0.0855 0.3965 0.5
0.0808 0.3589 1
0.0913 0.4084 0.5
0.0886 0.3725 1
0.0784 0.766 0.5
0.0782 0.3584 1
0.0473 0.4582 1
0.0919 0.3894 0.5
0.0906 0.4211 1
0.0937 0.3983 0.5
0.0778 0.2723 0.5
0.0854 0.368 0.5
0.0072 0.5 0.5
0.0565 0.513 0.5
0.0811 0.3835 0.5
0.0822 0.3544 0.5
0.0808 0.4976 1
0.0578 0.5 0.5
0.0947 0.3919 0.5
0.0891 0.4065 0.5
0.0832 0.3853 0.5
0.0891 0.3748 0.5
0.0836 0.4016 1
0.0867 0.3611 0.5
0.0877 0.3703 0.5
0.0931 0.4131 0.5
0.0866 0.3965 0.5
0.0746 0.2979 1
0.0785 0.7428 0.5
0.0006 0.5 0.5
0.0746 0.2979 1
0.0861 0.3665 1
0.0802 0.3726 0.5
0.0824 0.7893 0.5
0.0801 0.5193 1
0.0859 0.3676 0.5
0.0701 0.6673 1
0.0934 0.3952 1
0.0693 0.3086 1
0.0887 0.3854 0.5
0.0933 0.3971 1
0.0828 0.3611 1
0.0848 0.3654 0.5
0.0676 0.4278 1
0.0872 0.3879 0.5
0.0681 0.282 0.5
0.0856 0.3829 0.5
0.0859 0.3771 0.5
0.0904 0.388 0.5
0.0847 0.3728 1
0.0703 0.282 0.5
0.0006 0.5 0.5
0.0814 0.3388 0.5
0.0693 0.2676 0.5
0.0906 0.3653 0.5
0.0931 0.3822 0.5
0.0904 0.385 0.5
0.0905 0.392 0.5
0.0888 0.4111 1
0.0846 0.3834 0.5
0.0902 0.384 0.5
0.0901 0.3833 0.5
0.0759 0.7344 1
0.0954 0.378 0.5
0.0779 0.7604 0.5
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0019 0.3675 0.5
0.0835 0.7944 0.5
0.0012 0.5 0.5
0.0808 0.3589 1
0.0879 0.3794 1
0.0662 0.6327 0.5
0.0852 0.3669 0.5
0.0933 0.3903 0.5
0.0012 0.5 0.5
0.0902 0.3808 0.5
0.0026 0.2589 0.5
0.0104 0.4448 0.5
0.0778 0.2723 0.5
0.0863 0.3613 0.5
0.0006 0.5 0.5
0.0086 0.5 0.5
0.0904 0.3997 0.5
0.0852 0.3794 0.5
0.0955 0.3879 0.5
0.0701 0.6657 0.5
0.0838 0.798 0.5
0.0967 0.3866 0.5
0.0869 0.3613 1
0.0851 0.3655 1
0.0684 0.661 1
0.0443 0.5 0.5
0.0801 0.5193 1
0.0805 0.3768 0.5
0.0924 0.363 0.5
0.0912 0.3836 0.5
0.0856 0.3899 0.5
0.0875 0.4019 0.5
0.0808 0.7747 0.5
0.0916 0.4286 1
0.0006 0.5 0.5
0.0017 0.5 0.5
0.0779 0.2877 1
0.0906 0.4211 1
0.0602 0.2622 0.5
0.0676 0.4278 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier MUL_2955 (Mycobacterium ulcerans), fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT
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