pI: 5.9311 |
Length (AA): 423 |
MW (Da): 44477 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 421 | 4ghk (A) | 2 | 422 | 47.00 | 0 | 1 | 1.42688 | 0.03 |
21 | 421 | 1o20 (A) | 2 | 414 | 48.00 | 0 | 1 | 1.53419 | -0.53 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127763)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G55610 | delta 1-pyrroline-5-carboxylate synthase 2 |
Arabidopsis thaliana | AT2G39800 | delta1-pyrroline-5-carboxylate synthase 1 |
Candida albicans | CaO19.6779 | gamma-glutamyl phosphate reductase |
Candida albicans | CaO19.14071 | gamma-glutamyl phosphate reductase |
Caenorhabditis elegans | CELE_T22H6.2 | Protein ALH-13, isoform B |
Cryptosporidium hominis | Chro.70551 | COG0014: gamma-glutamyl phosphate reductase |
Cryptosporidium parvum | cgd7_4940 | gpantothenate kinase 4, rnaseH fold |
Drosophila melanogaster | Dmel_CG7470 | CG7470 gene product from transcript CG7470-RB |
Escherichia coli | b0243 | gamma-glutamylphosphate reductase |
Homo sapiens | ENSG00000059573 | aldehyde dehydrogenase 18 family, member A1 |
Leishmania braziliensis | LbrM.32.3430 | pyrroline-5-carboxylate synthetase-like protein |
Leishmania donovani | LdBPK_323340.1 | pyrroline-5-carboxylate synthetase-like protein |
Leishmania infantum | LinJ.32.3340 | pyrroline-5-carboxylate synthetase-like protein |
Leishmania major | LmjF.32.3140 | pyrroline-5-carboxylate synthetase-like protein |
Leishmania mexicana | LmxM.31.3140 | pyrroline-5-carboxylate synthetase-like protein |
Mycobacterium leprae | ML1458c | PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE |
Mus musculus | ENSMUSG00000025007 | aldehyde dehydrogenase 18 family, member A1 |
Mycobacterium tuberculosis | Rv2427c | Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde |
Mycobacterium ulcerans | MUL_3696 | gamma-glutamyl phosphate reductase |
Neospora caninum | NCLIV_036210 | MGC81784 protein, related |
Oryza sativa | 4338979 | Os05g0455500 |
Oryza sativa | 4324853 | Os01g0848200 |
Saccharomyces cerevisiae | YOR323C | glutamate-5-semialdehyde dehydrogenase |
Schistosoma japonicum | Sjp_0205690 | ko:K00147 glutamate-5-semialdehyde dehydrogenase [EC1.2.1.41], putative |
Schistosoma mansoni | Smp_145020 | delta 1-pyrroline-5-carboxylate synthetase |
Schmidtea mediterranea | mk4.004716.05 | Probable delta-1-pyrroline-5-carboxylate synthase |
Schmidtea mediterranea | mk4.006666.03 | Probable delta-1-pyrroline-5-carboxylate synthase |
Schmidtea mediterranea | mk4.041120.00 | Probable delta-1-pyrroline-5-carboxylate synthase |
Schmidtea mediterranea | mk4.032424.00 | Probable delta-1-pyrroline-5-carboxylate synthase |
Trypanosoma cruzi | TcCLB.511023.10 | pyrroline-5-carboxylate synthetase-like protein, putative |
Trypanosoma cruzi | TcCLB.509067.70 | pyrroline-5-carboxylate synthetase-like protein, putative |
Toxoplasma gondii | TGME49_270550 | gamma-glutamyl phosphate reductase, putative |
Treponema pallidum | TP0350 | gamma-glutamyl phosphate reductase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2469 | Mycobacterium tuberculosis | non-essential | nmpdr |
b0243 | Escherichia coli | non-essential | goodall |
CELE_T22H6.2 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_270550 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.