pI: 5.1143 |
Length (AA): 441 |
MW (Da): 47895 |
Paralog Number:
8
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 441 | 5hm3 (A) | 23 | 532 | 26.00 | 0 | 1 | 1.0335 | 0.48 |
3 | 391 | 3tsy (A) | 62 | 482 | 32.00 | 0 | 1 | 1.28259 | -0.69 |
4 | 434 | 5bsr (A) | 27 | 535 | 34.00 | 0 | 1 | 1.27182 | -0.43 |
27 | 436 | 4fut (A) | 27 | 435 | 38.00 | 0 | 1 | 1.29711 | 0.14 |
344 | 384 | 3wv5 (B) | 377 | 423 | 44.00 | 0 | 0.11 | 0.224971 | 1.61 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126609)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G65060 | 4-coumarate--CoA ligase 3 |
Arabidopsis thaliana | AT3G48990 | 4-coumarate--CoA ligase-like 10 |
Arabidopsis thaliana | AT1G20510 | OPC-8:0 CoA ligase1 |
Arabidopsis thaliana | AT1G30520 | 2-succinylbenzoate--CoA ligase |
Arabidopsis thaliana | AT3G21230 | 4-coumarate--CoA ligase 5 |
Arabidopsis thaliana | AT1G20490 | 4-coumarate--CoA ligase-like 3 |
Arabidopsis thaliana | AT1G20480 | AMP-dependent synthetase and ligase family protein |
Arabidopsis thaliana | AT3G21240 | 4-coumarate--CoA ligase 2 |
Arabidopsis thaliana | AT1G51680 | 4-coumarate--CoA ligase 1 |
Arabidopsis thaliana | AT1G20500 | 4-coumarate--CoA ligase-like 4 |
Arabidopsis thaliana | AT5G38120 | 4-coumarate--CoA ligase-like 8 |
Arabidopsis thaliana | AT4G05160 | 4-coumarate--CoA ligase-like 7 |
Brugia malayi | Bm1_51305 | AMP-binding enzyme family protein |
Brugia malayi | Bm1_29700 | AMP-binding enzyme family protein |
Brugia malayi | Bm1_03830 | AMP-binding enzyme family protein |
Caenorhabditis elegans | CELE_F46E10.1 | Protein ACS-1, isoform A |
Caenorhabditis elegans | CELE_F25C8.4 | Protein ACS-12 |
Caenorhabditis elegans | CELE_F11A3.1 | Protein ACS-14 |
Caenorhabditis elegans | CELE_C01G6.7 | Protein ACS-7 |
Chlamydia trachomatis | CT_776 | acylglycerophosphoethanolamine acyltransferase |
Dictyostelium discoideum | DDB_G0284745 | 4-coumarate-CoA ligase |
Dictyostelium discoideum | DDB_G0279561 | AMP-dependent synthetase and ligase domain-containing protein |
Dictyostelium discoideum | DDB_G0284743 | 4-coumarate-CoA ligase |
Dictyostelium discoideum | DDB_G0284831 | 4-coumarate-CoA ligase |
Drosophila melanogaster | Dmel_CG9009 | pudgy |
Drosophila melanogaster | Dmel_CG12512 | CG12512 gene product from transcript CG12512-RA |
Drosophila melanogaster | Dmel_CG6178 | CG6178 gene product from transcript CG6178-RA |
Escherichia coli | b1701 | short chain acyl-CoA synthetase, anaerobic |
Escherichia coli | b1805 | acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) |
Escherichia coli | b0037 | putative crotonobetaine/carnitine-CoA ligase |
Entamoeba histolytica | EHI_010560 | acyl-CoA synthetase, putative |
Entamoeba histolytica | EHI_131880 | acyl-coA synthetase, putative |
Entamoeba histolytica | EHI_135740 | acyl-CoA synthetase, putative |
Homo sapiens | ENSG00000167107 | acyl-CoA synthetase family member 2 |
Leishmania braziliensis | LbrM.19.1280 | 4-coumarate:coa ligase-like protein |
Leishmania donovani | LdBPK_190940.1 | 4-coumarate:coa ligase-like protein |
Leishmania donovani | LdBPK_190970.1 | 4-coumarate:coa ligase-like protein |
Leishmania infantum | LinJ.19.0960 | 4-coumarate:coa ligase-like protein |
Leishmania infantum | LinJ.19.0970 | 4-coumarate:coa ligase-like protein |
Leishmania infantum | LinJ.19.0940 | 4-coumarate:coa ligase-like protein |
Leishmania infantum | LinJ.19.0950 | 4-coumarate:coa ligase-like protein |
Leishmania major | LmjF.19.1005 | 4-coumarate:coa ligase-like protein |
Leishmania major | LmjF.19.0995 | 4-coumarate:coa ligase-like protein |
Leishmania major | LmjF.19.0985 | 4-coumarate:coa ligase-like protein |
Leishmania mexicana | LmxM.19.0985 | 4-coumarate:coa ligase-like protein |
Leishmania mexicana | LmxM.19.1005 | 4-coumarate:coa ligase-like protein |
Leishmania mexicana | LmxM.19.0995 | 4-coumarate:coa ligase-like protein |
