Detailed view for MUL_3411

Basic information

TDR Targets ID: 953650
Mycobacterium ulcerans, acyl-CoA dehydrogenase FadE22
Source Database / ID:  KEGG  

pI: 5.0859 | Length (AA): 721 | MW (Da): 76758 | Paralog Number: 13

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00441   Acyl-CoA dehydrogenase, C-terminal domain
PF02770   Acyl-CoA dehydrogenase, middle domain
PF02771   Acyl-CoA dehydrogenase, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016627   oxidoreductase activity, acting on the CH-CH group of donors  
GO:0050660   FAD binding  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 114 5gj8 (D) 9 119 17.00 0 0.47 0.382853 -0.95
4 511 2uxw (A) 93 616 19.00 0 1 0.679477 0.88
4 338 1siq (A) 15 376 22.00 0 1 0.625332 -0.13
46 263 3sf6 (A) 66 310 32.00 0.000051 0.86 0.384958 0.85
253 300 4x8w (H) 1 307 35.00 0.099 0.09 0.0602742 2.93
332 713 2ix5 (A) 41 424 21.00 0 1 0.72052 -0.03
386 715 1r2j (A) 32 365 22.00 0 1 0.658398 -0.13
430 563 5ys9 (A) 126 277 22.00 0.0000059 0.81 0.331553 -0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_145209)

Species Accession Gene Product
Mycobacterium tuberculosis Rv3573c   Probable acyl-CoA dehydrogenase FadE34
Mycobacterium tuberculosis Rv1934c   Probable acyl-CoA dehydrogenase FadE17
Mycobacterium tuberculosis Rv3061c   Probable acyl-CoA dehydrogenase FadE22
Mycobacterium tuberculosis Rv3560c   Probable acyl-CoA dehydrogenase FadE30
Mycobacterium tuberculosis Rv0271c   Probable acyl-CoA dehydrogenase FadE6
Mycobacterium tuberculosis Rv3562   Probable acyl-CoA dehydrogenase FadE31
Mycobacterium ulcerans MUL_4958   acyl-CoA dehydrogenase FadE6
Mycobacterium ulcerans MUL_3411   acyl-CoA dehydrogenase FadE22
Mycobacterium ulcerans MUL_0322   acyl-CoA dehydrogenase
Mycobacterium ulcerans MUL_4144   acyl-CoA dehydrogenase FadE34
Mycobacterium ulcerans MUL_3842   acyl-CoA dehydrogenase FadE17
Mycobacterium ulcerans MUL_4125   acyl-CoA dehydrogenase FadE30
Mycobacterium ulcerans MUL_3681   acyl-CoA dehydrogenase FadE17
Mycobacterium ulcerans MUL_2757   acyl-CoA dehydrogenase
Mycobacterium ulcerans MUL_0360   acyl-CoA dehydrogenase
Mycobacterium ulcerans MUL_1194   acyl-CoA dehydrogenase FadE6
Mycobacterium ulcerans MUL_4127   acyl-CoA dehydrogenase FadE31
Mycobacterium ulcerans MUL_3874   acyl-CoA dehydrogenase
Mycobacterium ulcerans MUL_3854   acyl-CoA dehydrogenase
Mycobacterium ulcerans MUL_2892   acyl-CoA dehydrogenase FadE17

Essentiality

MUL_3411 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3114 Mycobacterium tuberculosis non-essential nmpdr
mtu3621 Mycobacterium tuberculosis non-essential nmpdr
mtu274 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_3411 (Mycobacterium ulcerans), acyl-CoA dehydrogenase FadE22
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