Loa Loa (eye worm) | LOAG_15996 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07755 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15223 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13706 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00184 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04571 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04570 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14723 | hypothetical protein |
Mycobacterium leprae | ML2661c | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) |
Mycobacterium leprae | ML2546c | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) |
Mus musculus | ENSMUSG00000076435 | acyl-CoA synthetase family member 2 |
Mycobacterium tuberculosis | Rv0119 | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) |
Mycobacterium tuberculosis | Rv3561 | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) |
Mycobacterium tuberculosis | Rv2505c | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) |
Mycobacterium tuberculosis | Rv0166 | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) |
Mycobacterium tuberculosis | Rv3089 | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) |
Mycobacterium tuberculosis | Rv0270 | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) |
Mycobacterium tuberculosis | Rv0404 | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) |
Mycobacterium ulcerans | MUL_3844 | fatty-acid-CoA ligase |
Mycobacterium ulcerans | MUL_1191 | acyl-CoA synthetase |
Mycobacterium ulcerans | MUL_3145 | hypothetical protein |
Mycobacterium ulcerans | MUL_3890 | long-chain fatty-acid CoA ligase |
Mycobacterium ulcerans | MUL_0362 | acyl-CoA synthetase |
Mycobacterium ulcerans | MUL_4803 | acyl-CoA synthetase |
Mycobacterium ulcerans | MUL_4126 | long-chain-fatty-acid--CoA ligase |
Mycobacterium ulcerans | MUL_1115 | long-chain-fatty-acid-CoA ligase |
Mycobacterium ulcerans | MUL_3431 | fatty-acid-CoA ligase |
Oryza sativa | 4341718 | Os06g0656500 |
Oryza sativa | 4345054 | Os08g0245200 |
Oryza sativa | 4330407 | Os02g0697400 |
Oryza sativa | 4331650 | Os03g0152400 |
Oryza sativa | 4337447 | Os04g0683700 |
Oryza sativa | 4345717 | Os08g0448000 |
Oryza sativa | 4328485 | Os02g0177600 |
Oryza sativa | 4331515 | Os03g0132000 |
Oryza sativa | 4344589 | Os08g0130400 |
Onchocerca volvulus | OVOC11935 |
|
Plasmodium berghei | PBANKA_1118700 | acyl-CoA synthetase, putative |
Plasmodium falciparum | PF3D7_0619500 | acyl-CoA synthetase |
Plasmodium knowlesi | PKNH_1130800 | acyl-CoA synthetase, putative |
Plasmodium vivax | PVX_114100 | acyl-CoA synthetase, putative |
Plasmodium yoelii | PY05696 | peroxisomal-coenzyme a synthetase |
Saccharomyces cerevisiae | YBR222C | Pcs60p |
Schmidtea mediterranea | mk4.042846.01 | |
Schmidtea mediterranea | mk4.034971.02 | |
Schmidtea mediterranea | mk4.000024.07 | |
Schmidtea mediterranea | mk4.000024.09 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3142 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu273 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu407 | Mycobacterium tuberculosis | essential | nmpdr |
b0037 | Escherichia coli | non-essential | goodall |
b1701 | Escherichia coli | non-essential | goodall |
b1805 | Escherichia coli | non-essential | goodall |
CELE_F46E10.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F46E10.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F46E10.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F46E10.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F46E10.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F46E10.1 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1118700 | Plasmodium berghei | Dispensable | plasmo |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Photinus pyralis | Luciferin 4-monooxygenase | Compounds | References |
Luciola lateralis | Luciferase | Compounds | References |
Photuris pennsylvanica | Luciferase | Compounds | References |
Photuris pennsylvanica | Luciferin 4-monooxygenase | Compounds | References |